|
rs25487
|
|
Head and Neck Carcinoma
|
|
0.070 |
GeneticVariation
|
BEFREE |
Furthermore, the risk of HNC was associated with XRCC1 Arg399Gln polymorphism stratified by occupational exposure status (OR = 2.29; P = 0.024).
|
24020925 |
2014 |
|
rs25487
|
|
Head and Neck Carcinoma
|
|
0.070 |
GeneticVariation
|
BEFREE |
The meta-analysis results suggest that the XRCC1 Arg399Gln and Arg280His polymorphisms are probably not associated with the risk of HNC, but the XRCC1 Arg194Trp polymorphism was associated with increased risk of HNC in the subgroup analysis of studies adjusted for smoking and alcohol and with increased risk of oral cancer in the stratified analyses based on cancer site.
|
24497981 |
2014 |
|
rs25487
|
|
Head and Neck Carcinoma
|
|
0.070 |
GeneticVariation
|
BEFREE |
Our meta-analysis suggested that the XRCC1 Arg399Gln polymorphism was not a risk factor for HNC susceptibility.
|
24694255 |
2014 |
|
rs25487
|
|
Head and Neck Carcinoma
|
|
0.070 |
GeneticVariation
|
BEFREE |
In conclusion, this meta-analysis suggests that the XRCC1 Arg194Trp, Arg280His and Arg399Gln polymorphism may not involve in HNC susceptibility.
|
24086310 |
2013 |
|
rs25487
|
|
Head and Neck Carcinoma
|
|
0.070 |
GeneticVariation
|
BEFREE |
Because of the important role of the XRCC1 gene in DNA repair, we wanted to test the effects of the Arg194Trp and Arg399Gln polymorphisms of XRCC1 on the clinical outcome of head and neck cancer.
|
19846968 |
2009 |
|
rs25487
|
|
Head and Neck Carcinoma
|
|
0.070 |
GeneticVariation
|
BEFREE |
In this study, two polymorphisms of the XRCC1 gene, Arg194Trp and Arg399Gln were investigated in 95 patients with head and neck carcinoma.
|
15800678 |
2005 |
|
rs25487
|
|
Head and Neck Carcinoma
|
|
0.070 |
GeneticVariation
|
BEFREE |
Pooling data and DNA specimens from three case-control studies in western Washington State, North Carolina, and Puerto Rico, totaling 555 cases (430 whites) and 792 controls (695 whites), we studied the risk of head and neck cancer in relation to common nonsynonymous single-nucleotide polymorphisms in four DNA repair genes: MGMT (Leu84Phe and Ile143Val), XRCC1 (Arg399Gln), XPD (Lys751Gln), and XRCC3 (Thr241Met).
|
16030112 |
2005 |
|
rs1217691063
|
|
Head and Neck Carcinoma
|
|
0.050 |
GeneticVariation
|
BEFREE |
This meta-analysis demonstrates that MTHFR C677T polymorphism may not be a risk factor for the developing of HNC.
|
25802478 |
2015 |
|
rs1217691063
|
|
Head and Neck Carcinoma
|
|
0.050 |
GeneticVariation
|
BEFREE |
In conclusion, the results of the present study suggest that Homozygous TT alleles of MTHFR C677T polymorphism might be a risk factor for HNC among individuals who have a heavy drinking history.
|
26035704 |
2015 |
|
rs1217691063
|
|
Head and Neck Carcinoma
|
|
0.050 |
GeneticVariation
|
BEFREE |
There was no association between MTHFR C677T polymorphism and head and neck cancer (p = 0.50).
|
21180947 |
2011 |
|
rs1217691063
|
|
Head and Neck Carcinoma
|
|
0.050 |
GeneticVariation
|
BEFREE |
Authors report the results of four meta-analyses of studies that examined the association between methylenetetrahydrofolate reductase (MTHFR) C677T and A1298C polymorphisms and head and neck cancer (nine studies, 2076 cases and 4834 controls for C677T; four studies, 1439 cases and 3941 controls for A1298C), and lung cancer (ten studies, 5274 cases and 7435 controls for C677T; seven studies, 5098 cases and 6243 controls for A1298C).
|
18789576 |
2009 |
|
rs1217691063
|
|
Head and Neck Carcinoma
|
|
0.050 |
GeneticVariation
|
BEFREE |
Our data indicate that the C677T MTHFR polymorphism does not significantly contribute to the inherited genetic susceptibility to breast and prostate cancer, while we show some evidence for possible genetic contribution of this polymorphism to the development of head and neck carcinoma.
|
17573062 |
2007 |
|
rs2910164
|
|
Head and Neck Carcinoma
|
|
0.050 |
GeneticVariation
|
BEFREE |
Variant alleles of miR-146a rs2910164 may have a correlation with increased HNC</span> risk.
|
27901485 |
2017 |
|
rs2910164
|
|
Head and Neck Carcinoma
|
|
0.050 |
GeneticVariation
|
BEFREE |
A closer association has been found between the microRNA-146a rs2910164 polymorphism and the risk of head and neck carcinoma in some molecular epidemiological studies.
|
29049342 |
2017 |
|
rs2910164
|
|
Head and Neck Carcinoma
|
|
0.050 |
GeneticVariation
|
BEFREE |
miRNA146a rs2910164 C>G polymorphism is not associated with head and neck cancer risk in general, but tehre may be link in Chinese.
|
25987052 |
2015 |
|
rs2910164
|
|
Head and Neck Carcinoma
|
|
0.050 |
GeneticVariation
|
BEFREE |
Significantly increased risk between microRNA-146a rs2910164 G > C polymorphism and HNC risk were observed in Caucasian population (GC vs. GG: OR = 1.31, 95%CI = 1.01-1.68; GC + CC vs. GG: OR = 1.26, 95%CI = 1.02-1.57).
|
26277865 |
2015 |
|
rs2910164
|
|
Head and Neck Carcinoma
|
|
0.050 |
GeneticVariation
|
BEFREE |
Association of pre-miR-146a rs2910164 polymorphism with the risk of head and neck cancer.
|
23267167 |
2013 |
|
rs1229984
|
|
Head and Neck Carcinoma
|
|
0.040 |
GeneticVariation
|
BEFREE |
Alcohol dehydrogenase-1B Arg47His polymorphism is associated with head and neck cancer risk in Asian: a meta-analysis.
|
25323582 |
2015 |
|
rs1229984
|
|
Head and Neck Carcinoma
|
|
0.040 |
GeneticVariation
|
BEFREE |
These findings suggest that rs1229984 at 4q23 and rs671 at 12q24 may serve as candidate markers for susceptibility to HNC in Chinese population.
|
22674868 |
2013 |
|
rs1229984
|
|
Head and Neck Carcinoma
|
|
0.040 |
GeneticVariation
|
BEFREE |
An increased risk for HNC was also associated reported for P53 codon 72 Pro/Pro, ALDH2 and three variants of the ADH gene: ADH1B (rs1229984), ADH7 (rs1573496) and ADH1C (rs698).
|
22500060 |
2012 |
|
rs1229984
|
|
Head and Neck Carcinoma
|
|
0.040 |
GeneticVariation
|
BEFREE |
Multiple regression analyses showed that individuals with the mutant genotype ADH1B Arg(48)His who consume alcohol >30 g/L/day have more than four times the risk for HNC (OR = 4.42; 95% CI, 1.21-16.11).
|
19887496 |
2010 |
|
rs13181
|
|
Head and Neck Carcinoma
|
|
0.040 |
GeneticVariation
|
BEFREE |
However, no statistically significant association was observed between the risk of developing HNC and the ERCC2 Lys751Gln and ERCC3 A>G polymorphisms.
|
24020925 |
2014 |
|
rs13181
|
|
Head and Neck Carcinoma
|
|
0.040 |
GeneticVariation
|
BEFREE |
There is overall lack of association between XPD Lys751Gln polymorphism and HNC risk under all five genetic models and still no significant association was found in the subgroup analysis by ethnicity and source of controls.
|
24443924 |
2014 |
|
rs13181
|
|
Head and Neck Carcinoma
|
|
0.040 |
GeneticVariation
|
BEFREE |
In the present study we investigated the association between three polymorphisms of the MUTYH (Tyr165Cys, rs34612342), the OGG1 (Ser326Cys, rs1052133) and the XPD (Lys751Gln, rs13181) genes with head and neck cancer risk.
|
20571908 |
2011 |
|
rs13181
|
|
Head and Neck Carcinoma
|
|
0.040 |
GeneticVariation
|
BEFREE |
In conclusion, our meta-analysis demonstrated that XPD Lys751Gln polymorphism could be a prediction marker for risk of head and neck cancer.
|
22179996 |
2011 |