|
rs4795067
|
|
Psoriasis
|
|
0.820 |
GeneticVariation
|
BEFREE |
Additionally, we found genome-wide significant association to the previously reported psoriasis risk loci; NOS2 (rs4795067, p=5.27×10(-9)).
|
25923216 |
2015 |
|
rs4795067
|
|
Psoriasis
|
|
0.820 |
GeneticVariation
|
BEFREE |
Recently, genome-wide association studies identified a novel psoriasis susceptibility locus tagged by two single-nucleotide polymorphisms (SNPs) rs4795067 and rs28998802, both of which are in the intronic region of inducible nitric oxide synthase (iNOS) gene.
|
25663087 |
2015 |
|
rs28998802
|
|
Psoriasis
|
|
0.810 |
GeneticVariation
|
BEFREE |
Recently, genome-wide association studies identified a novel psoriasis susceptibility locus tagged by two single-nucleotide polymorphisms (SNPs) rs4795067 and rs28998802, both of which are in the intronic region of inducible nitric oxide synthase (iNOS) gene.
|
25663087 |
2015 |
|
rs1060826
|
|
Parkinson Disease
|
|
0.030 |
GeneticVariation
|
BEFREE |
In comparing PD in homozygous variant carriers of NOS2A rs1060826 versus homozygous wild-type or heterozygotes, we estimate an adjusted odds ratio (OR) of 1.51 (95% CI: 0.95, 2.41).
|
26383258 |
2016 |
|
rs1060826
|
|
Parkinson Disease
|
|
0.030 |
GeneticVariation
|
BEFREE |
Two previous studies reported an association of a single nucleotide polymorphism (rs1060826) with PD.
|
17159127 |
2006 |
|
rs1060826
|
|
Parkinson Disease
|
|
0.030 |
GeneticVariation
|
BEFREE |
Among the pooled earliest onset families, rs2255929 and rs1060826 generated significant allelic (p = 0.000059 and 0.0062, respectively) and genotypic (p = 0.0039 and 0.0014, respectively) associations with risk and AAO (p = 0.00070 and 0.0073, respectively); the two-SNP haplotype generated even stronger association with PD (p = 0.000013).
|
16823855 |
2006 |
|
rs1137933
|
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.020 |
GeneticVariation
|
BEFREE |
CT genotype of rs1137933C/T was significantly associated with increased risk of T2D (<i>P</i><0.0001).
|
30581791 |
2018 |
|
rs1137933
|
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.020 |
GeneticVariation
|
BEFREE |
CT genotype and C allele of NOS2 rs1137933 C/T polymorphism were associated with a higher risk of T2D, and no association was observed between T allele of NOS2 rs2779248 T/C polymorphism and T2D while TC genotype of this SNP decreased the risk of T2D in the study participants.
|
30581791 |
2018 |
|
rs1137933
|
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.020 |
GeneticVariation
|
BEFREE |
These preliminary findings indicate that the NOS2 rs2779248, NOS2 rs1137933, and NOS3 rs3918188 genetic polymorphisms are potentially related to the susceptibility to T2DM, and the rs1800783 polymorphism might be considered as genetic risk factors for diabetic nephropathy, and family history of diabetes was closely associated with rs11771443 polymorphism in DN, and the genetic variants might be used as molecular markers for evaluating the risk of T2DM and diabetic nephropathy.© 2016 IUBMB Life, 68(7):516-525, 2016.
|
27192959 |
2016 |
|
rs2255929
|
|
Parkinson Disease
|
|
0.020 |
GeneticVariation
|
BEFREE |
Significant associations with PD were detected for the NOS1 SNPs rs3782218, rs11068447, rs7295972, rs2293052, rs12829185, rs1047735, rs3741475, and rs2682826 (range of p = 0.00083-0.046) and the NOS2A SNPs rs2072324, rs944725, rs12944039, rs2248814, rs2297516, rs1060826, and rs2255929 (range of p = 0.0000040-0.047) in earlier-onset families with sporadic PD, and some SNPs were also associated with earlier AAO.
|
18663495 |
2008 |
|
rs2255929
|
|
Parkinson Disease
|
|
0.020 |
GeneticVariation
|
BEFREE |
Among the pooled earliest onset families, rs2255929 and rs1060826 generated significant allelic (p = 0.000059 and 0.0062, respectively) and genotypic (p = 0.0039 and 0.0014, respectively) associations with risk and AAO (p = 0.00070 and 0.0073, respectively); the two-SNP haplotype generated even stronger association with PD (p = 0.000013).
|
16823855 |
2006 |
|
rs2297518
|
|
Malignant neoplasm of stomach
|
|
0.020 |
GeneticVariation
|
BEFREE |
<i>iNOS</i> rs2297518 and <i>eNOS</i> rs2070744 polymorphisms may represent susceptible factors for gastric cancer.
|
29765229 |
2018 |
|
rs2297518
|
|
Stomach Carcinoma
|
|
0.020 |
GeneticVariation
|
BEFREE |
<i>iNOS</i> rs2297518 and <i>eNOS</i> rs2070744 polymorphisms may represent susceptible factors for gastric cancer.
|
29765229 |
2018 |
|
rs2297518
|
|
Carcinogenesis
|
|
0.020 |
GeneticVariation
|
BEFREE |
The roles of interleukin 8 (<i>IL8</i>) rs4073, nuclear factor kappa B (<i>NF</i>κ<i>B</i>) rs28362491, cytochrome b-245, alpha polypeptide (<i>CYBA</i>) rs4673, <i>NAD(P) H</i> dehydrogenase, quinone 1 (<i>NQO1</i>) rs1800566, nitric oxide synthase 2 and inducible (<i>NOS2</i>) rs2297518 polymorphisms in lung carcinogenesis were investigated.
|
28529598 |
2017 |
|
rs2297518
|
|
Malignant Neoplasms
|
|
0.020 |
GeneticVariation
|
BEFREE |
The results indicated that the polymorphisms in iNOS gene (C150T(Ser(608) Leu) polymorphism and polymorphic (CCTTT)n repeats) had no association with cancer risk for all genetic models.
|
26391304 |
2015 |
|
rs2297518
|
|
Primary malignant neoplasm
|
|
0.020 |
GeneticVariation
|
BEFREE |
The results indicated that the polymorphisms in iNOS gene (C150T(Ser(608) Leu) polymorphism and polymorphic (CCTTT)n repeats) had no association with cancer risk for all genetic models.
|
26391304 |
2015 |
|
rs2297518
|
|
Carcinogenesis
|
|
0.020 |
GeneticVariation
|
BEFREE |
However, the NOS2 Ser608Leu polymorphism was not associated with gastric carcinogenesis.
|
20565800 |
2010 |
|
rs2297518
|
|
Malignant Neoplasms
|
|
0.020 |
GeneticVariation
|
BEFREE |
The aim of this study was to evaluate the association of NOS2 polymorphisms Ser608Leu (rs2297518) in exon 16, -954G/C and -1173C/T, both in the promoter region, with gastric cancer and chronic gastritis and the association of cancer with risk factors such as smoking, alcohol intake and H. pylori infection.
|
20565800 |
2010 |
|
rs2297518
|
|
Stomach Carcinoma
|
|
0.020 |
GeneticVariation
|
BEFREE |
SNP Ser608Leu was not associated with risk of chronic gastritis or gastric cancer.
|
20565800 |
2010 |
|
rs2297518
|
|
Malignant neoplasm of stomach
|
|
0.020 |
GeneticVariation
|
BEFREE |
SNP Ser608Leu was not associated with risk of chronic gastritis or gastric cancer.
|
20565800 |
2010 |
|
rs2297518
|
|
Primary malignant neoplasm
|
|
0.020 |
GeneticVariation
|
BEFREE |
The aim of this study was to evaluate the association of NOS2 polymorphisms Ser608Leu (rs2297518) in exon 16, -954G/C and -1173C/T, both in the promoter region, with gastric cancer and chronic gastritis and the association of cancer with risk factors such as smoking, alcohol intake and H. pylori infection.
|
20565800 |
2010 |
|
rs2779248
|
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.020 |
GeneticVariation
|
BEFREE |
CT genotype and C allele of NOS2 rs1137933 C/T polymorphism were associated with a higher risk of T2D, and no association was observed between T allele of NOS2 rs2779248 T/C polymorphism and T2D while TC genotype of this SNP decreased the risk of T2D in the study participants.
|
30581791 |
2018 |
|
rs2779248
|
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.020 |
GeneticVariation
|
BEFREE |
Nitric Oxide Synthase 2 Polymorphisms (rs2779248T/C and rs1137933C/T) and the Risk of Type 2 Diabetes in Zahedan, Southeastern Iran.
|
30581791 |
2018 |
|
rs2779248
|
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.020 |
GeneticVariation
|
BEFREE |
These preliminary findings indicate that the NOS2 rs2779248, NOS2 rs1137933, and NOS3 rs3918188 genetic polymorphisms are potentially related to the susceptibility to T2DM, and the rs1800783 polymorphism might be considered as genetic risk factors for diabetic nephropathy, and family history of diabetes was closely associated with rs11771443 polymorphism in DN, and the genetic variants might be used as molecular markers for evaluating the risk of T2DM and diabetic nephropathy.© 2016 IUBMB Life, 68(7):516-525, 2016.
|
27192959 |
2016 |
|
rs2779249
|
|
Disorder of Achilles tendon
|
|
0.020 |
GeneticVariation
|
BEFREE |
The rs2779249 CA genotype within the human iNOS gene appears to protect individuals from Achilles tendinopathy.
|
31761559 |
2020 |