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rs1445888481
|
|
Amyotrophic Lateral Sclerosis
|
|
0.100 |
GeneticVariation
|
BEFREE |
Peroxynitrite Activates the NLRP3 Inflammasome Cascade in SOD1(G93A) Mouse Model of Amyotrophic Lateral Sclerosis.
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28357805 |
2018 |
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rs1445888481
|
|
Amyotrophic Lateral Sclerosis
|
|
0.100 |
GeneticVariation
|
BEFREE |
The PRR NLRC4, caspase 1 and IL1β were significantly elevated in denervated muscle of SOD1<sup>(G93A)</sup> mice and sALS patients.
|
29575052 |
2018 |
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rs1445888481
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|
Amyotrophic Lateral Sclerosis
|
|
0.100 |
GeneticVariation
|
BEFREE |
Neurodegeneration and NLRP3 inflammasome expression in the anterior thalamus of SOD1(G93A) ALS mice.
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27880990 |
2018 |
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rs1445888481
|
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Amyotrophic Lateral Sclerosis
|
|
0.100 |
GeneticVariation
|
BEFREE |
Inflammasome activation was recently shown in the spinal cord of human sporadic ALS patients and in the SOD1(G93A) mouse model for ALS.
|
27957680 |
2017 |
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rs1445888481
|
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Amyotrophic Lateral Sclerosis
|
|
0.100 |
GeneticVariation
|
BEFREE |
Here, we show the therapeutic benefits of a modified peptide agonist stearyl-norleucine-VIP (SNV) in a transgenic rat model of amyotrophic lateral sclerosis (mutated superoxide dismutase 1, hSOD1(G93A)).
|
25311268 |
2015 |
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rs1445888481
|
|
Amyotrophic Lateral Sclerosis
|
|
0.100 |
GeneticVariation
|
BEFREE |
In this study, we investigated the expression, activation and co-localization of the NLRP3 inflammasome in the spinal cord of male SOD1(G93A) mice carrying a mutant human superoxide dismutase 1 (SOD1) variant and regarded as an animal model for ALS as well as in post-mortem tissue of ALS patients.
|
26200799 |
2015 |
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rs1445888481
|
|
Amyotrophic Lateral Sclerosis
|
|
0.100 |
GeneticVariation
|
BEFREE |
Erythropoietin modulates the immune-inflammatory response of a SOD1(G93A) transgenic mouse model of amyotrophic lateral sclerosis (ALS).
|
24820540 |
2014 |
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rs1445888481
|
|
Amyotrophic Lateral Sclerosis
|
|
0.100 |
GeneticVariation
|
BEFREE |
Here, to investigate the role of proliferating cells in motor neuron disease, SOD1(G93A) transgenic mice were treated intracerebroventicularly (i.c.v.) with the anti-mitotic drug cytosine arabinoside (Ara-C).I.c.v. delivery of Ara-C accelerated disease progression in SOD1(G93A) mouse model of ALS.
|
22523565 |
2012 |
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rs1445888481
|
|
Amyotrophic Lateral Sclerosis
|
|
0.100 |
GeneticVariation
|
BEFREE |
We show here that the expression of caspase-11 is upregulated in the spinal cord of superoxide dismutase 1 (SOD1) G93A transgenic mice, a mouse model of amyotrophic lateral sclerosis (ALS), before the onset of motor dysfunction and remains at the high levels throughout the course of disease.
|
12843244 |
2003 |
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rs1445888481
|
|
Amyotrophic Lateral Sclerosis
|
|
0.100 |
GeneticVariation
|
BEFREE |
Temporal patterns of cytokine and apoptosis-related gene expression in spinal cords of the G93A-SOD1 mouse model of amyotrophic lateral sclerosis.
|
12124437 |
2002 |
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rs16944
|
|
Schizophrenia
|
|
0.060 |
GeneticVariation
|
BEFREE |
We have found a trend toward an association of rs1143627, rs16944, rs1143623 in IL1B gene with the risk of schizophrenia.
|
28083609 |
2016 |
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rs16944
|
|
Schizophrenia
|
|
0.060 |
GeneticVariation
|
BEFREE |
Moreover, our meta-analysis results showed no significant association between the common SNV, rs16944, and schizophrenia.
|
24155145 |
2014 |
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rs16944
|
|
Schizophrenia
|
|
0.060 |
GeneticVariation
|
BEFREE |
The present study examined the effects of a functional polymorphism at IL1B gene promoter (-511C/T; rs16944) on brain correlates of working memory performance in schizophrenia.
|
22763186 |
2012 |
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rs16944
|
|
Schizophrenia
|
|
0.060 |
GeneticVariation
|
BEFREE |
A trend towards association was also found between rs16944 and female patients with schizophrenia (P = 0.032).
|
21843369 |
2011 |
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rs16944
|
|
Schizophrenia
|
|
0.060 |
GeneticVariation
|
BEFREE |
The combined allele-wise odds ratio (OR) for schizophrenia of the rs16944 (IL1B gene; T-511C) polymorphism was 0.86 (95% CI: 0.77to 0.96).When applying stratified analysis to this polymorphism, the pooled allele-wise OR was 0.88 (95% CI, 0.79 to 0.97) in 10 population-based studies and 0.85 (95% CI: 0.73 to 0.99) in Caucasian samples.
|
20347268 |
2010 |
|
rs16944
|
|
Schizophrenia
|
|
0.060 |
GeneticVariation
|
BEFREE |
However, meta-analysis of our data combined with previously published association studies of rs16944 (IL1beta -511) suggests that the C allele confers modest risk for schizophrenia among individuals reporting Caucasian ancestry, but not Asians (Caucasians, n=819 cases, 1292 controls; p=0.0013, OR=1.24, 95% CI 1.09, 1.41).
|
16905295 |
2006 |
|
rs1143634
|
|
Chronic Periodontitis
|
|
0.040 |
GeneticVariation
|
BEFREE |
We found that the statistically significant association of IL1A-889C/T (rs1800587), IL1B -31C/T (rs1143627), IL1B -511A/G (rs16944) and IL1B + 3954C/T (rs1143634) gene polymorphisms with increased susceptibility of chronic periodontitis.
|
30939298 |
2019 |
|
rs1143634
|
|
Chronic Periodontitis
|
|
0.040 |
GeneticVariation
|
BEFREE |
This meta-analysis in 9376 participants with 54 case/control studies revealed the rs1143634 polymorphism was associated with elevated risk of chronic periodontitis in overall analysis as well as Caucasian and Asian ethnicities and Mixed population.
|
29783069 |
2018 |
|
rs1143634
|
|
Chronic Periodontitis
|
|
0.040 |
GeneticVariation
|
BEFREE |
In conclusion, literature review suggests that for IL1B SNP rs1143634, EARR and CP have an opposite genetic profile.
|
30142580 |
2018 |
|
rs1143634
|
|
Chronic Periodontitis
|
|
0.040 |
GeneticVariation
|
BEFREE |
Although the present results do not support that IL-1B (rs1143634) SNP could be identified as a risk predictor for CP in the present population, the synergistic interaction of the CT/CC genotypes of NLRP3 (rs4612666) SNP with ageing and/or smoking habit potentially might play a significant role in the pathogenic pathways of periodontal disease.
|
26854620 |
2016 |
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rs16944
|
|
Multiple Sclerosis
|
|
0.040 |
GeneticVariation
|
BEFREE |
We found that the expression level of IL-1B in MS patients increased 3.336 times more than controls in PBMCs but the rs16944 SNP in the promoter region of IL-1B did not affect the expression level of this gene and there was not association of this SNP with MS in the examined population.
|
24867167 |
2014 |
|
rs16944
|
|
Multiple Sclerosis
|
|
0.040 |
GeneticVariation
|
BEFREE |
No association was found between the IL-1α -889 (rs1800587), IL-1α +4,845 (rs17561), IL-1β -511 (rs16944), IL-1β +3,953 (rs1143634), IL-1ra variable number tandem repeat (VNTR) polymorphisms and MS risk.
|
23052182 |
2013 |
|
rs16944
|
|
Multiple Sclerosis
|
|
0.040 |
GeneticVariation
|
BEFREE |
Single nucleotide polymorphisms in human pro- and anti-inflammatory genes, including IL1RN VNTR (rs315952), IL1A 4845G>T (rs17561), L1B-511C>T (rs16944), IL6-174G>C (rs1800795), IL10-1082 A>G (rs 1800896) and TNFα-308G>A (rs1800629) and their impact on multiple sclerosis risk and disease progression in a Polish population were investigated.
|
21621860 |
2011 |
|
rs16944
|
|
Multiple Sclerosis
|
|
0.040 |
GeneticVariation
|
BEFREE |
With respect to MS, IL-1 beta (-511 C/T; rs16944), IL-1 beta (+3954 C/T; rs1143634), IL-1 alpha (-889 C/T; rs1800587), IL-1 alpha (+4845 G/T; rs17561), and the variable number of tandem repeats in intron 2 of the IL-1 receptor antagonist (IL-1RN) gene polymorphisms have been studied in different ethnic groups, leading to conflicting results.
|
20192980 |
2010 |
|
rs1143623
|
|
Colorectal Carcinoma
|
|
0.030 |
GeneticVariation
|
BEFREE |
Stratified analyses revealed the IL-1B gene rs11</span>43623 and rs1143634 polymorphisms decreased the risk of CR</span>C among females, smokers and drinkers.
|
30563955 |
2018 |