|
rs4444903
|
|
Liver carcinoma
|
|
0.060 |
GeneticVariation
|
BEFREE |
Single nucleotide polymorphisms (SNPs) near the epidermal growth factor (EGF) (rs4444903), IL28B (rs12979860), and PNPLA3 (rs738409) loci are associated with treatment response, fibrosis, and hepatocellular carcinoma in non-transplant hepatitis C, but allograft population data are limited.
|
26854475 |
2016 |
|
rs4444903
|
|
Liver carcinoma
|
|
0.060 |
GeneticVariation
|
BEFREE |
The association between epidermal growth factor (EGF) gene +61A/G polymorphism (rs4444903) and hepatocellular carcinoma (HCC) susceptibility has been widely reported, but the results were inconsistent.
|
25927412 |
2015 |
|
rs4444903
|
|
Liver carcinoma
|
|
0.060 |
GeneticVariation
|
BEFREE |
Single nucleotide polymorphisms (SNPs) in the epidermal growth factor (EGF, rs4444903), patatin-like phospholipase domain-containing protein 3 (PNPLA3, rs738409) genes, and near the interleukin-28B (IL28B, rs12979860) gene are linked to treatment response, fibrosis, and hepatocellular carcinoma (HCC) in chronic hepatitis C. Whether these SNPs independently or in combination predict clinical deterioration in hepatitis C virus (HCV)-related cirrhosis is unknown.
|
25504078 |
2014 |
|
rs4444903
|
|
Liver carcinoma
|
|
0.060 |
GeneticVariation
|
BEFREE |
Additionally, the haplotype T-G constructed by rs11569017 and rs4444903 of the EGF gene might increase the risk of HBV-related HCC (p=0.002, OR=1.44, 95% CI=1.15-1.82).
|
23790025 |
2013 |
|
rs4444903
|
|
Liver carcinoma
|
|
0.060 |
GeneticVariation
|
BEFREE |
Previous work suggests an association between the EGF 61*A/G polymorphism (rs4444903) and susceptibility to hepatocellular carcinoma (HCC), but the results have been inconsistent.
|
22403631 |
2012 |
|
rs4444903
|
|
Liver carcinoma
|
|
0.060 |
GeneticVariation
|
BEFREE |
A single nucleotide polymorphism 61*G (rs4444903) in the epidermal growth factor (EGF) gene has been associated, in 2 case-control studies, with hepatocellular carcinoma (HCC).
|
21440548 |
2011 |
|
rs4444903
|
|
Hepatitis C
|
|
0.030 |
GeneticVariation
|
BEFREE |
Single nucleotide polymorphisms (SNPs) near the epidermal growth factor (EGF) (rs4444903), IL28B (rs12979860), and PNPLA3 (rs738409) loci are associated with treatment response, fibrosis, and hepatocellular carcinoma in non-transplant hepatitis C, but allograft population data are limited.
|
26854475 |
2016 |
|
rs4444903
|
|
Hepatitis C
|
|
0.030 |
GeneticVariation
|
BEFREE |
Single nucleotide polymorphisms (SNPs) in the epidermal growth factor (EGF, rs4444903), patatin-like phospholipase domain-containing protein 3 (PNPLA3, rs738409) genes, and near the interleukin-28B (IL28B, rs12979860) gene are linked to treatment response, fibrosis, and hepatocellular carcinoma (HCC) in chronic hepatitis C. Whether these SNPs independently or in combination predict clinical deterioration in hepatitis C virus (HCV)-related cirrhosis is unknown.
|
25504078 |
2014 |
|
rs4444903
|
|
Glioma
|
|
0.030 |
GeneticVariation
|
BEFREE |
Extensive studies have found that a single nucleotide polymorphism (SNP) +61 G/A (rs4444903) in the EGF gene is associated with the susceptibility of glioma, however, the results have been controversial.
|
24740103 |
2014 |
|
rs4444903
|
|
Glioma
|
|
0.030 |
GeneticVariation
|
BEFREE |
Overall, there was a significant association between EGF rs4444903 polymorphism and glioma</span> risk in all four genetic models (the allele model: OR=1.25, 95 % CI 1.15-1.37, P<0.001; the codominant model: OR=1.65, 95 % CI 1.36-1.99, P<0.001; the dominant model: OR=1.27, 95 % CI 1.12-1.44, P<0.001; the recessive model: OR=1.48, 95 % CI 1.25-1.75, P<0.001).
|
23645212 |
2013 |
|
rs4444903
|
|
Hepatitis C
|
|
0.030 |
GeneticVariation
|
BEFREE |
The present study was performed to assess the allelic and genotypic frequencies of the rs4444903 A>G polymorphism in patients with chronic hepatitis C virus HCV infection and to ascertain whether this polymorphism might be an independent predictor of the degree of fibrosis.
|
22122913 |
2012 |
|
rs4444903
|
|
Glioma
|
|
0.030 |
GeneticVariation
|
BEFREE |
Previous studies showed that the EGF +61G/A polymorphism (rs4444903) may lead to an alteration in EGF production and/or activity, which can result in individual susceptibility to glioma.
|
22829952 |
2012 |
|
rs4444903
|
|
Colorectal Carcinoma
|
|
0.020 |
GeneticVariation
|
BEFREE |
The genetic association between EGF A61G polymorphism (rs4444903) and risk of colorectal cancer: An update meta-analysis and trial sequential analysis.
|
30633190 |
2019 |
|
rs4444903
|
|
Malignant Neoplasms
|
|
0.020 |
GeneticVariation
|
BEFREE |
A functional single nucleotide polymorphism (SNP) in EGF promoter region (EGF+61 A>G-rs4444903) has been associated with cancer susceptibility.
|
30783937 |
2019 |
|
rs4444903
|
|
Primary malignant neoplasm
|
|
0.020 |
GeneticVariation
|
BEFREE |
A functional single nucleotide polymorphism (SNP) in EGF promoter region (EGF+61 A>G-rs4444903) has been associated with cancer susceptibility.
|
30783937 |
2019 |
|
rs4444903
|
|
Malignant neoplasm of colon and/or rectum
|
|
0.020 |
GeneticVariation
|
BEFREE |
The genetic association between EGF A61G polymorphism (rs4444903) and risk of colorectal cancer: An update meta-analysis and trial sequential analysis.
|
30633190 |
2019 |
|
rs4444903
|
|
melanoma
|
|
0.020 |
GeneticVariation
|
BEFREE |
Finally, the meta-analysis with 2167 cases/4211 controls showed that the EGF rs4444903 had no significant association with CM (p>0.05), while the analysis with 3,492 cases/5,381 controls indicated the A allele of XPD rs13181 was significantly associated with CM (odds ratio= 0.93, 95% CI: 0.87-0.99; p=0.019).
|
25537294 |
2015 |
|
rs4444903
|
|
Liver and Intrahepatic Biliary Tract Carcinoma
|
|
0.020 |
GeneticVariation
|
BEFREE |
In conclusion, the current meta-analysis suggests that the G variant of the rs4444903 polymorphism may increase</span> the risk of liver cancer.
|
25299191 |
2014 |
|
rs4444903
|
|
Adult Liver Carcinoma
|
|
0.020 |
GeneticVariation
|
BEFREE |
In conclusion, the current meta-analysis suggests that the G variant of the rs4444903 polymorphism may increase</span> the risk of liver cancer.
|
25299191 |
2014 |
|
rs4444903
|
|
Malignant neoplasm of liver
|
|
0.020 |
GeneticVariation
|
BEFREE |
In conclusion, the current meta-analysis suggests that the G variant of the rs4444903 polymorphism may increase</span> the risk of liver cancer.
|
25299191 |
2014 |
|
rs4444903
|
|
Liver Cirrhosis
|
|
0.020 |
GeneticVariation
|
BEFREE |
Single nucleotide polymorphisms (SNPs) in the epidermal growth factor (EGF, rs4444903), patatin-like phospholipase domain-containing protein 3 (PNPLA3, rs738409) genes, and near the interleukin-28B (IL28B, rs12979860) gene are linked to treatment response, fibrosis, and hepatocellular carcinoma (HCC) in chronic hepatitis C. Whether these SNPs independently or in combination predict clinical deterioration in hepatitis C virus (HCV)-related cirrhosis is unknown.
|
25504078 |
2014 |
|
rs4444903
|
|
Cirrhosis
|
|
0.020 |
GeneticVariation
|
BEFREE |
Single nucleotide polymorphisms (SNPs) in the epidermal growth factor (EGF, rs4444903), patatin-like phospholipase domain-containing protein 3 (PNPLA3, rs738409) genes, and near the interleukin-28B (IL28B, rs12979860) gene are linked to treatment response, fibrosis, and hepatocellular carcinoma (HCC) in chronic hepatitis C. Whether these SNPs independently or in combination predict clinical deterioration in hepatitis C virus (HCV)-related cirrhosis is unknown.
|
25504078 |
2014 |
|
rs4444903
|
|
melanoma
|
|
0.020 |
GeneticVariation
|
BEFREE |
Emerging evidence showed that the common polymorphism (+61A>G, rs4444903) in the promoter region of epidermal growth factor (EGF) gene might be associated with melanoma susceptibility in humans.
|
23201894 |
2013 |
|
rs4444903
|
|
Liver Cirrhosis
|
|
0.020 |
GeneticVariation
|
BEFREE |
In the longitudinal study, the EGF rs4444903 A > G polymorphism was found to be an independent predictor of cirrhosis development (O.R.7·73, 95% C.I.1·21-49·5, P = 0·007).
|
22236006 |
2012 |
|
rs4444903
|
|
Malignant neoplasm of colon and/or rectum
|
|
0.020 |
GeneticVariation
|
BEFREE |
For the rs4444903 SNP, no significant association (P value = 0.149) was found with colorectal cancer risk.
|
21567271 |
2012 |