|
rs8176719
|
|
Venous Thromboembolism
|
|
0.830 |
GeneticVariation
|
BEFREE |
Our findings suggest that the risk of VTE by FHMI is not explained by rs8176719 (ABO), rs6025 (F5), rs1799963 (F2), rs2066865 (FGG), and rs2036914 (F11).
|
31124268 |
2019 |
|
rs8176719
|
|
Venous Thromboembolism
|
|
0.830 |
GeneticVariation
|
BEFREE |
Our data suggest that SNPs ABO rs8176719 and FGG rs2066865 may contribute individually to the VTE susceptibility in the Portuguese population.
|
29995659 |
2018 |
|
rs8176719
|
|
Venous Thromboembolism
|
|
0.830 |
GeneticVariation
|
BEFREE |
ABO re-sequencing identified 15 novel single nucleotide variations (SNV) in ABO intron 6 and the ABO 3' UTR that were strongly associated with VTE (P<10(-4)) and belonged to three distinct linkage disequilibrium (LD) blocks; none were in LD with ABO rs8176719 or rs2519093.
|
22672568 |
2012 |
|
rs2519093
|
|
Venous Thromboembolism
|
|
0.820 |
GeneticVariation
|
BEFREE |
ABO re-sequencing identified 15 novel single nucleotide variations (SNV) in ABO intron 6 and the ABO 3' UTR that were strongly associated with VTE (P<10(-4)) and belonged to three distinct linkage disequilibrium (LD) blocks; none were in LD with ABO rs8176719 or rs2519093.
|
22672568 |
2012 |
|
rs2519093
|
|
Venous Thromboembolism
|
|
0.820 |
GeneticVariation
|
BEFREE |
Among 2927 individuals, one or more SNPs within ABO, F2, F5, F11, KLKB1, SELP and SCUBE1 were significantly associated with VTE, including factor (F) V Leiden, prothrombin G20210A, ABO non-O blood type, and a novel association with ABO rs2519093 (OR=1.68, P-value=8.08×10(-16) ) that was independent of blood type.
|
21463476 |
2011 |
|
rs505922
|
|
Duodenal Ulcer
|
|
0.810 |
GeneticVariation
|
BEFREE |
The T allele of rs2294008 encodes a translation initiation codon upstream of the reported site and changes protein localization from the cytoplasm to the cell surface. rs505922 at ABO was also associated with duodenal ulcer in a recessive model (OR = 1.32; P = 1.15 × 10(-10)).
|
22387998 |
2012 |
|
rs505922
|
|
Pancreatic carcinoma
|
|
0.740 |
GeneticVariation
|
BEFREE |
This study provided evidence of SNP rs505922 C allele as a strong risk factor of cancer susceptibility, specifically for pancreatic cancer.
|
25656610 |
2015 |
|
rs505922
|
|
Malignant neoplasm of pancreas
|
|
0.740 |
GeneticVariation
|
BEFREE |
This study provided evidence of SNP rs505922 C allele as a strong risk factor of cancer susceptibility, specifically for pancreatic cancer.
|
25656610 |
2015 |
|
rs505922
|
|
Malignant neoplasm of pancreas
|
|
0.740 |
GeneticVariation
|
BEFREE |
SNP rs505922, located within the first intron of the ABO gene, has been associated with the adenocarcinoma subtype of pancreatic cancer.
|
22642827 |
2012 |
|
rs505922
|
|
Pancreatic carcinoma
|
|
0.740 |
GeneticVariation
|
BEFREE |
SNP rs505922, located within the first intron of the ABO gene, has been associated with the adenocarcinoma subtype of pancreatic cancer.
|
22642827 |
2012 |
|
rs505922
|
|
Pancreatic carcinoma
|
|
0.740 |
GeneticVariation
|
BEFREE |
Consistent with earlier reports showing a higher risk of PC for individuals with the non-O blood type, the previously reported protective allele (T) for rs505922 was found to be strongly correlated (r(2) = 0.96) with the O allele.
|
21306478 |
2011 |
|
rs505922
|
|
Malignant neoplasm of pancreas
|
|
0.740 |
GeneticVariation
|
BEFREE |
Consistent with earlier reports showing a higher risk of PC for individuals with the non-O blood type, the previously reported protective allele (T) for rs505922 was found to be strongly correlated (r(2) = 0.96) with the O allele.
|
21306478 |
2011 |
|
rs505922
|
|
Malignant neoplasm of pancreas
|
|
0.740 |
GeneticVariation
|
BEFREE |
We identified an association between a locus on 9q34 and pancreatic cancer marked by the SNP rs505922 (combined P = 5.37 x 10(-8); multiplicative per-allele odds ratio 1.20; 95% confidence interval 1.12-1.28).
|
19648918 |
2009 |
|
rs505922
|
|
Pancreatic carcinoma
|
|
0.740 |
GeneticVariation
|
BEFREE |
We identified an association between a locus on 9q34 and pancreatic cancer marked by the SNP rs505922 (combined P = 5.37 x 10(-8); multiplicative per-allele odds ratio 1.20; 95% confidence interval 1.12-1.28).
|
19648918 |
2009 |
|
rs505922
|
|
Ischemic stroke
|
|
0.720 |
GeneticVariation
|
BEFREE |
We found that rs579459 and rs505922 within ABO gene and their interaction were both associated with increased IS risk in Chinese population.
|
28984382 |
2018 |
|
rs505922
|
|
Ischemic stroke
|
|
0.720 |
GeneticVariation
|
BEFREE |
SNP rs505922 was nominally associated with ischemic stroke (odds ratio = 0.94, 95% confidence interval = 0.88-0.99, p = 0.023).
|
23381943 |
2013 |
|
rs529565
|
|
Ischemic stroke
|
|
0.720 |
GeneticVariation
|
BEFREE |
We did not find any relation of rs651007 and rs529565 with IS risk in both additive and dominant models.
|
28984382 |
2018 |
|
rs529565
|
|
Ischemic stroke
|
|
0.720 |
GeneticVariation
|
BEFREE |
We selected four single nucleotide polymorphisms (rs579459, rs651007, rs514659 and rs529565) of the ABO gene and performed genotyping assays to assess the association with ischemic stroke and its subtypes.
|
27542834 |
2016 |
|
rs505922
|
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.710 |
GeneticVariation
|
BEFREE |
These data indicate that the previously identified elevated risk of type 2 diabetes for carriers of the <i>ABO</i> rs505922:C allele may be caused by decreased early-phase insulin secretion.
|
31537524 |
2019 |
|
rs505922
|
|
Cerebrovascular accident
|
|
0.020 |
GeneticVariation
|
BEFREE |
Although rs505922 was not associated with LAA stroke (TT genotype, adjusted OR = 1.32; 95 % CI, 0.94 to 1.87), two novel SNPs, rs8176668 (AT genotype, adjusted OR = 0.71; 95 % CI, 0.55 to 0.92) and rs2073824 (AA genotype, adjusted OR = 0.72; 95 % CI, 0.57 to 0.92), were associated with LAA stroke.
|
26924317 |
2017 |
|
rs505922
|
|
Primary malignant neoplasm
|
|
0.020 |
GeneticVariation
|
BEFREE |
This study provided evidence of SNP rs505922 C allele as a strong risk factor of cancer susceptibility, specifically for pancreatic cancer.
|
25656610 |
2015 |
|
rs505922
|
|
Malignant Neoplasms
|
|
0.020 |
GeneticVariation
|
BEFREE |
This study provided evidence of SNP rs505922 C allele as a strong risk factor of cancer susceptibility, specifically for pancreatic cancer.
|
25656610 |
2015 |
|
rs505922
|
|
Malignant Neoplasms
|
|
0.020 |
GeneticVariation
|
BEFREE |
Carriers of the C allele of rs505922 had an increased cancer risk [adjusted odds ratio (OR) = 1.42, 95% confidence interval (CI): 1.02-1.98] compared to TT carriers.
|
23816557 |
2014 |
|
rs505922
|
|
Primary malignant neoplasm
|
|
0.020 |
GeneticVariation
|
BEFREE |
Carriers of the C allele of rs505922 had an increased cancer risk [adjusted odds ratio (OR) = 1.42, 95% confidence interval (CI): 1.02-1.98] compared to TT carriers.
|
23816557 |
2014 |
|
rs505922
|
|
Cerebrovascular accident
|
|
0.020 |
GeneticVariation
|
BEFREE |
Independent replication in Meta-Stroke confirmed the rs505922 association with stroke, beta (standard error, SE) = 0.066 (0.02), p = 0.001, a finding specific to large-vessel and cardioembolic stroke (p = 0.001 and p = < 0.001, respectively) but not seen with small-vessel stroke (p = 0.811).
|
23381943 |
2013 |