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rs11001553
|
|
Hypodontia
|
|
0.020 |
GeneticVariation
|
BEFREE |
In a previous study, we found that polymorphism in rs11001553 of DKK1 was associated with hypodontia in the Chinese Han population.
|
24737523 |
2014 |
|
rs11001553
|
|
Hypodontia
|
|
0.020 |
GeneticVariation
|
BEFREE |
A significant difference was observed, between subjects with non-syndromic hypodontia and controls, in the allele and genotype frequencies of two markers [rs929387 of GLI family zinc finger 3 (GLI3) and rs11001553 of Dickkopf-related protein 1 (DKK1)].
|
22984994 |
2012 |
|
rs10824310
|
|
Alzheimer Disease, Late Onset
|
|
0.010 |
GeneticVariation
|
BEFREE |
In the application to the real datasets, DCL identified rs6784615, located on the NISCH gene, and rs10824310, located on the PRKG1 gene, as direct causes of late onset Alzheimer's disease (LOAD) development.
|
28363452 |
2017 |
|
rs11001553
|
|
Agenesis
|
|
0.010 |
GeneticVariation
|
BEFREE |
These data demonstrated an association between rs11001553 of DKK1, a tooth development-associated gene, and non-syndromic tooth agenesis in Chinese Han individuals.
|
24737523 |
2014 |
|
rs145640971
|
|
Fibromatosis, Aggressive
|
|
0.010 |
GeneticVariation
|
BEFREE |
No statistically significant difference in relative expression levels of Wnt target genes AXIN2, DKK1 and CCND1 was identified between either CTNNB1 wild-type, S45F or T41A mutated DTF samples.
|
30528042 |
2019 |
|
rs149268042
|
|
Osteitis Deformans
|
|
0.010 |
GeneticVariation
|
BEFREE |
Three rare variants were identified in this study, all located in the DKK1 gene: one variant in the second exon leading to alteration in a highly conserved amino acid (p.R120L), one in the 5'-untranslated region (-50 C/A), and one in a splice site of intron 1 (IVS1 184 T/C), although none of these rare variants were associated with PDB.
|
23836157 |
2013 |
|
rs1896368
|
|
Ankylosing spondylitis
|
|
0.010 |
GeneticVariation
|
BEFREE |
Significant additive interactions were observed between DKK1: rs1896368 and LRP5: rs3736228, relative excess risk due to interaction (RERI) = 0.40, 95% CI = 0.08 - 0.71; attributable proportion due to interaction (AP) = 51%, 95% CI = 0.07 - 0.94, DKK1: rs1569198 and LRP5: rs3736228 (RERI = 0.49, 95% CI = 0.12 - 0.86; AP = 49%, 95% CI = 0.17 - 0.82), LRP5: rs3736228 and SOST: rs4792909 (RERI = 0.33, 95% CI = 0.002 - 0.65; AP = 41%, 95% CI = 0.01 - 0.81) in the dominant model.<b>Conclusions:</b> Our research implies a potential gene-gene interaction, thus revealing the importance of the Wnt/β-catenin signalling pathway for understanding the genetic architecture of AS.
|
31656088 |
2020 |