|
rs117856857
|
|
gallbladder neoplasm
|
|
0.010 |
GeneticVariation
|
BEFREE |
The G allele at rs117856857 was associated with the presence of gallbladder tumors (p = 0.019) and with MYC expression (p = 0.044).
|
25200035 |
2015 |
|
rs2070583
|
|
Coronary heart disease
|
|
0.010 |
GeneticVariation
|
BEFREE |
We also identified a SNP achieving array wide significance (MYC: rs2070583, allele frequency 0.02, P = 8.1 × 10(-8)), but the association did not replicate in an additional 8,059 African Americans (577 events) from the WHI, HealthABC and GeneSTAR studies, and in a meta-analysis of 5 cohort studies of European ancestry (24,024 individuals including 1,570 cases of MI and 2,406 cases of CHD) from the CHARGE Consortium.
|
25542012 |
2014 |
|
rs2071346
|
|
Thrombocytopenia
|
|
0.010 |
GeneticVariation
|
BEFREE |
We also found rs2071346 (G>T) variant genotype carriers were subjected to higher risk of anemia (GT <i>vs</i> GG, OR=1.665, P=0.022) and thrombocytopenia (GT <i>vs</i> GG, OR=1.685, P=0.035).
|
30662535 |
2019 |
|
rs2071346
|
|
Anemia
|
|
0.010 |
GeneticVariation
|
BEFREE |
We also found rs2071346 (G>T) variant genotype carriers were subjected to higher risk of anemia (GT <i>vs</i> GG, OR=1.665, P=0.022) and thrombocytopenia (GT <i>vs</i> GG, OR=1.685, P=0.035).
|
30662535 |
2019 |
|
rs2071346
|
|
Nasopharyngeal carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
We found two SNPs rs4645948 (C>T) and rs2071346 (G>T) were significantly associated with increased risk of developing NPC (TT+CT <i>vs</i> CC, OR=1.557, P=3.34×10<sup>-4</sup>; TT+GT <i>vs</i> GG, OR=1.361, P=0.007, respectively).
|
30662535 |
2019 |
|
rs28933407
|
|
Neoplasms
|
|
0.010 |
GeneticVariation
|
BEFREE |
Moreover, two tumors presented a pathogenic mutation in MYC exon 2 (rs28933407).
|
25200035 |
2015 |
|
rs3824120
|
|
Malignant Neoplasms
|
|
0.010 |
GeneticVariation
|
BEFREE |
We determined that one SNP allele (rs3824120) in a CpG island associated with MYC which eliminated a CpG was more common in the cancer datasets than in the 100Genomes databases (p < 0.01).
|
27074591 |
2016 |
|
rs3824120
|
|
Primary malignant neoplasm
|
|
0.010 |
GeneticVariation
|
BEFREE |
We determined that one SNP allele (rs3824120) in a CpG island associated with MYC which eliminated a CpG was more common in the cancer datasets than in the 100Genomes databases (p < 0.01).
|
27074591 |
2016 |
|
rs4645948
|
|
Anemia
|
|
0.010 |
GeneticVariation
|
BEFREE |
In addition, rs4645948 (C>T) was conferred with increased risk of anemia (CT <i>vs</i> CC, OR=2.152, P=0.001) and severe leukopenia (CT <i>vs</i> CC, OR=1.893, P=0.034) for NPC patients receiving chemoradiotherapy.
|
30662535 |
2019 |
|
rs4645948
|
|
Leukopenia
|
|
0.010 |
GeneticVariation
|
BEFREE |
In addition, rs4645948 (C>T) was conferred with increased risk of anemia (CT <i>vs</i> CC, OR=2.152, P=0.001) and severe leukopenia (CT <i>vs</i> CC, OR=1.893, P=0.034) for NPC patients receiving chemoradiotherapy.
|
30662535 |
2019 |
|
rs4645948
|
|
Nasopharyngeal carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
These findings suggested that individual carrying the rs4645948 T allele may be at greater risk for NPC due to an increase of MYC transcriptional activity and an augment of MYC expression.
|
30662535 |
2019 |
|
rs4645959
|
|
Breast Carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
A joint analysis of the Polish and the German study population revealed a 54% increased risk for breast cancer associated with the heterozygous Asn11Ser variant (OR = 1.54, 95% CI 1.05-2.26, p = 0.028).
|
15929079 |
2005 |
|
rs4645959
|
|
Malignant neoplasm of breast
|
|
0.010 |
GeneticVariation
|
BEFREE |
A joint analysis of the Polish and the German study population revealed a 54% increased risk for breast cancer associated with the heterozygous Asn11Ser variant (OR = 1.54, 95% CI 1.05-2.26, p = 0.028).
|
15929079 |
2005 |
|
rs4645959
|
|
Breast Cancer, Familial
|
|
0.010 |
GeneticVariation
|
BEFREE |
Here, we analysed the influence of the rare c-MYC Asn11Ser polymorphism on familial breast cancer risk by performing a case-control study with a Polish (cases n = 349; controls n = 441) and a German (cases n = 356; controls n = 655) study population.
|
15929079 |
2005 |
|
rs747141352
|
|
Burkitt Lymphoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
Among the 78 BLs in this series, an additional five had RHOA mutations resulting in a total incidence of 7/82 (8.5%) with c.14G>A (p.R5Q) being present in three cases.
|
25044415 |
2014 |
|
rs747141352
|
|
Adult Burkitt Lymphoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
Among the 78 BLs in this series, an additional five had RHOA mutations resulting in a total incidence of 7/82 (8.5%) with c.14G>A (p.R5Q) being present in three cases.
|
25044415 |
2014 |
|
rs747141352
|
|
Childhood Burkitt Lymphoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
Among the 78 BLs in this series, an additional five had RHOA mutations resulting in a total incidence of 7/82 (8.5%) with c.14G>A (p.R5Q) being present in three cases.
|
25044415 |
2014 |