|
rs4705342
|
|
Ischemic stroke
|
|
0.020 |
GeneticVariation
|
BEFREE |
However, the three other miRNA (miR-143 rs4705342, miR-122 rs17669, and miR-124 r531564) were not associated with IS risk under allele or genotype, nor in different inheritance models.
|
30895838 |
2019 |
|
rs4705342
|
|
Ischemic stroke
|
|
0.020 |
GeneticVariation
|
BEFREE |
We found for the first time that the rs4705342 CC was a protective factor for IS, probably by reducing the level of miR-145.
|
27708363 |
2016 |
|
rs17723799
|
|
Lymphoma, Non-Hodgkin
|
|
0.010 |
GeneticVariation
|
BEFREE |
We identified three SNPs in MIR143 that are to be significantly associated with reduced risk of NHL: rs3733846 (odds ratio (OR) [95% confidence interval (CI)] = 0.54 [0.33 ⁻ 0.86], p = 0.010), rs41291957 (OR [95% CI] = 0.61 [0.39 ⁻ 0.94], p = 0.024), and rs17723799 (OR [95% CI] = 0.43 [0.26 ⁻ 0.71], p = 0.0009).
|
30818878 |
2019 |
|
rs353292
|
|
Conotruncal defect
|
|
0.010 |
GeneticVariation
|
BEFREE |
We investigated the association of these two single-nucleotide polymorphisms (SNPs) in the promoter of <i>miR-143/145</i> (rs353292 and rs4705343) with the susceptibility to CTDs in a Chinese population.
|
31691635 |
2019 |
|
rs353292
|
|
Colorectal Carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
We found that the rs353292 polymorphism was associated with an increased risk for developing CRC in heterozygous comparison (adjusted OR = 1.70, 95% CI, 1.32-2.20, P < 0.001), dominant genetic model (adjusted OR = 1.62, 95% CI, 1.26-2.09, P < 0.001), and allele comparison (adjusted OR = 1.46, 95% CI, 1.16-1.84, P = 0.001).
|
27444415 |
2016 |
|
rs353292
|
|
Malignant neoplasm of colon and/or rectum
|
|
0.010 |
GeneticVariation
|
BEFREE |
A functional variant rs353292 in the flanking region of miR-143/145 contributes to the risk of colorectal cancer.
|
27444415 |
2016 |
|
rs353293
|
|
Carcinoma of bladder
|
|
0.010 |
GeneticVariation
|
BEFREE |
These findings suggest that the functional rs353293 polymorphism may be a useful biomarker to predict the risk of bladder cancer.
|
27438131 |
2016 |
|
rs353293
|
|
Bladder Neoplasm
|
|
0.010 |
GeneticVariation
|
BEFREE |
These findings suggest that the functional rs353293 polymorphism may be a useful biomarker to predict the risk of bladder cancer.
|
27438131 |
2016 |
|
rs353293
|
|
Malignant neoplasm of urinary bladder
|
|
0.010 |
GeneticVariation
|
BEFREE |
These findings suggest that the functional rs353293 polymorphism may be a useful biomarker to predict the risk of bladder cancer.
|
27438131 |
2016 |
|
rs353293
|
|
Colorectal Carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
The mutant genotypes or alleles of rs41291957, rs353292, rs353293, and rs4705341 were significantly associated with an increased risk of CRC compared with the wild genotypes or alleles, while rs4705343, rs17796757, rs3733845, and rs3733846 were significantly associated with a decreased risk of CRC.
|
23628392 |
2013 |
|
rs41291957
|
|
Lymphoma, Non-Hodgkin
|
|
0.010 |
GeneticVariation
|
BEFREE |
We identified three SNPs in MIR143 that are to be significantly associated with reduced risk of NHL: rs3733846 (odds ratio (OR) [95% confidence interval (CI)] = 0.54 [0.33 ⁻ 0.86], p = 0.010), rs41291957 (OR [95% CI] = 0.61 [0.39 ⁻ 0.94], p = 0.024), and rs17723799 (OR [95% CI] = 0.43 [0.26 ⁻ 0.71], p = 0.0009).
|
30818878 |
2019 |
|
rs41291957
|
|
Colorectal Carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
However, the association of six polymorphisms (miR-608 rs4919510, miR-499a rs3746444, miR-146a rs2910164, pre-miR-143 rs41291957, pre-miR-124-1 rs531564 and pre-miR-26a-1 rs7372209) with colorectal cancer (CRC) risk, therapeutic response and survival remains unclear.
|
27713147 |
2016 |
|
rs41291957
|
|
Carcinogenesis
|
|
0.010 |
GeneticVariation
|
BEFREE |
The rs41291957 variant located in the pri-miR-143 sequence is associated with colorectal carcinogenesis.
|
24752771 |
2014 |
|
rs41291957
|
|
Coronary heart disease
|
|
0.010 |
GeneticVariation
|
BEFREE |
Logistic regression analyses showed no significant association of genotype or allele frequencies of pri-miR-143 rs41291957 A/G polymorphism with the CHD cases in overall or various subtypes compared with the control group.
|
24752771 |
2014 |
|
rs41291957
|
|
Congenital heart disease
|
|
0.010 |
GeneticVariation
|
BEFREE |
Therefore, the authors hypothesized that rs41291957 in pri-miR-143 might be involved in the risk of sporadic congenital heart disease (CHD).
|
24752771 |
2014 |
|
rs41291957
|
|
Neoplasms
|
|
0.010 |
GeneticVariation
|
BEFREE |
When stratification analysis was done by different variables, such as tumor size, tumor site, differentiated status, clinical stage, and metastasis status, we found that patients with the mutant allele of rs41291957 had an increased risk to develop a tumor size larger than 5 cm.
|
23628392 |
2013 |
|
rs41291957
|
|
Neoplasm Metastasis
|
|
0.010 |
GeneticVariation
|
BEFREE |
When stratification analysis was done by different variables, such as tumor size, tumor site, differentiated status, clinical stage, and metastasis status, we found that patients with the mutant allele of rs41291957 had an increased risk to develop a tumor size larger than 5 cm.
|
23628392 |
2013 |
|
rs4705342
|
|
Intracranial Aneurysm
|
|
0.010 |
GeneticVariation
|
BEFREE |
Haplotype of the two loci of rs4705342 and rs4705343 showed that the CT haplotype carried a lower IA risk and higher miR-143 level.
|
28272526 |
2017 |
|
rs4705342
|
|
Malignant neoplasm of prostate
|
|
0.010 |
GeneticVariation
|
BEFREE |
In conclusion, our findings demonstrate that there is the significant association between the functional promoter variant rs4705342T>C in miR-143 and PCa risk and newly describe the miR-143-KLK2 interaction which provided another potential mechanism for miR-143 anti-tumor function.
|
25354797 |
2016 |
|
rs4705342
|
|
Prostate carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
In conclusion, our findings demonstrate that there is the significant association between the functional promoter variant rs4705342T>C in miR-143 and PCa risk and newly describe the miR-143-KLK2 interaction which provided another potential mechanism for miR-143 anti-tumor function.
|
25354797 |
2016 |
|
rs4705343
|
|
Conotruncal defect
|
|
0.010 |
GeneticVariation
|
BEFREE |
<b>Results:</b> An association between SNP rs4705343</span> of <i>miR-143/145</i> and CTDs has been confirmed in the Chinese Han population.
|
31691635 |
2019 |
|
rs4705343
|
|
Prostate carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
Since miRNA-based mechanisms are shown to be involved in the pathogenesis of prostate cancer (PCa), the aim of the present study was to evaluate the effect of rs4938723, rs1076064 and rs4705343 occurring in regulatory regions of miR-34b/c, miR-143/145 and miR-378, respectively, on PCa risk and progression in Serbian population.
|
31423132 |
2019 |
|
rs4705343
|
|
Malignant neoplasm of prostate
|
|
0.010 |
GeneticVariation
|
BEFREE |
Since miRNA-based mechanisms are shown to be involved in the pathogenesis of prostate cancer (PCa), the aim of the present study was to evaluate the effect of rs4938723, rs1076064 and rs4705343 occurring in regulatory regions of miR-34b/c, miR-143/145 and miR-378, respectively, on PCa risk and progression in Serbian population.
|
31423132 |
2019 |
|
rs4705343
|
|
Non-Small Cell Lung Carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
Our results indicated that the A allele of rs11134527 might be a risk factor (OR=1.24; 95% CI: 1.03-1.50) and that the T allele of rs4705343 might be a protective factor (OR=0.80; 95% CI: 0.66-0.98) for NSCLC in a Han Chinese population.
|
29692628 |
2018 |
|
rs4705343
|
|
Intracranial Aneurysm
|
|
0.010 |
GeneticVariation
|
BEFREE |
Haplotype of the two loci of rs4705342 and rs4705343 showed that the CT haplotype carried a lower IA risk and higher miR-143 level.
|
28272526 |
2017 |