Source: GWASDB

Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs2228145
rs2228145
IL6R
CUI: C0003873
Disease: Rheumatoid Arthritis
Rheumatoid Arthritis 		A 0.850 GeneticVariation GWASDB Genetics of rheumatoid arthritis contributes to biology and drug discovery. 24390342

2014
dbSNP: rs2228145
rs2228145
IL6R
CUI: C0003873
Disease: Rheumatoid Arthritis
Rheumatoid Arthritis 		0.850 GeneticVariation GWASDB High-density genetic mapping identifies new susceptibility loci for rheumatoid arthritis. 23143596

2012
dbSNP: rs4129267
rs4129267
IL6R
CUI: C0004096
Disease: Asthma
Asthma 		T 0.820 GeneticVariation GWASDB Two loci were confirmed to associate with asthma risk in the replication cohorts and reached genome-wide significance in the combined analysis of all available studies (n=57,800): rs4129267 (OR 1·09, combined p=2·4×10(-8)) in the interleukin-6 receptor (IL6R) gene and rs7130588 (OR 1·09, p=1·8×10(-8)) on chromosome 11q13.5 near the leucine-rich repeat containing 32 gene (LRRC32, also known as GARP). 21907864

2011
dbSNP: rs2228145
rs2228145
IL6R
CUI: C0201657
Disease: C-reactive protein measurement
C-reactive protein measurement 		0.800 GeneticVariation GWASDB Gene-centric analysis identifies variants associated with interleukin-6 levels and shared pathways with other inflammation markers. 23505291

2013
dbSNP: rs2228145
rs2228145
IL6R
CUI: C0201657
Disease: C-reactive protein measurement
C-reactive protein measurement 		0.800 GeneticVariation GWASDB Loci related to metabolic-syndrome pathways including LEPR,HNF1A, IL6R, and GCKR associate with plasma C-reactive protein: the Women's Genome Health Study. 18439548

2008
dbSNP: rs2229238
rs2229238
IL6R
CUI: C0010068
Disease: Coronary heart disease
Coronary heart disease 		0.800 GeneticVariation GWASDB A genome-wide association study for coronary artery disease identifies a novel susceptibility locus in the major histocompatibility complex. 22319020

2012
dbSNP: rs4129267
rs4129267
IL6R
CUI: C0201657
Disease: C-reactive protein measurement
C-reactive protein measurement 		0.800 GeneticVariation GWASDB Gene-centric analysis identifies variants associated with interleukin-6 levels and shared pathways with other inflammation markers. 23505291

2013
dbSNP: rs4129267
rs4129267
IL6R
CUI: C0337428
Disease: Fibrinogen assay
Fibrinogen assay 		T 0.800 GeneticVariation GWASDB Multiethnic meta-analysis of genome-wide association studies in >100 000 subjects identifies 23 fibrinogen-associated Loci but no strong evidence of a causal association between circulating fibrinogen and cardiovascular disease. 23969696

2013
dbSNP: rs4129267
rs4129267
IL6R
CUI: C0337428
Disease: Fibrinogen assay
Fibrinogen assay 		0.800 GeneticVariation GWASDB Association of genomic loci from a cardiovascular gene SNP array with fibrinogen levels in European Americans and African-Americans from six cohort studies: the Candidate Gene Association Resource (CARe). 20978265

2011
dbSNP: rs4129267
rs4129267
IL6R
CUI: C0201657
Disease: C-reactive protein measurement
C-reactive protein measurement 		C 0.800 GeneticVariation GWASDB Meta-analysis of genome-wide association studies in >80 000 subjects identifies multiple loci for C-reactive protein levels. 21300955

2011
dbSNP: rs4537545
rs4537545
IL6R
CUI: C0201657
Disease: C-reactive protein measurement
C-reactive protein measurement 		0.800 GeneticVariation GWASDB Gene-centric analysis identifies variants associated with interleukin-6 levels and shared pathways with other inflammation markers. 23505291

2013
dbSNP: rs4537545
rs4537545
IL6R
CUI: C0201657
Disease: C-reactive protein measurement
C-reactive protein measurement 		T 0.800 GeneticVariation GWASDB Genetic Loci associated with C-reactive protein levels and risk of coronary heart disease. 19567438

2009
dbSNP: rs4845625
rs4845625
IL6R
CUI: C1956346
Disease: Coronary Artery Disease
Coronary Artery Disease 		0.800 GeneticVariation GWASDB Large-scale association analysis identifies new risk loci for coronary artery disease. 23202125

2013
dbSNP: rs12089132
rs12089132
IL6R ; IL6R-AS1
CUI: C0392885
Disease: High density lipoprotein measurement
High density lipoprotein measurement 		0.700 GeneticVariation GWASDB Large-scale gene-centric meta-analysis across 32 studies identifies multiple lipid loci. 23063622

2012
dbSNP: rs12089132
rs12089132
IL6R ; IL6R-AS1
CUI: C0428472
Disease: Serum HDL cholesterol measurement
Serum HDL cholesterol measurement 		0.700 GeneticVariation GWASDB Large-scale gene-centric meta-analysis across 32 studies identifies multiple lipid loci. 23063622

2012
dbSNP: rs1552481
rs1552481
IL6R ; IL6R-AS1
CUI: C0392885
Disease: High density lipoprotein measurement
High density lipoprotein measurement 		0.700 GeneticVariation GWASDB Large-scale gene-centric meta-analysis across 32 studies identifies multiple lipid loci. 23063622

2012
dbSNP: rs1552481
rs1552481
IL6R ; IL6R-AS1
CUI: C0428472
Disease: Serum HDL cholesterol measurement
Serum HDL cholesterol measurement 		0.700 GeneticVariation GWASDB Large-scale gene-centric meta-analysis across 32 studies identifies multiple lipid loci. 23063622

2012
dbSNP: rs2228145
rs2228145
IL6R
CUI: C1325327
Disease: fibrinogen activity
fibrinogen activity 		0.700 GeneticVariation GWASDB Gene-centric analysis identifies variants associated with interleukin-6 levels and shared pathways with other inflammation markers. 23505291

2013
dbSNP: rs2228145
rs2228145
IL6R
CUI: C1561955
Disease: Fibrinogen, CTCAE
Fibrinogen, CTCAE 		0.700 GeneticVariation GWASDB Gene-centric analysis identifies variants associated with interleukin-6 levels and shared pathways with other inflammation markers. 23505291

2013
dbSNP: rs2228145
rs2228145
IL6R
CUI: C0337428
Disease: Fibrinogen assay
Fibrinogen assay 		0.700 GeneticVariation GWASDB Gene-centric analysis identifies variants associated with interleukin-6 levels and shared pathways with other inflammation markers. 23505291

2013
dbSNP: rs2228145
rs2228145
IL6R
CUI: C1325327
Disease: fibrinogen activity
fibrinogen activity 		C 0.700 GeneticVariation GWASDB Novel loci, including those related to Crohn disease, psoriasis, and inflammation, identified in a genome-wide association study of fibrinogen in 17 686 women: the Women's Genome Health Study. 20031577

2009
dbSNP: rs2228145
rs2228145
IL6R
CUI: C1561955
Disease: Fibrinogen, CTCAE
Fibrinogen, CTCAE 		C 0.700 GeneticVariation GWASDB Novel loci, including those related to Crohn disease, psoriasis, and inflammation, identified in a genome-wide association study of fibrinogen in 17 686 women: the Women's Genome Health Study. 20031577

2009
dbSNP: rs2228145
rs2228145
IL6R
CUI: C0337428
Disease: Fibrinogen assay
Fibrinogen assay 		C 0.700 GeneticVariation GWASDB Novel loci, including those related to Crohn disease, psoriasis, and inflammation, identified in a genome-wide association study of fibrinogen in 17 686 women: the Women's Genome Health Study. 20031577

2009
dbSNP: rs28638007
rs28638007
IL6R
CUI: C0201657
Disease: C-reactive protein measurement
C-reactive protein measurement 		0.700 GeneticVariation GWASDB Gene-centric analysis identifies variants associated with interleukin-6 levels and shared pathways with other inflammation markers. 23505291

2013
dbSNP: rs4129267
rs4129267
IL6R
CUI: C1561955
Disease: Fibrinogen, CTCAE
Fibrinogen, CTCAE 		T 0.700 GeneticVariation GWASDB Multiethnic meta-analysis of genome-wide association studies in >100 000 subjects identifies 23 fibrinogen-associated Loci but no strong evidence of a causal association between circulating fibrinogen and cardiovascular disease. 23969696

2013