|
rs2268388
|
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.050 |
GeneticVariation
|
BEFREE |
A single nucleotide polymorphism (SNP) within the acetyl CoA carboxylase (ACC) β gene (ACACB), rs2268388, has been shown to be associated with susceptibility to development of proteinuria in patients with type 2 diabetes.
|
29175208 |
2018 |
|
rs2268388
|
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.050 |
GeneticVariation
|
BEFREE |
Our meta-analysis supports that the ApoE ε2 allele and ACACB rs2268388 C>T might act as promotion factors of nephropathy in type 2 diabetes, whereas PPARγ rs1801282 C>G is a promising candidate genetic variation for reducing susceptibility to T2DN.
|
25262148 |
2015 |
|
rs2268388
|
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.050 |
GeneticVariation
|
BEFREE |
This study assessed relationships between rs2268388, body mass index (BMI) and gene expression in multiple populations, with and without T2</span>DM.
|
23460794 |
2013 |
|
rs2268388
|
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.050 |
GeneticVariation
|
BEFREE |
1,158 patients with T2DM belonging to two independently ascertained North Indian and one South Indian cohorts were genotyped for ACACβ (rs2268388) and AGTR1 (rs5186) polymorphism using real time PCR-based Taq-man assay and PCR-RFLP assays.
|
23081748 |
2013 |
|
rs2268388
|
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.050 |
GeneticVariation
|
BEFREE |
A meta-analysis revealed that rs2268388</span> was significantly associated with proteinuria in Japanese patients with type 2 diabetes (p = 5.35 x 10(-8), odds ratio = 1.61, 95% Cl: 1.35-1.91).
|
20168990 |
2010 |
|
rs2268388
|
|
Kidney Diseases
|
|
0.040 |
GeneticVariation
|
BEFREE |
The ACACB gene rs2268388 polymorphism is associated with nephropathy in Caucasian patients with diabetes: a meta-analysis.
|
26030797 |
2015 |
|
rs2268388
|
|
Kidney Diseases
|
|
0.040 |
GeneticVariation
|
BEFREE |
Our meta-analysis supports that the ApoE ε2 allele and ACACB rs2268388 C>T might act as promotion factors of nephropathy in type 2 diabetes, whereas PPARγ rs1801282 C>G is a promising candidate genetic variation for reducing susceptibility to T2DN.
|
25262148 |
2015 |
|
rs2268388
|
|
Kidney Diseases
|
|
0.040 |
GeneticVariation
|
BEFREE |
ACACβ gene (rs2268388) and AGTR1 gene (rs5186) polymorphism and the risk of nephropathy in Asian Indian patients with type 2 diabetes.
|
23081748 |
2013 |
|
rs2268388
|
|
Kidney Diseases
|
|
0.040 |
GeneticVariation
|
BEFREE |
Among subjects without T2DM, rs2268388 DN risk allele (T) associated with higher BMI in Pima Indian children (n = 2021; p-additive = 0.029) and African Americans (AAs) (n = 177; p-additive = 0.05), with a trend in European Americans (EAs) (n = 512; p-additive = 0.09), but not Germans (n = 858; p-additive = 0.765).
|
23460794 |
2013 |
|
rs2268388
|
|
Diabetes
|
|
0.030 |
GeneticVariation
|
BEFREE |
Our pooled data suggest a significant association exists between rs2268388 and diabetic nephropathy among Caucasian patients with diabetes.
|
26030797 |
2015 |
|
rs2268388
|
|
Diabetes Mellitus
|
|
0.030 |
GeneticVariation
|
BEFREE |
Our pooled data suggest a significant association exists between rs2268388 and diabetic nephropathy among Caucasian patients with diabetes.
|
26030797 |
2015 |
|
rs2268388
|
|
Diabetes
|
|
0.030 |
GeneticVariation
|
BEFREE |
Likewise, T alleles at the rs2268388 locus and C alleles at the rs2239607 locus were associated with diabetes, in the discovery as well as in the replication cohorts, even after women with severe obesity were excluded (OR 3.6 and 2.8, for TT and CC homozygotes, respectively).
|
21908218 |
2011 |
|
rs2268388
|
|
Diabetes Mellitus
|
|
0.030 |
GeneticVariation
|
BEFREE |
Likewise, T alleles at the rs2268388 locus and C alleles at the rs2239607 locus were associated with diabetes, in the discovery as well as in the replication cohorts, even after women with severe obesity were excluded (OR 3.6 and 2.8, for TT and CC homozygotes, respectively).
|
21908218 |
2011 |
|
rs2268388
|
|
Diabetes
|
|
0.030 |
GeneticVariation
|
BEFREE |
Adjusting for age, gender and diabetes duration, ACACB SNP rs2268388 was significantly associated with advanced T2DN (odds ratio = 2.39; recessive model; P = 0.0129).
|
20519229 |
2010 |
|
rs2268388
|
|
Diabetes Mellitus
|
|
0.030 |
GeneticVariation
|
BEFREE |
Adjusting for age, gender and diabetes duration, ACACB SNP rs2268388 was significantly associated with advanced T2DN (odds ratio = 2.39; recessive model; P = 0.0129).
|
20519229 |
2010 |
|
rs2241220
|
|
Hypercholesterolemia
|
|
0.020 |
GeneticVariation
|
BEFREE |
Neuropeptide Y (NPY) gene (rs1468271) and ACACB gene (rs2241220) SNPs were significantly associated with severe hypercholesterolemia.
|
19846279 |
2009 |
|
rs2241220
|
|
Hypercholesterolemia
|
|
0.020 |
GeneticVariation
|
BEFREE |
Known physiological mechanisms were supported for 3 associations found in patients taking olanzapine, quetiapine or chlorpromazine [acetyl-coenzyme A carboxylase alpha SNP (rs4072032) in the hypertriglyceridemia model, and for the neuropeptide Y (rs1468271) and ACCbeta, (rs2241220) in the hypercholesterolemia model].
|
18031993 |
2008 |
|
rs2268388
|
|
Diabetic Nephropathy
|
|
0.020 |
GeneticVariation
|
BEFREE |
Our pooled data suggest a significant association exists between rs2268388 and diabetic nephropathy among Caucasian patients with diabetes.
|
26030797 |
2015 |
|
rs2268388
|
|
Diabetic Nephropathy
|
|
0.020 |
GeneticVariation
|
BEFREE |
The present study was designed with the aim to examine the association of an ACACβ (rs2268388) and AGTR1 (rs5186) gene polymorphism with the risk of DN in Asian Indians.
|
23081748 |
2013 |
|
rs2239607
|
|
Diabetes Mellitus
|
|
0.010 |
GeneticVariation
|
BEFREE |
Likewise, T alleles at the rs2268388 locus and C alleles at the rs2239607 locus were associated with diabetes, in the discovery as well as in the replication cohorts, even after women with severe obesity were excluded (OR 3.6 and 2.8, for TT and CC homozygotes, respectively).
|
21908218 |
2011 |
|
rs2239607
|
|
Diabetes
|
|
0.010 |
GeneticVariation
|
BEFREE |
Likewise, T alleles at the rs2268388 locus and C alleles at the rs2239607 locus were associated with diabetes, in the discovery as well as in the replication cohorts, even after women with severe obesity were excluded (OR 3.6 and 2.8, for TT and CC homozygotes, respectively).
|
21908218 |
2011 |
|
rs2239607
|
|
Obesity, Morbid
|
|
0.010 |
GeneticVariation
|
BEFREE |
Likewise, T alleles at the rs2268388 locus and C alleles at the rs2239607 locus were associated with diabetes, in the discovery as well as in the replication cohorts, even after women with severe obesity were excluded (OR 3.6 and 2.8, for TT and CC homozygotes, respectively).
|
21908218 |
2011 |
|
rs2241220
|
|
Hypertriglyceridemia
|
|
0.010 |
GeneticVariation
|
BEFREE |
Known physiological mechanisms were supported for 3 associations found in patients taking olanzapine, quetiapine or chlorpromazine [acetyl-coenzyme A carboxylase alpha SNP (rs4072032) in the hypertriglyceridemia model, and for the neuropeptide Y (rs1468271) and ACCbeta, (rs2241220) in the hypercholesterolemia model].
|
18031993 |
2008 |
|
rs2268388
|
|
Obesity, Morbid
|
|
0.010 |
GeneticVariation
|
BEFREE |
T alleles at the rs2268388 locus were overrepresented in women with severe obesity (18% vs. 10% in controls; OR 1.74 [95% confidence interval 1.30-2.47]), which was statistically significant after multiple-test adjustment (p=0.0004).
|
21908218 |
2011 |
|
rs4766587
|
|
Metabolic Syndrome X
|
|
0.010 |
GeneticVariation
|
BEFREE |
In conclusion, the ACC2 rs4766587 polymorphism influences MetS risk, which was modulated by dietary fat, suggesting novel gene-nutrient interactions.
|
20855566 |
2010 |