|
rs1800795
|
|
Acute GVH disease
|
|
0.020 |
GeneticVariation
|
BEFREE |
Furthermore, the IL-6R rs4845618 donor genotype showed an association with severe acute graft-versus-host disease (GVHD), whereas the donor genotype of the IL-6 SNP rs1800795 was associated with decreased survival 100 days post-transplant.
|
29513361 |
2018 |
|
rs1800795
|
|
Acute GVH disease
|
|
0.020 |
GeneticVariation
|
BEFREE |
Similar to previous publications, the IL6 donor genotype for rs1800795 was associated with a 20%-50% increased risk for grade IIb-IV aGVHD after unrelated HCT in the allelic (adjusted P = .011) and recessive (adjusted P = .0013) models.
|
22282500 |
2012 |
|
rs2910164
|
|
Acute GVH disease
|
|
0.020 |
GeneticVariation
|
BEFREE |
We aim to analyze the association between NF-κB1 encoding p50 (rs28362491, -94 in.ertion/deletion ATTG) and miR-146a (rs2910164, G > C) polymorphisms and risk of aGVHD.
|
31813598 |
2019 |
|
rs2910164
|
|
Acute GVH disease
|
|
0.020 |
GeneticVariation
|
BEFREE |
In humans, the minor genotype of the single nucleotide polymorphism rs2910164 in HCT donors, which reduces expression of miR-146a, was associated with severe acute GVHD (grade III/IV).
|
25205119 |
2014 |
|
rs4693608
|
|
Acute GVH disease
|
|
0.020 |
GeneticVariation
|
BEFREE |
Similarly, the discrepancy in rs4693608 HPSE SNP between recipients and donors was found to be a more significant factor for the risk of aGVHD than patient genotype.
|
24319286 |
2014 |
|
rs4693608
|
|
Acute GVH disease
|
|
0.020 |
GeneticVariation
|
BEFREE |
The present study indicates a highly significant correlation of HPSE gene SNPs rs4693608 and rs4364254 and their combination with the risk of developing acute GVHD.
|
20075159 |
2010 |
|
rs10737416
|
|
Acute GVH disease
|
|
0.010 |
GeneticVariation
|
BEFREE |
The results showed that the genetic markers rs4833079 (P = 0.035) in TLR1, rs4837656 (P = 0.032) and rs17582214 (P = 0.029) in TLR4, rs10737416 (P = 0.048) in TLR5, rs6531656 (P = 0.035) in TLR6, and rs337629 (P = 0.005) in TLR10 were associated with the occurrence of acute GvHD.
|
22703024 |
2012 |
|
rs11209026
|
|
Acute GVH disease
|
|
0.010 |
GeneticVariation
|
BEFREE |
Among recipients of hematopoietic cells from HLA-identical donors, the IL-23R (A</span>rg381Gln) gene variant on the donor side has a protective effect on the occurrence of acute GVHD in recipients after transplantation.
|
18209723 |
2008 |
|
rs1129055
|
|
Acute GVH disease
|
|
0.010 |
GeneticVariation
|
BEFREE |
Moreover, analysis of gene-gene interaction between <i>CD86</i> and <i>CTLA-4</i> showed that having both the A allele for <i>CD86</i> rs1129055 and the <i>CTLA-4</i> CT60GG genotype in recipients increased the risk of aGvHD about 3.5 times.
|
29577049 |
2018 |
|
rs1217691063
|
|
Acute GVH disease
|
|
0.010 |
GeneticVariation
|
BEFREE |
Recipient MTHFR polymorphisms (C677T) were associated with acute GvHD (P=0.03), and recipient VDR TaqI with TRM and overall survival (P=0.006 and P=0.04, respectively).Genetic factors that interfere with drug metabolisms are associated with treatment-related toxicities, GvHD and survival after HLA-identical HSCT in patients with leukemia and should be investigated prospectively.
|
19005482 |
2009 |
|
rs1238539471
|
|
Acute GVH disease
|
|
0.010 |
GeneticVariation
|
BEFREE |
Genetic variations of interleukin-23R (1143A>G) and BPI (A645G), but not of NOD2, are associated with acute graft-versus-host disease after allogeneic transplantation.
|
20541026 |
2010 |
|
rs1367967034
|
|
Acute GVH disease
|
|
0.010 |
GeneticVariation
|
BEFREE |
Genetic variations of interleukin-23R (1143A>G) and BPI (A645G), but not of NOD2, are associated with acute graft-versus-host disease after allogeneic transplantation.
|
20541026 |
2010 |
|
rs16910526
|
|
Acute GVH disease
|
|
0.010 |
GeneticVariation
|
BEFREE |
The fact that this was not the case in patients from pairs with the Y238X polymorphism (OR=1.2, ns) suggests that despite increased colonization defective dectin-1 signaling might have prevented an impact of Candida colonization on the incidence of acute GvHD to occur.
|
20452827 |
2010 |
|
rs17114808
|
|
Acute GVH disease
|
|
0.010 |
GeneticVariation
|
BEFREE |
The incidence of acute GVHD among patients homozygous for CC at SUFU rs17114808 was 69%, which was significantly higher than the 8% rate observed in CT heterozygous patients (p = 0.0002).
|
26067905 |
2015 |
|
rs17582214
|
|
Acute GVH disease
|
|
0.010 |
GeneticVariation
|
BEFREE |
The results showed that the genetic markers rs4833079 (P = 0.035) in TLR1, rs4837656 (P = 0.032) and rs17582214 (P = 0.029) in TLR4, rs10737416 (P = 0.048) in TLR5, rs6531656 (P = 0.035) in TLR6, and rs337629 (P = 0.005) in TLR10 were associated with the occurrence of acute GvHD.
|
22703024 |
2012 |
|
rs1800797
|
|
Acute GVH disease
|
|
0.010 |
GeneticVariation
|
BEFREE |
Our study suggested that this risk model could identify patients at high risk of SR aGVHD with donor genotype of IL6 (rs1800797) and IFNG (rs2069727) along with gastrointestinal involvement of aGVHD.
|
25774595 |
2015 |
|
rs2069727
|
|
Acute GVH disease
|
|
0.010 |
GeneticVariation
|
BEFREE |
Our study suggested that this risk model could identify patients at high risk of SR aGVHD with donor genotype of IL6 (rs1800797) and IFNG (rs2069727) along with gastrointestinal involvement of aGVHD.
|
25774595 |
2015 |
|
rs2232365
|
|
Acute GVH disease
|
|
0.010 |
GeneticVariation
|
BEFREE |
rs3761549, rs5902434, and rs2232365 are associated with an increased risk of acute GVHD and decreased risk of post-HSCT infection.
|
30027704 |
2018 |
|
rs2275913
|
|
Acute GVH disease
|
|
0.010 |
GeneticVariation
|
BEFREE |
These findings substantiate the functional relevance of the rs2275913 polymorphism and indicate that the higher IL-17 secretion by individuals with the 197A allele likely accounts for their increased risk for acute GVHD and certain autoimmune diseases.
|
22028838 |
2011 |
|
rs2278293
|
|
Acute GVH disease
|
|
0.010 |
GeneticVariation
|
BEFREE |
Recipient and donor IMPDH genotypes (rs11706052, rs2278294, rs2278293) were not associated with day 28 T cell chimerism, acute graft-versus-host disease (GVHD), disease relapse, cytomegalovirus reactivation, nonrelapse mortality, or overall survival.
|
29656138 |
2018 |
|
rs2278294
|
|
Acute GVH disease
|
|
0.010 |
GeneticVariation
|
BEFREE |
Recipient and donor IMPDH genotypes (rs11706052, rs2278294, rs2278293) were not associated with day 28 T cell chimerism, acute graft-versus-host disease (GVHD), disease relapse, cytomegalovirus reactivation, nonrelapse mortality, or overall survival.
|
29656138 |
2018 |
|
rs2302217
|
|
Acute GVH disease
|
|
0.010 |
GeneticVariation
|
BEFREE |
Furthermore, multivariate analysis revealed the MADCAM1 rs2302217 AA genotype in recipient being also an independent factor associated with development of acute GVHD (p = 0.036) and decreased overall survival (p = 0.001).
|
19286444 |
2009 |
|
rs2310241
|
|
Acute GVH disease
|
|
0.010 |
GeneticVariation
|
BEFREE |
Donor risk alleles in rs22441131 (<i>P</i><sub>meta</sub> = .00026) and rs2310241 (<i>P</i><sub>meta</sub> = .00033) increased the cumulative incidence of aGVHD death up to fourfold and were associated with high sST2 levels.
|
31455667 |
2019 |
|
rs28362491
|
|
Acute GVH disease
|
|
0.010 |
GeneticVariation
|
BEFREE |
We aim to analyze the association between NF-κB1 encoding p50 (rs28362491, -94 in.ertion/deletion ATTG) and miR-146a (rs2910164, G > C) polymorphisms and risk of aGVHD.
|
31813598 |
2019 |
|
rs3004070
|
|
Acute GVH disease
|
|
0.010 |
GeneticVariation
|
BEFREE |
Six SNPs (rs2504787, rs2504086, rs2504082, rs3004067, rs882559, and rs3004070) of DAAM2 were associated with acute GvHD prevalence, and the genotyping was extended to larger population (N = 228).
|
21909696 |
2012 |