Source: BEFREE

Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs12128240
rs12128240
MIR34A ; MIR34AHG
CUI: C0948008
Disease: Ischemic stroke
Ischemic stroke 		0.010 GeneticVariation BEFREE However, no significant association between rs12128240 or rs6577555 and IS was found. 31068831

2019
dbSNP: rs2666433
rs2666433
MIR34A ; MIR34AHG
CUI: C0948008
Disease: Ischemic stroke
Ischemic stroke 		0.010 GeneticVariation BEFREE We found that rs2666433 was associated with a significantly increased risk of IS (AA vs. GG: OR = 1.61, 95% CI = 1.05-2.52, <i>P</i> = 0.031; AA vs. GG+GA: OR = 1.58, 95% CI = 1.05-2.45, <i>P</i> = 0.026). 31068831

2019
dbSNP: rs2666433
rs2666433
MIR34A ; MIR34AHG
CUI: C4699512
Disease: Large-artery atherosclerosis (embolus/thrombosis)
Large-artery atherosclerosis (embolus/thrombosis) 		0.010 GeneticVariation BEFREE For the IS subtypes, rs2666433 was associated with large artery atherosclerosis (AA vs. GG: OR = 2.09, 95% CI = 1.16-3.51, <i>P</i> = 0.007; AA vs. GG+GA: OR = 2.02, 95% CI = 1.15-3.33, <i>P</i> = 0.007; A vs. G: OR = 1.36, 95% CI = 1.07-1.81, <i>P</i> = 0.021). 31068831

2019
dbSNP: rs35301225
rs35301225
MIR34A ; MIR34AHG
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis 		0.010 GeneticVariation BEFREE Moreover, the SNP in rs35301225 of miR-34a was associated with tumor size and tumor differentiation, as well as metastasis in CRC patients; C/A SNP was related to the significantly enhanced expression of E2F1 and shorter survival in post-surgery CRC patients. 28293146

2017
dbSNP: rs35301225
rs35301225
MIR34A ; MIR34AHG
CUI: C0699790
Disease: Colon Carcinoma
Colon Carcinoma 		0.010 GeneticVariation BEFREE rs35301225 in miR-34a was highly associated with a decreased risk of CRC in a Chinese population and might serve as a novel biomarker for colon cancer. 28293146

2017
dbSNP: rs35301225
rs35301225
MIR34A ; MIR34AHG
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma 		0.010 GeneticVariation BEFREE rs35301225 in miR-34a was highly associated with a decreased risk of CRC in a Chinese population and might serve as a novel biomarker for colon cancer. 28293146

2017
dbSNP: rs35301225
rs35301225
MIR34A ; MIR34AHG
CUI: C0027651
Disease: Neoplasms
Neoplasms 		0.010 GeneticVariation BEFREE Moreover, the SNP in rs35301225 of miR-34a was associated with tumor size and tumor differentiation, as well as metastasis in CRC patients; C/A SNP was related to the significantly enhanced expression of E2F1 and shorter survival in post-surgery CRC patients. 28293146

2017
dbSNP: rs35301225
rs35301225
MIR34A ; MIR34AHG
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon 		0.010 GeneticVariation BEFREE rs35301225 in miR-34a was highly associated with a decreased risk of CRC in a Chinese population and might serve as a novel biomarker for colon cancer. 28293146

2017
dbSNP: rs6577555
rs6577555
MIR34A ; MIR34AHG
CUI: C0948008
Disease: Ischemic stroke
Ischemic stroke 		0.010 GeneticVariation BEFREE However, no significant association between rs12128240 or rs6577555 and IS was found. 31068831

2019
dbSNP: rs72631823
rs72631823
MIR34A ; MIR34AHG
CUI: C3539878
Disease: Triple Negative Breast Neoplasms
Triple Negative Breast Neoplasms 		0.010 GeneticVariation BEFREE Our case-control study suggests that pre-miR34a rs72631823 A allele is associated with increased triple negative breast cancer risk. 30651924

2018
dbSNP: rs72631823
rs72631823
MIR34A ; MIR34AHG
CUI: C4722518
Disease: Triple-Negative Breast Carcinoma
Triple-Negative Breast Carcinoma 		0.010 GeneticVariation BEFREE Our case-control study suggests that pre-miR34a rs72631823 A allele is associated with increased triple negative breast cancer risk. 30651924

2018