Source: BEFREE

Variant Gene Disease Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs10993994
rs10993994
CUI: C0600139
Disease: Prostate carcinoma
Prostate carcinoma
0.900 GeneticVariation BEFREE MSMB gene rs10993994 polymorphism increases the risk of prostate cancer. 28212531

2018

dbSNP: rs10993994
rs10993994
CUI: C0600139
Disease: Prostate carcinoma
Prostate carcinoma
0.900 GeneticVariation BEFREE BACKGROUND.With recent advances in high-throughput sequencing technologies, many prostate cancer risk loci have been identified, including rs10993994, a single nucleotide polymorphism (SNP) located near the MSMB gene. 24464504

2014

dbSNP: rs10993994
rs10993994
CUI: C0600139
Disease: Prostate carcinoma
Prostate carcinoma
0.900 GeneticVariation BEFREE The rs10993994 genotype in the MSMB gene modifies the association between number of sexual partners and PCa risk. 24037734

2014

dbSNP: rs10993994
rs10993994
CUI: C0600139
Disease: Prostate carcinoma
Prostate carcinoma
0.900 GeneticVariation BEFREE Regardless of race and ethnicity or rs10993994 genotype, men with low blood levels of MSP have increased risk of prostate cancer. 23213189

2013

dbSNP: rs10993994
rs10993994
CUI: C0600139
Disease: Prostate carcinoma
Prostate carcinoma
0.900 GeneticVariation BEFREE Association of prostate cancer susceptibility variant (MSMB) rs10993994 with risk of spermatogenic failure. 23608167

2013

dbSNP: rs10993994
rs10993994
CUI: C0600139
Disease: Prostate carcinoma
Prostate carcinoma
0.900 GeneticVariation BEFREE These data indicate that the increase in PC risk associated with rs10993994:C>T is likely mediated by the variant's effect on PSP94 expression; however, this effect does not extend to NCOA4 in the data presented here. 22887727

2013

dbSNP: rs10993994
rs10993994
CUI: C0600139
Disease: Prostate carcinoma
Prostate carcinoma
0.900 GeneticVariation BEFREE After allowing for multiple testing, none of the SNPs examined were significantly associated with growth factor or hormone concentrations, and the SNP-prostate cancer associations did not differ by these concentrations, although 4 interactions were marginally significant (MSMB-rs10993994 with androstenedione (uncorrected P = 0.008); CTBP2-rs4962416 with IGFBP-3 (uncorrected P = 0.003); 11q13.2-rs12418451 with IGF-1 (uncorrected P = 0.006); and 11q13.2-rs10896449 with SHBG (uncorrected P = 0.005)). 22459122

2012

dbSNP: rs10993994
rs10993994
CUI: C0600139
Disease: Prostate carcinoma
Prostate carcinoma
0.900 GeneticVariation BEFREE Six markers associated with early-onset prostate cancer [rs2171492 (7q32), rs6983561 (8q24), rs10993994 (10q11), rs4430796 (17q12), rs1799950 (17q21), and rs266849 (19q13)] were genotyped. 22144497

2012

dbSNP: rs10993994
rs10993994
CUI: C0600139
Disease: Prostate carcinoma
Prostate carcinoma
0.900 GeneticVariation BEFREE Of note, rs7000448 is in strong linkage disequilibrium with rs10761581 in NCOA4, a SNP that has been implicated to be independently associated, with respect to the widely reported SNP rs10993994 in the nearby gene MSMB, with prostate cancer in men of European descent. 20717903

2011

dbSNP: rs10993994
rs10993994
CUI: C0600139
Disease: Prostate carcinoma
Prostate carcinoma
0.900 GeneticVariation BEFREE Genome-wide association studies (GWAS) have established a variant, rs10993994, on chromosome 10q11 as being associated with prostate cancer risk. 21085629

2011

dbSNP: rs10993994
rs10993994
CUI: C0600139
Disease: Prostate carcinoma
Prostate carcinoma
0.900 GeneticVariation BEFREE We examined the association between rs10993994 genotype and MSP levels in a sample of 500 prostate cancer-free men from four racial/ethnic populations in the Multiethnic Cohort (European Americans, African Americans, Latinos, and Japanese Americans). 20736317

2011

dbSNP: rs10993994
rs10993994
CUI: C0600139
Disease: Prostate carcinoma
Prostate carcinoma
0.900 GeneticVariation BEFREE Recent functional work has shown that different alleles of the significantly associated SNP in the promoter of MSMB found to be associated with prostate cancer risk, rs10993994, can influence its expression in tumors and in vitro studies. 19644707

2011

dbSNP: rs10993994
rs10993994
CUI: C0600139
Disease: Prostate carcinoma
Prostate carcinoma
0.900 GeneticVariation BEFREE The rs10993994 risk allele for prostate cancer results in clinically relevant changes in microseminoprotein-beta expression in tissue and urine. 20967219

2011

dbSNP: rs10993994
rs10993994
CUI: C0600139
Disease: Prostate carcinoma
Prostate carcinoma
0.900 GeneticVariation BEFREE Our results suggest a mechanism by which rs10993994 might predispose to prostate cancer and raise the possibility that genetic variation might need to be considered in interpreting the levels of these biomarkers. 20696662

2010

dbSNP: rs10993994
rs10993994
CUI: C0600139
Disease: Prostate carcinoma
Prostate carcinoma
0.900 GeneticVariation BEFREE SNP rs10993994 is 2 bp upstream of the transcription initiation site of MSMB and was identified as an associated PrCa risk variant. 19997100

2010

dbSNP: rs10993994
rs10993994
CUI: C0600139
Disease: Prostate carcinoma
Prostate carcinoma
0.900 GeneticVariation BEFREE In conclusion, loci associated with risk for prostate cancer, such as rs7920517 and rs10993994, might also be used to predict the recurrence of prostate-specific antigen in prostate cancer patients receiving radical prostatectomy. 19900942

2010

dbSNP: rs10993994
rs10993994
CUI: C0600139
Disease: Prostate carcinoma
Prostate carcinoma
0.900 GeneticVariation BEFREE rs10993994 in MSMB promoter affects serum MSMB expression, contributes to the genetic predisposition to prostate cancer in southern Chinese Han population. 20333697

2010

dbSNP: rs10993994
rs10993994
CUI: C0600139
Disease: Prostate carcinoma
Prostate carcinoma
0.900 GeneticVariation BEFREE The observations that rs10993994 is the strongest associated variant in the region and its risk allele has a major effect on the transcriptional activity of MSMB, a gene with previously described prostate cancer suppressor function, together suggest the T allele of rs10993994 as a potential causal variant at 10q11 that confers increased risk of prostate cancer. 19153072

2009

dbSNP: rs10993994
rs10993994
CUI: C0600139
Disease: Prostate carcinoma
Prostate carcinoma
0.900 GeneticVariation BEFREE Further investigation is warranted to determine whether rs10993994 alone or in combination with additional variants contributes to prostate cancer susceptibility. 19383797

2009

dbSNP: rs10993994
rs10993994
CUI: C0600139
Disease: Prostate carcinoma
Prostate carcinoma
0.900 GeneticVariation BEFREE For the two SNPs that had significant differences between more and less aggressive disease rs2735839 in KLK3 (P = 8.4 x 10(-7)) and rs10993994 in MSMB (P = 0.046), the alleles that are associated with increased risk for PCa were more frequent in patients with less aggressive disease. 19434657

2009

dbSNP: rs2735839
rs2735839
CUI: C0600139
Disease: Prostate carcinoma
Prostate carcinoma
0.890 GeneticVariation BEFREE Our results provide further support that a PC-risk SNP rs2735839 near the KLK3 gene on chromosome 19q13 may be associated with aggressive and high-grade PC. 25715684

2015

dbSNP: rs2735839
rs2735839
CUI: C0600139
Disease: Prostate carcinoma
Prostate carcinoma
0.890 GeneticVariation BEFREE The prostate cancer susceptibility variant rs2735839 near KLK3 gene is associated with aggressive prostate cancer and can stratify gleason score 7 patients. 25274378

2015

dbSNP: rs2735839
rs2735839
CUI: C0600139
Disease: Prostate carcinoma
Prostate carcinoma
0.890 GeneticVariation BEFREE When comparing prostate cancer cases with low PSA controls, alleles at genetic markers rs1512268, rs445114, rs10788160, rs11199874, rs17632542, rs266849, and rs2735839 were associated with an increased risk of prostate cancer, but the effect-estimates were attenuated to the null when using high PSA controls (Pheterogeneity in effect-estimates < 0.04). 24753544

2015

dbSNP: rs2735839
rs2735839
CUI: C0600139
Disease: Prostate carcinoma
Prostate carcinoma
0.890 GeneticVariation BEFREE Four GWAS replication SNPs (rs2660753, rs13254738, rs10090154, rs2735839) and seven flanking SNPs were associated with CaP aggressiveness (P < 0.05) in three genomic regions: One at 3p12 (EA), seven at 8q24 (5 AA, 2 EA), and three at 19q13 at the kallilkrein-related peptidase 3 (KLK3) locus (two AA, one AA and EA). 22549899

2013

dbSNP: rs2735839
rs2735839
CUI: C0600139
Disease: Prostate carcinoma
Prostate carcinoma
0.890 GeneticVariation BEFREE We did not observe a strong association with the KLK3 variant, reported in previous studies to confer risk for prostate cancer (rs2735839; P = 0.20) but did observe three highly correlated SNPs (rs17632542, rs62113212 and rs62113214) associated with prostate cancer [P = 3.41 × 10(-4), per-allele trend odds ratio (OR) = 0.77, 95% CI = 0.67-0.89]. 21318478

2011