rs111874856
|
|
Behcet Syndrome
|
|
0.010 |
GeneticVariation
|
BEFREE |
In the presence of CC genotype for rs73963110, CT genotype for rs111874856 (Val355Ile), and TC genotype for rs112130712 (Lys1054Arg) polymorphisms, the risk of BD increased 12.13-, 15.05-, and 16.28-fold, respectively (p < 0.0001).
|
24566943 |
2014 |
rs112108028
|
|
Behcet Syndrome
|
|
0.010 |
GeneticVariation
|
BEFREE |
There was a lower frequency of the GA genotype of the rs112108028 (Pro1164Leu) polymorphisms in BD (10.3 %) compared with controls (39.7 %; p < 0.0001).
|
24566943 |
2014 |
rs112130712
|
|
Behcet Syndrome
|
|
0.010 |
GeneticVariation
|
BEFREE |
In the presence of CC genotype for rs73963110, CT genotype for rs111874856 (Val355Ile), and TC genotype for rs112130712 (Lys1054Arg) polymorphisms, the risk of BD increased 12.13-, 15.05-, and 16.28-fold, respectively (p < 0.0001).
|
24566943 |
2014 |
rs1481280
|
|
Hypertensive disease
|
|
0.010 |
GeneticVariation
|
BEFREE |
The follow-up analysis showed that rs1481280 of ROCK1 significantly associated with incident hypertension (HR=1.130, P=0.048) after adjusting for covariates. rs7589629 and rs978906 of ROCK2 were significantly associated with incident IS (HR=1.373, P=0.004; HR=1.284, P=0.026) respectively.
|
29246448 |
2018 |
rs1481280
|
|
Ischemic stroke
|
|
0.010 |
GeneticVariation
|
BEFREE |
In stroke case-control study, rs288980, rs14</span>81280 and rs7237677 were significantly associated with IS and the adjusted ORs (P values) of additive model were 0.879 (0.010), 0.895 (0.036) and 0.857 (0.002) respectively.
|
29246448 |
2018 |
rs2271255
|
|
Respiratory Distress Syndrome, Newborn
|
|
0.010 |
GeneticVariation
|
BEFREE |
We observed that ROCK1 gene rs2271255 (Lys222Glu) and rs35996865 polymorphisms, and ROCK2 gene rs726843, rs2290156, rs10178332, and rs35768389 (Asp601Val) polymorphisms were associated with RDS.
|
27269648 |
2017 |
rs288979
|
|
Tetralogy of Fallot
|
|
0.010 |
GeneticVariation
|
BEFREE |
The minor allele frequency of rs288979 in the controls was 0.043, and the variant accounted for 11% of the PAR of TOF.
|
23782575 |
2013 |
rs288980
|
|
Ischemic stroke
|
|
0.010 |
GeneticVariation
|
BEFREE |
In stroke case-control study, rs288980, rs1481280 and rs7237677 were significantly associated with IS and the adjusted ORs (P values) of additive model were 0.879 (0.010), 0.895 (0.036) and 0.857 (0.002) respectively.
|
29246448 |
2018 |
rs35996865
|
|
Respiratory Distress Syndrome, Newborn
|
|
0.010 |
GeneticVariation
|
BEFREE |
We observed that ROCK1 gene rs2271255 (Lys222Glu) and rs35996865 polymorphisms, and ROCK2 gene rs726843, rs2290156, rs10178332, and rs35768389 (Asp601Val) polymorphisms were associated with RDS.
|
27269648 |
2017 |
rs35996865
|
|
Systemic Scleroderma
|
|
0.010 |
GeneticVariation
|
BEFREE |
Significant association was found in a polymorphism in the ROCK1 gene (rs35996865), a polymorphism in ROCK2 gene (rs10178332), a polymorphism in RhoA gene (rs2177268) and two polymorphisms in RhoC gene (rs11102522 and rs11538960) with SSc disease (p < 0.0022).
|
26615410 |
2016 |
rs35996865
|
|
Conventional (Clear Cell) Renal Cell Carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
Our results indicate that the two SNPs (Cav-1 rs1049334 and ROCK1 rs35996865) and genotypes with a combination of 2-4 risk alleles were associated with the risk of ccRCC.
|
26066055 |
2015 |
rs35996865
|
|
Colorectal Carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
There were significant associations between ROCK1 (rs73963110 and rs35996865) and ROCK2 gene polymorphisms (rs2290156, rs10178332, rs35768389, rs10929732 and rs34945852) with CRC development.
|
23328676 |
2013 |
rs531292167
|
|
Respiratory Distress Syndrome, Newborn
|
|
0.010 |
GeneticVariation
|
BEFREE |
We observed that ROCK1 gene rs2271255 (Lys222Glu) and rs35996865 polymorphisms, and ROCK2 gene rs726843, rs2290156, rs10178332, and rs35768389 (Asp601Val) polymorphisms were associated with RDS.
|
27269648 |
2017 |
rs56085230
|
|
Tetralogy of Fallot
|
|
0.010 |
GeneticVariation
|
BEFREE |
Association between genotypes and TOF was assessed using LAMP.A rare SNP (c.807C > T; rs56085230) discovered by sequencing was associated with TOF risk (p = 0.006) in the discovery cohort.
|
23782575 |
2013 |
rs7237677
|
|
Ischemic stroke
|
|
0.010 |
GeneticVariation
|
BEFREE |
In stroke case-control study, rs288980, rs1481280 and rs7237677 were significantly associated with IS and the adjusted ORs (P values) of additive model were 0.879 (0.010), 0.895 (0.036) and 0.857 (0.002) respectively.
|
29246448 |
2018 |
rs73963110
|
|
Colorectal Carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
There were significant associations between ROCK1 (rs73963110 and rs35996865) and ROCK2 gene polymorphisms (rs2290156, rs10178332, rs35768389, rs10929732 and rs34945852) with CRC development.
|
23328676 |
2013 |