|
rs2010963
|
|
Coronary Artery Disease
|
|
0.060 |
GeneticVariation
|
BEFREE |
In summary, we concluded that the VEGF gene polymorphisms rs699947, rs2010963, and rs3025039 are correlated with an elevated CAD risk.
|
29973139 |
2018 |
|
rs2010963
|
|
Coronary Artery Disease
|
|
0.060 |
GeneticVariation
|
BEFREE |
Vascular endothelial growth factor rs20</span>10963 polymorphism may be associated with the presence of CAD and its long-term survival, but not with its severity.
|
27704620 |
2017 |
|
rs2010963
|
|
Coronary Artery Disease
|
|
0.060 |
GeneticVariation
|
BEFREE |
Our results indicated that ACE(rs4646994)-D allele alone and in the presence of VEGF(rs2010963)-G allele can be an important independent risk factor for susceptibility of CAD in T2DM patients even after correcting for conventional risk factors in a population of Iran.
|
24505095 |
2015 |
|
rs2010963
|
|
Coronary Artery Disease
|
|
0.060 |
GeneticVariation
|
BEFREE |
Logistic regression analyses revealed that the VEGFA rs699947 C/A, VEGFA rs2010963 G/C, and VEGFA rs3025039 C/T polymorphisms were not associated with a risk of CAD.
|
23880405 |
2013 |
|
rs2010963
|
|
Coronary Artery Disease
|
|
0.060 |
GeneticVariation
|
BEFREE |
The possible association of rs699947 and rs2010963 with CAD risks warrant confirmation in independent case-control studies and may be informative for future investigations on the pathogenesis of CAD.
|
23545315 |
2013 |
|
rs2010963
|
|
Coronary Artery Disease
|
|
0.060 |
GeneticVariation
|
BEFREE |
This study tested the association between functional VEGF +405 C>G (rs2010963), -2578C>A (rs699947) polymorphisms, and coronary collaterals in patients with coronary artery disease (CAD).
|
20621071 |
2010 |
|
rs699947
|
|
Diabetic Retinopathy
|
|
0.060 |
GeneticVariation
|
BEFREE |
The VEGF gene SNPs analyzed with regard to DR susceptibility were rs2010963 (G > C), rs833061 (T > C), rs699947 (C > A), rs3025039 (C > T) and rs1570360 (G > A).
|
27613596 |
2017 |
|
rs699947
|
|
Diabetic Retinopathy
|
|
0.060 |
GeneticVariation
|
BEFREE |
After adjustment for covariates, significant association of DR remained with the homozygous genotype of the minor allele for the SNPs rs699947 (odds ratio [OR] = 3.54, 95% confidence interval [CI]: 1.12-11.19), rs833061 (OR = 3.72, 95% CI: 1.17-11.85), rs13207351 (OR = 3.76, 95% CI: 1.21-11.71), and rs2146323 (OR = 2.8, 95% CI: 1.46-5.37) in the VEGF gene as well as the SNP rs2071559 (OR = 1.62, 95% CI: 1.08-2.41) in the KDR gene.
|
24623964 |
2014 |
|
rs699947
|
|
Diabetic Retinopathy
|
|
0.060 |
GeneticVariation
|
BEFREE |
No evidence of association was observed between -2578 A/C (rs699947), +405C/G (rs2010963), +936C/T (rs3025039), and DR risk under stringent Bonferroni's correction.
|
24534217 |
2014 |
|
rs699947
|
|
Diabetic Retinopathy
|
|
0.060 |
GeneticVariation
|
BEFREE |
Our meta-analysis confirmed the significant association between rs699947 polymorphism and DR after exclusion of outliers, and rs2010963 polymorphism might be not associated with DR.
|
24131746 |
2013 |
|
rs699947
|
|
Diabetic Retinopathy
|
|
0.060 |
GeneticVariation
|
BEFREE |
After adjusting for covariates, a significant association of DR was observed with the homozygous genotype of the minor allele for promoter SNPs rs699947 (odds ratio (OR)=3.54, 95% confidence interval (CI): 1.12-11.19), rs833061 (OR=3.72, 95% CI: 1.17-11.85) and rs13207351 (OR=3.76, 95% CI: 1.21-11.71).
|
22162628 |
2011 |
|
rs699947
|
|
Diabetic Retinopathy
|
|
0.060 |
GeneticVariation
|
BEFREE |
We found a significant association between the A allele at rs699947 with DR (odds ratio = 1.84 (95% confidence interval = 1.28-2.66); P = 0.001 vs. noDR).
|
20444917 |
2010 |
|
rs833061
|
|
Age related macular degeneration
|
|
0.060 |
GeneticVariation
|
BEFREE |
However, weak correlations between 10 SNPs (CFH rs1329428 TT genotype, CFH rs3753394 CC genotype and T allele, CFH rs1410996 AA genotype, CFH rs800292 AA genotype, CFH rs800292 A allele, VEGF rs833061 TT genotype and C allele, VEGF rs2010963 CG genotype, VEGFR2 rs1531289 TT genotype, ARMS2 rs10490924 TT genotype, KCTD10 rs238104 GC genotype, rs1531289 T allele and ARMS2 rs10490924 T allele) and AMD were shown.
|
30696427 |
2019 |
|
rs833061
|
|
Age related macular degeneration
|
|
0.060 |
GeneticVariation
|
BEFREE |
Significant associations with AMD risk were showed for rs833061, rs1413711, and rs3025039 polymorphisms but not for rs2010963.
|
27999450 |
2016 |
|
rs833061
|
|
Age related macular degeneration
|
|
0.060 |
GeneticVariation
|
BEFREE |
The meta-analysis results based on nine case-control studies with 2427 cases and 2037 controls showed that rs833061 had protective effects on AMD risk (TT vs. CT+CC: OR=0.58, 95% CI=0.41-0.81), whereas rs1413711 (TT vs. CT+CC: OR=1.46, 95% CI=1.10-1.93) and rs3025039 (TT vs. CC: OR=1.87, 95% CI=1.15-3.02; TT vs. CT+CC: OR=2.09, 95% CI=1.30-3.37) represented as risk factors for AMD.
|
24689893 |
2014 |
|
rs833061
|
|
Age related macular degeneration
|
|
0.060 |
GeneticVariation
|
BEFREE |
Our study shows that VEGFA rs699947 and rs833061 and VEGFR2 rs2071559 polymorphisms do not modify the risk of suffering AMD in a Spanish population.
|
23971975 |
2013 |
|
rs833061
|
|
Age related macular degeneration
|
|
0.060 |
GeneticVariation
|
BEFREE |
The results suggest the VEGF-A rs1413711 and rs833061 polymorphisms may contribute to AMD susceptibility.
|
23761723 |
2013 |
|
rs833061
|
|
Age related macular degeneration
|
|
0.060 |
GeneticVariation
|
BEFREE |
In our work, we searched for an association between the -460C> (rs833061) and -634G>C (rs2010963) polymorphisms of the VEGF gene and the occurrence of AMD and its dry and wet forms.
|
19761764 |
2009 |
|
rs2010963
|
|
Age related macular degeneration
|
|
0.050 |
GeneticVariation
|
BEFREE |
However, weak correlations between 10 SNPs (CFH rs1329428 TT genotype, CFH rs3753394 CC genotype and T allele, CFH rs1410996 AA genotype, CFH rs800292 AA genotype, CFH rs800292 A allele, VEGF rs833061 TT genotype and C allele, VEGF rs2010963 CG genotype, VEGFR2 rs1531289 TT genotype, ARMS2 rs10490924 TT genotype, KCTD10 rs238104 GC genotype, rs1531289 T allele and ARMS2 rs10490924 T allele) and AMD were shown.
|
30696427 |
2019 |
|
rs2010963
|
|
Age related macular degeneration
|
|
0.050 |
GeneticVariation
|
BEFREE |
The aim of the present study is to carry out a systematic review and an updated meta-analysis in order to summarize the current published studies and to evaluate the associations between four common vascular endothelial growth factor (<i>VEGF</i>) polymorphisms (rs833061, rs1413711, rs3025039, and rs2010963) and AMD risk, also stratifying for AMD subtypes and ethnicity.
|
27999450 |
2016 |
|
rs2010963
|
|
Age related macular degeneration
|
|
0.050 |
GeneticVariation
|
BEFREE |
No association was observed between AMD risk and the variant genotypes of VEGF-A rs2010963 and rs3025039 polymorphisms in different genetic models.
|
23761723 |
2013 |
|
rs2010963
|
|
Age related macular degeneration
|
|
0.050 |
GeneticVariation
|
BEFREE |
The present meta-analyses indicated that there were no significantly associations between VEGF polymorphisms (rs833061, rs1413711, rs2010963) and the risk of AMD, although the association was different for each polymorphism among different populations.
|
22307787 |
2012 |
|
rs2010963
|
|
Age related macular degeneration
|
|
0.050 |
GeneticVariation
|
BEFREE |
In our work, we searched for an association between the -460C> (rs833061) and -634G>C (rs2010963) polymorphisms of the VEGF gene and the occurrence of AMD and its dry and wet forms.
|
19761764 |
2009 |
|
rs699947
|
|
Coronary heart disease
|
|
0.050 |
GeneticVariation
|
BEFREE |
Our overall and subgroup analyses suggested that rs699947 polymorphism was significantly associated with CHD susceptibility in both Caucasians and Asians, rs1570360 polymorphism was significantly associated with CHD susceptibility in Caucasians, and rs3025039 polymorphism was significantly associated with CHD susceptibility in Asians.
|
30317903 |
2018 |
|
rs699947
|
|
Coronary Artery Disease
|
|
0.050 |
GeneticVariation
|
BEFREE |
In addition, stratification by control source indicated an increased risk of CAD susceptibility with the rs699947 polymorphism for population-based studies of reduced heterogeneity.
|
29973139 |
2018 |