|
rs2900180
|
|
Rheumatoid Arthritis
|
A |
0.830 |
GeneticVariation
|
GWASCAT |
Studying the effects of haplotype partitioning methods on the RA-associated genomic results from the North American Rheumatoid Arthritis Consortium (NARAC) dataset.
|
30891314 |
2019 |
|
rs2900180
|
|
Rheumatoid Arthritis
|
|
0.830 |
GeneticVariation
|
BEFREE |
This meta-analysis confirms that the TRAF1-C5 rs10818488, rs3761847, rs2900180 and rs10760130 polymorphisms are associated with RA susceptibility in Europeans.
|
24144456 |
2014 |
|
rs2900180
|
|
Rheumatoid Arthritis
|
|
0.830 |
GeneticVariation
|
BEFREE |
This represents the second independent study correlating rs2900180 at the TRAF1 locus with radiological severity in RA.
|
23242182 |
2013 |
|
rs2900180
|
|
Rheumatoid Arthritis
|
|
0.830 |
GeneticVariation
|
BEFREE |
The aim of this study was to determine the influence of STAT4 (rs7574865) and TRAF1/C5 (rs10818488 and rs2900180) gene polymorphisms on the risk of developing rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE) in a Colombian population.
|
18432273 |
2008 |
|
rs2900180
|
|
Rheumatoid Arthritis
|
|
0.830 |
GeneticVariation
|
GWASDB |
TRAF1-C5 as a risk locus for rheumatoid arthritis--a genomewide study.
|
17804836 |
2007 |
|
rs387906554
|
|
Complement component 5 deficiency
|
C |
0.700 |
CausalMutation
|
CLINVAR |
|
|
|
|
rs10818488
|
|
Rheumatoid Arthritis
|
|
0.090 |
GeneticVariation
|
BEFREE |
Lack of association between single nucleotide polymorphism rs10818488 in TRAF1/C5 region and rheumatoid arthritis in iranian population.
|
24338224 |
2014 |
|
rs10818488
|
|
Rheumatoid Arthritis
|
|
0.090 |
GeneticVariation
|
BEFREE |
This meta-analysis confirms that the TRAF1-C5 rs10818488, rs3761847, rs2900180 and rs10760130 polymorphisms are associated with RA susceptibility in Europeans.
|
24144456 |
2014 |
|
rs10818488
|
|
Rheumatoid Arthritis
|
|
0.090 |
GeneticVariation
|
BEFREE |
Meta-analysis showed a weak association between TRAF1/C5 r</span>s10818488 polymorphism and RA in all subjects (OR = 1.13, 95 % CI = 1.01–1.27, P heterogeneity < 0.001).
|
24234752 |
2014 |
|
rs10818488
|
|
Rheumatoid Arthritis
|
|
0.090 |
GeneticVariation
|
BEFREE |
Taken together, our study demonstrates that the TRAF1/C5 polymorphism (rs10818488) may confer susceptibility to RA in North Africa population, and in European population, it might be a contributory factor towards SLE.
|
23321589 |
2013 |
|
rs10818488
|
|
Rheumatoid Arthritis
|
|
0.090 |
GeneticVariation
|
BEFREE |
Interestingly, alleles rs3761847 A and rs10818488 G had increased the risk for RA in the present study, while they decreased the risk in the original studies.
|
19336421 |
2010 |
|
rs10818488
|
|
Rheumatoid Arthritis
|
|
0.090 |
GeneticVariation
|
BEFREE |
We genotyped the two most significant single nucleotide polymorphisms (SNPs) (rs10818488, rs2416808) from a former RA candidate gene study.
|
20030635 |
2010 |
|
rs10818488
|
|
Rheumatoid Arthritis
|
|
0.090 |
GeneticVariation
|
BEFREE |
No statistically significant association of TRAF1/C5 SNPs rs3761847 and rs10818488 with RA was detected.
|
19445664 |
2009 |
|
rs10818488
|
|
Rheumatoid Arthritis
|
|
0.090 |
GeneticVariation
|
BEFREE |
The aim of this study was to determine the influence of STAT4 (rs7574865) and TRAF1/C5 (rs10818488 and rs2900180) gene polymorphisms on the risk of developing rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE) in a Colombian population.
|
18432273 |
2008 |
|
rs10818488
|
|
Rheumatoid Arthritis
|
|
0.090 |
GeneticVariation
|
BEFREE |
We found that mutated allele A or genotypes A/A and G/A of the TRAF1/C5 rs10818488 SNP were more common in individuals with RA than in control individuals (odds ratio [OR]=1.7, 95% confidence interval [CI]=1.35-2.15, and OR=2.22, 95% CI=1.61-3.05, respectively).
|
18625278 |
2008 |
|
rs10818488
|
|
Lupus Erythematosus, Systemic
|
|
0.050 |
GeneticVariation
|
BEFREE |
Association study of TRAF1/C5 polymorphism (rs10818488) with susceptibility to rheumatoid arthritis and systemic lupus erythematosus: a meta-analysis.
|
23321589 |
2013 |
|
rs10818488
|
|
Lupus Erythematosus, Systemic
|
|
0.050 |
GeneticVariation
|
BEFREE |
An association was found between the rs10818488 polymorphism of TRAF1-C5 and susceptibility to SLE in Europeans.
|
22820624 |
2012 |
|
rs10818488
|
|
Lupus Erythematosus, Systemic
|
|
0.050 |
GeneticVariation
|
BEFREE |
We investigated whether a single nucleotide polymorphism (SNP) of the STAT4 (rs7574865), PTPN22 (rs2476601), TRAF1/C5 (rs10818488), and C1q (rs292001) genes as well as the 27-bp VNTR polymorphism on intron 4 of eNOS, previously associated with SLE in other populations, are also associated with SLE risk in Turkey.
|
21968398 |
2011 |
|
rs10818488
|
|
Lupus Erythematosus, Systemic
|
|
0.050 |
GeneticVariation
|
BEFREE |
A significant association was detected between the rs10818488 A allele and T1D (OR 1.14, p=0.027) and SLE (OR 1.16, p=0.016), which was replicated in 99 patients with T1D, 272 with SLE and 482 controls from Crete (OR 1.64, p=0.002; OR 1.43, p=0.002, respectively).
|
19433411 |
2010 |
|
rs10818488
|
|
Lupus Erythematosus, Systemic
|
|
0.050 |
GeneticVariation
|
BEFREE |
The aim of this study was to determine the influence of STAT4 (rs7574865) and TRAF1/C5 (rs10818488 and rs2900180) gene polymorphisms on the risk of developing rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE) in a Colombian population.
|
18432273 |
2008 |
|
rs2416808
|
|
Rheumatoid Arthritis
|
|
0.020 |
GeneticVariation
|
BEFREE |
Similar findings were observed for rs2416808 susceptible genotype GG in the non-RA cohort (HR 0.99; 95%CI 0.79 to 1.25 and HR 0.89; 95%CI 0.64 to 1.25, respectively).
|
20205706 |
2010 |
|
rs2416808
|
|
Rheumatoid Arthritis
|
|
0.020 |
GeneticVariation
|
BEFREE |
We genotyped the two most significant single nucleotide polymorphisms (SNPs) (rs10818488, rs2416808) from a former RA candidate gene study.
|
20030635 |
2010 |
|
rs10818488
|
|
Neurocysticercosis
|
|
0.010 |
GeneticVariation
|
BEFREE |
This work aimed to study the possible relevance for human neurocysticercosis of single nucleotide polymorphisms (SNPs) in the C5-<i>TRAF1</i> region (rs17611 <i>C/T</i>, rs992670 <i>G/A</i>, rs25681 <i>G/A</i>, rs10818488 <i>A/G</i>, and rs3761847 <i>G/A</i>) in a Mexican population and associated with clinical and radiological traits related to neurocysticercosis severity (cell count in the cerebrospinal fluid [CSF cellularity], parasite location and parasite load in the brain, parasite degenerating stage, and epilepsy).
|
31570557 |
2019 |
|
rs10818488
|
|
Epilepsy
|
|
0.010 |
GeneticVariation
|
BEFREE |
The rs3761847 SNP was associated with epilepsy under a dominant model, whereas rs10818488 was associated with CSF cellularity and parasite load under dominant and recessive models, respectively.
|
31570557 |
2019 |
|
rs10818488
|
|
Graves Disease
|
|
0.010 |
GeneticVariation
|
BEFREE |
Allele analysis found that T allele of rs4836834, G allele of rs10760130, A allele of rs10818488, T allele of rs2239658 and T allele of rs2900180 were significantly higher in GD and AITD patients.
|
26699338 |
2016 |