|
rs17576
|
|
Coronary Artery Disease
|
|
0.060 |
GeneticVariation
|
BEFREE |
And some studies have reported that the G allele of rs17576 might be associated with CAD.
|
23819814 |
2013 |
|
rs17576
|
|
Coronary Artery Disease
|
|
0.060 |
GeneticVariation
|
BEFREE |
This meta-analysis provided evidence that genetic polymorphism of MMP1-1607 1G/2G, MMP3-Gly45lys, MMP3-376 G/C, MMP3-1171 5A/6A, MMP9-1562 C/T and MMP9-R279Q have a small to medium effect on incidence of coronary disease.
|
22226810 |
2012 |
|
rs17576
|
|
Coronary Artery Disease
|
|
0.060 |
GeneticVariation
|
BEFREE |
The promoter -1562C/T and exon 6 R279Q A/G polymorphisms were determined in 1001 patients with angiographically verified stable CAD and in 204 healthy controls.
|
21963461 |
2012 |
|
rs17576
|
|
Coronary Artery Disease
|
|
0.060 |
GeneticVariation
|
BEFREE |
We explored the association of MMP2 (C-735T, rs2285053), MMP7 (A-181G, rs11568818) and MMP9 (R279Q, rs17576), (P574R, rs2250889), (R668Q, rs17577) genetic variants with LVD in coronary artery disease (CAD) patients.
|
22664146 |
2012 |
|
rs17576
|
|
Coronary Artery Disease
|
|
0.060 |
GeneticVariation
|
BEFREE |
These findings suggest that MMP-9 R279Q, P574R and R668Q may have combined effect in the occurrence of CAD and -1562 CT/TT genotypes may contribute to CAD in diabetics and MI in CAD patients.
|
19283512 |
2010 |
|
rs17576
|
|
Coronary Artery Disease
|
|
0.060 |
GeneticVariation
|
BEFREE |
The aim of this study was to analyze the occurrence of the -1612 5A/6A, -376C/G, and Glu45Lys polymorphisms of MMP3 and the -1562C/T and R279Q polymorphisms of MMP9 and their relation to the risk of coronary heart disease (CHD; stenosis >/=50% of the diameter in at least one major coronary artery) in a Chinese Han population.
|
19438845 |
2009 |
|
rs3918242
|
|
Ischemic stroke
|
|
0.060 |
GeneticVariation
|
BEFREE |
The rs3918242 polymorphism may be a susceptible predictor of susceptibility of IS.
|
31415895 |
2020 |
|
rs3918242
|
|
Ischemic stroke
|
|
0.060 |
GeneticVariation
|
BEFREE |
Subgroup analysis by the type of stroke showed that MMP-9 gene rs3918242 polymorphism increased the risk of ischemic stroke.
|
30132967 |
2018 |
|
rs3918242
|
|
Coronary Artery Disease
|
|
0.060 |
GeneticVariation
|
BEFREE |
A statistically significant association between rs3918242 polymorphism and CAD was observed in allelic model (Odds ratio (OR) 1.34; 95% confidence interval (CI) 1.20-1.50; <i>p</i> < 0.00001), recessive model (OR 1.43; 95% CI 1.17-1.75; <i>p</i> = 0.0004), and in dominant model ( OR 1.36; 95% CI 1.20-1.53; <i>p</i> < 0.00001).
|
29507703 |
2018 |
|
rs3918242
|
|
Ischemic stroke
|
|
0.060 |
GeneticVariation
|
BEFREE |
Our study provides preliminary evidence that the MMP9 rs3918242 polymorphism is linked to a higher risk of IS, confirming the role of MMP9 in the pathophysiology of IS, with potentially important therapeutic implications.
|
30257242 |
2018 |
|
rs3918242
|
|
Ischemic stroke
|
|
0.060 |
GeneticVariation
|
BEFREE |
Therefore, our meta-analysis suggested that MMP-9 rs3918242 variants (T allele, TT and CT genotypes) contributed to significantly increase the risk of IS in the Chinese population.
|
28258806 |
2017 |
|
rs3918242
|
|
Coronary Artery Disease
|
|
0.060 |
GeneticVariation
|
BEFREE |
Matrix metalloproteinase 9 (MMP9) -1562C>T (rs3918242) polymorphism has been proposed as a risk factor for coronary artery disease (CAD) with conflicting results.
|
28400830 |
2017 |
|
rs3918242
|
|
Coronary Artery Disease
|
|
0.060 |
GeneticVariation
|
BEFREE |
Impact of matrix metalloproteinase 9 rs3918242 genetic variant on lipid-lowering efficacy of simvastatin therapy in Chinese patients with coronary heart disease.
|
28390432 |
2017 |
|
rs3918242
|
|
Ischemic stroke
|
|
0.060 |
GeneticVariation
|
BEFREE |
The findings of this study suggest that the MMP9 rs3918242 polymorphism is associated with an elevated risk of ische</span>mic stroke and that this gene polymorphism interacts with BMI in the risk of ischemic stroke.
|
26782596 |
2016 |
|
rs3918242
|
|
Coronary Artery Disease
|
|
0.060 |
GeneticVariation
|
BEFREE |
We observed that the T allele of rs3918242 was correlated with increased risk of coron</span>ary artery disease (OR = 1.88, 95%CI = 1.39-2.55).
|
27323016 |
2016 |
|
rs3918242
|
|
Ischemic stroke
|
|
0.060 |
GeneticVariation
|
BEFREE |
The TC+CC genotype of MMP9 rs3918242 was associated with an elevated risk of ischemic stroke in tobacco smokers, and the OR (95% CI) was 2.03 (1.11-3.74).
|
26617904 |
2015 |
|
rs3918242
|
|
Coronary Artery Disease
|
|
0.060 |
GeneticVariation
|
BEFREE |
This study was aimed to investigate the prognostic significance of the IL-18+183 A/G polymorphism (rs5744292), single and in coexistence with the matrix metalloproteinase (MMP)-9 -1562 C/T (rs3918242) polymorphism, in patients with stable coronary artery disease (CAD).
|
24040261 |
2013 |
|
rs3918242
|
|
Coronary Artery Disease
|
|
0.060 |
GeneticVariation
|
BEFREE |
Our results suggest that the single-nucleotide polymorphism of rs3918242 in the MMP-9 gene is associated with CAD and high serum levels of MMP-9 are also associated with CAD in the Chinese Han population.
|
23819814 |
2013 |
|
rs17576
|
|
Primary angle-closure glaucoma
|
|
0.050 |
GeneticVariation
|
BEFREE |
Interestingly, distribution of rs17576 variant was statistically higher in both PACG and POAG cases than healthy controls.
|
31713905 |
2020 |
|
rs17576
|
|
Angle Closure Glaucoma
|
|
0.050 |
GeneticVariation
|
BEFREE |
Interestingly, distribution of rs17576 variant was statistically higher in both PACG and POAG cases than healthy controls.
|
31713905 |
2020 |
|
rs17576
|
|
Primary angle-closure glaucoma
|
|
0.050 |
GeneticVariation
|
BEFREE |
Significant heterogeneity between non-Chinese and Chinese datasets precluded overall meta-analysis for rs17576 and rs3918249 (Q = 0.001 and 0.04 respectively). rs17577 was nominally associated with PACG in one Caucasian study (OR = 1.71, P = 0.02), but not in 3 Chinese studies including our study (ORs = 1.20, P = 0.07).
|
27272641 |
2016 |
|
rs17576
|
|
Angle Closure Glaucoma
|
|
0.050 |
GeneticVariation
|
BEFREE |
Significant heterogeneity between non-Chinese and Chinese datasets precluded overall meta-analysis for rs17576 and rs3918249 (Q = 0.001 and 0.04 respectively). rs17577 was nominally associated with PACG in one Caucasian study (OR = 1.71, P = 0.02), but not in 3 Chinese studies including our study (ORs = 1.20, P = 0.07).
|
27272641 |
2016 |
|
rs17576
|
|
Angle Closure Glaucoma
|
|
0.050 |
GeneticVariation
|
BEFREE |
Our data suggest that the MMP1 rs1799750 (-1607 1G/2G) and MMP9 rs17576 polymorphisms might be of value for further study as potential gender-dependent risk factors for developing POAG and PACG, respectively, in Pakistan.
|
23441116 |
2013 |
|
rs17576
|
|
Primary angle-closure glaucoma
|
|
0.050 |
GeneticVariation
|
BEFREE |
Our data suggest that the MMP1 rs1799750 (-1607 1G/2G) and MMP9 rs17576 polymorphisms might be of value for further study as potential gender-dependent risk factors for developing POAG and PACG, respectively, in Pakistan.
|
23441116 |
2013 |
|
rs17576
|
|
Primary angle-closure glaucoma
|
|
0.050 |
GeneticVariation
|
BEFREE |
This study demonstrates an association between MMP9 SNPs rs3918249 and rs17576 and PACG in the Australian population, suggesting MMP9 may be involved in the pathogenesis of this blinding disease.
|
21655354 |
2011 |