|
rs142117234
|
|
Asthma
|
A |
0.700 |
GeneticVariation
|
GWASCAT |
Shared genetics of asthma and mental health disorders: a large-scale genome-wide cross-trait analysis.
|
31619474 |
2019 |
|
rs2243250
|
|
Asthma
|
|
0.060 |
GeneticVariation
|
BEFREE |
A four-way gene-gene interaction model consisting of IL13 rs20541, IL4 rs2243250</span>, ADRB2 rs1042713, and FCER1B rs569108 was chosen as the optimal one for determining asthma susceptibility (testing balanced accuracy = 0.6089, cross-validation consistency = 10/10, P = 6.98E-05).
|
26613553 |
2016 |
|
rs2243250
|
|
Asthma
|
|
0.060 |
GeneticVariation
|
BEFREE |
IL-4 rs2243250 and rs2070874 allele and genotype frequencies did not significantly differ between the asthma and control groups (P > 0.05), but those of IL-4R rs1801275 did (P < 0.05).
|
27819719 |
2016 |
|
rs2243250
|
|
Asthma
|
|
0.060 |
GeneticVariation
|
BEFREE |
rs2243250 and rs2227284 are significantly associated with asthma and allergic rhinitis.
|
23654077 |
2013 |
|
rs2243250
|
|
Asthma
|
|
0.060 |
GeneticVariation
|
BEFREE |
Polymorphisms rs2243250 and rs2070874 of IL-4 and rs1801275 and rs1805011 of IL4R were associated with asthma.
|
23924473 |
2013 |
|
rs2243250
|
|
Asthma
|
|
0.060 |
GeneticVariation
|
BEFREE |
No evident relationships were found between rs2243250, rs2070874, or rs2227284 and asthma.
|
23964553 |
2013 |
|
rs2243250
|
|
Asthma
|
|
0.060 |
GeneticVariation
|
BEFREE |
Interleukin-4 rs2243250 polymorphism is associated with asthma among Caucasians and related to atopic asthma.
|
22652416 |
2012 |
|
rs2070874
|
|
Asthma
|
|
0.050 |
GeneticVariation
|
BEFREE |
IL-4 rs2243250 and rs2070874 allele and genotype frequencies did not significantly differ between the asthma and control groups (P > 0.05), but those of IL-4R rs1801275 did (P < 0.05).
|
27819719 |
2016 |
|
rs2070874
|
|
Asthma
|
|
0.050 |
GeneticVariation
|
BEFREE |
Individuals who carried the C allele for rs2070874 of the IL4 gene demonstrated increased asthma risk compared to TT homozygotes.
|
23924473 |
2013 |
|
rs2070874
|
|
Asthma
|
|
0.050 |
GeneticVariation
|
BEFREE |
A total of 214 atopic patients (108 with asthma and 106 with allergic rhinitis) and 120 healthy controls from Pakistan were genotyped for IL-4 SNPs C-589T (rs2243250), T+2979G (rs2227284), and C-33T (rs2070874) using restriction fragment length polymorphism-polymerase chain reaction.
|
23654077 |
2013 |
|
rs2070874
|
|
Asthma
|
|
0.050 |
GeneticVariation
|
BEFREE |
No evident relationships were found between rs2243250, rs2070874, or rs2227284 and asthma.
|
23964553 |
2013 |
|
rs2070874
|
|
Asthma
|
|
0.050 |
GeneticVariation
|
BEFREE |
In the present study, we confirmed the association of rs1800469 in TGF-beta1 and rs20541 in IL-13 with asthma and found a trend toward association between rs2241712 in TGF-beta1 and rs2070874 in IL-4 with asthma among atopic subjects, suggesting TGF-beta1, IL-4 and IL-13 may be associated with the susceptibility and development of asthma in this Chinese population.
|
22053598 |
2011 |
|
rs2227284
|
|
Asthma
|
|
0.030 |
GeneticVariation
|
BEFREE |
We found a significant association of IL2 rs6534349 polymorphism with increased asthma risk (heterozygotes, P=.029; homozygous variants; P=.013) and of IL4 rs2227284 polymorphism with reduced asthma risk (heterozygotes, P=.026; homozygous variants; P=.001).
|
25747600 |
2015 |
|
rs2227284
|
|
Asthma
|
|
0.030 |
GeneticVariation
|
BEFREE |
rs2243250 and rs2227284 are significantly associated with asthma and allergic rhinitis.
|
23654077 |
2013 |
|
rs2227284
|
|
Asthma
|
|
0.030 |
GeneticVariation
|
BEFREE |
No evident relationships were found between rs2243250, rs2070874, or rs2227284 and asthma.
|
23964553 |
2013 |
|
rs2243250
|
|
Multiple Sclerosis
|
|
0.030 |
GeneticVariation
|
BEFREE |
The present case-control study inspected the association between seven single nucleotide polymorphisms (SNPs) of IL4 (IL4<sub>-1098</sub>: rs2243248, IL4<sub>-590</sub>: rs2243250, and IL4<sub>-33</sub>: rs2070874), IL4RA (IL4RA<sub>+1902</sub>: rs1801275), and IL10 (IL10<sub>-1082</sub>: rs1800896, IL10<sub>-819</sub>: rs1800871, and IL10<sub>-592</sub>: rs1800872) genes and MS in Iraqi patients.
|
31264107 |
2019 |
|
rs2243250
|
|
Allergic rhinitis (disorder)
|
|
0.030 |
GeneticVariation
|
BEFREE |
Haplotype analysis showed a significantly increased AR risk associated with the haplotype G-T-T (rs7130588-rs2155219-rs7927894) and a protective effect with the haplotype C-G-C (rs2243250-rs2227284-s2243290).
|
30170133 |
2018 |
|
rs2243250
|
|
Multiple Sclerosis
|
|
0.030 |
GeneticVariation
|
BEFREE |
The meta-analysis indicates that the T allele, CT and TT genotype of polymorphism of IL4 rs2243250 (C/T) may reduce the risk of MS in Caucasian populations, while polymorphisms of IL4 I3(709)*VNTR and IL4R rs1801275 may not associated with risk of MS in Caucasian populations.
|
27000232 |
2016 |
|
rs2243250
|
|
Allergic rhinitis (disorder)
|
|
0.030 |
GeneticVariation
|
BEFREE |
GG/CC/CC and TT/TT/TT (rs2243248, rs2243250, and rs2070874) haplotypes in the IL-4 gene had a significant negative correlation with AR.
|
24075353 |
2014 |
|
rs2243250
|
|
Allergic rhinitis (disorder)
|
|
0.030 |
GeneticVariation
|
BEFREE |
rs2243250 and rs2227284 are significantly associated with asthma and allergic rhinitis.
|
23654077 |
2013 |
|
rs2243250
|
|
Multiple Sclerosis
|
|
0.030 |
GeneticVariation
|
BEFREE |
The interleukin 4 promoter polymorphism -589 C/T (rs2243250) was genotyped in 869 multiple sclerosis (MS) patients and 595 healthy blood donors.
|
17855802 |
2007 |
|
rs2070874
|
|
Malignant Neoplasms
|
|
0.020 |
GeneticVariation
|
BEFREE |
In the subgroup analysis by cancer type, rs2243250 polymorphism was demonstrated to be associated with an increased risk of gastric cancer and breast cancer, rs2070874 polymorphism was correlated with leukemia and oral carcinoma, and rs79071878 polymorphism was relevant to bladder carcinoma risk.
|
28656227 |
2017 |
|
rs2070874
|
|
Primary malignant neoplasm
|
|
0.020 |
GeneticVariation
|
BEFREE |
In the subgroup analysis by ethnicity, IL‑4 rs2243250 polymorphism was demonstrated to be associated with cancer risk in both Caucasian and Asian populations, rs2070874 was associated with cancer risk in Asian populations, while rs79071878 polymorphism was associated with cancer risk in Caucasian populations.
|
28656227 |
2017 |
|
rs2070874
|
|
Respiratory Tract Infections
|
|
0.020 |
GeneticVariation
|
BEFREE |
Association between the TT-genotype of IL-4 rs2070874 polymorphism and a severe phenotype of viral-induced wheeze further underlines the role IL-4 plays in the inflammation pathway leading to viral respiratory infections.
|
28950434 |
2017 |
|
rs2070874
|
|
Respiratory Tract Infections
|
|
0.020 |
GeneticVariation
|
BEFREE |
One single-nucleotide polymorphism from IL4 gene was significant for pooled respiratory infections (rs2070874; 1.66 [1.29-2.14]).
|
26524966 |
2015 |