rs17824933
|
|
Multiple Sclerosis
|
|
0.850 |
GeneticVariation
|
BEFREE |
The single nucleotide polymorphism (SNP) rs17824933 in the CD6 gene has been identified and validated as a genetic risk factor for the development of MS.
|
26844569 |
2016 |
rs17824933
|
|
Multiple Sclerosis
|
|
0.850 |
GeneticVariation
|
BEFREE |
CD6 has recently been identified and validated as risk gene for multiple sclerosis (MS), based on the association of a single nucleotide polymorphism (SNP), rs17824933, located in intron 1.
|
23638056 |
2013 |
rs17824933
|
|
Multiple Sclerosis
|
|
0.850 |
GeneticVariation
|
BEFREE |
In the recently published meta-analysis of multiple sclerosis genome-wide association studies De Jager et al. identified three single nucleotide polymorphisms associated to MS: rs17824933 (CD6), rs1800693 (TNFRSF1A) and rs17445836 (61.5 kb from IRF8).
|
21552549 |
2011 |
rs17824933
|
|
Multiple Sclerosis
|
|
0.850 |
GeneticVariation
|
BEFREE |
Our recent meta-analysis of genome-wide association studies of multiple sclerosis (MS) identified a new susceptibility locus tagged by a single nucleotide polymorphism, rs17824933 (p = 3.8 × 10(-9)), that is found in a block of linkage disequilibrium containing the CD6 gene.
|
21849685 |
2011 |
rs17824933
|
|
Multiple Sclerosis
|
|
0.850 |
GeneticVariation
|
GWASDB |
Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis.
|
21833088 |
2011 |
rs17824933
|
|
Multiple Sclerosis
|
|
0.850 |
GeneticVariation
|
BEFREE |
We also found convincing evidence for allelic imbalance at multiple reporter exonic SNPs in CD6 for two samples heterozygous at the multiple sclerosis-associated variant rs17824933, linking GWA findings with variation in gene expression.
|
19825846 |
2010 |
rs17824933
|
|
Multiple Sclerosis
|
G |
0.850 |
GeneticVariation
|
GWASCAT |
Meta-analysis of genome scans and replication identify CD6, IRF8 and TNFRSF1A as new multiple sclerosis susceptibility loci.
|
19525953 |
2009 |
rs17824933
|
|
Multiple Sclerosis
|
G |
0.850 |
GeneticVariation
|
GWASDB |
Meta-analysis of genome scans and replication identify CD6, IRF8 and TNFRSF1A as new multiple sclerosis susceptibility loci.
|
19525953 |
2009 |
rs11230563
|
|
Inflammatory Bowel Diseases
|
G |
0.800 |
GeneticVariation
|
GWASCAT |
Association analyses identify 38 susceptibility loci for inflammatory bowel disease and highlight shared genetic risk across populations.
|
26192919 |
2015 |
rs11230563
|
|
Inflammatory Bowel Diseases
|
C |
0.800 |
GeneticVariation
|
GWASCAT |
Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
|
23128233 |
2012 |
rs11230563
|
|
Inflammatory Bowel Diseases
|
C |
0.800 |
GeneticVariation
|
GWASDB |
Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
|
23128233 |
2012 |
rs11230563
|
|
Psoriasis
|
|
0.710 |
GeneticVariation
|
BEFREE |
Second, a statistically significant association between CD6 single-nucleotide polymorphisms (rs17824933, rs11230563 and rs12360861) and more severe forms of psoriasis was demonstrated in a cohort of 304 patients at three public hospitals from the metropolitan area of Barcelona.
|
29225340 |
2018 |
rs11230563
|
|
Psoriasis
|
|
0.710 |
GeneticVariation
|
GWASCAT |
Analysis of five chronic inflammatory diseases identifies 27 new associations and highlights disease-specific patterns at shared loci.
|
26974007 |
2016 |
rs11230563
|
|
Crohn Disease
|
|
0.700 |
GeneticVariation
|
GWASCAT |
Analysis of five chronic inflammatory diseases identifies 27 new associations and highlights disease-specific patterns at shared loci.
|
26974007 |
2016 |
rs11230563
|
|
Ankylosing spondylitis
|
|
0.700 |
GeneticVariation
|
GWASCAT |
Analysis of five chronic inflammatory diseases identifies 27 new associations and highlights disease-specific patterns at shared loci.
|
26974007 |
2016 |
rs11230563
|
|
Cholangitis, Sclerosing
|
|
0.700 |
GeneticVariation
|
GWASCAT |
Analysis of five chronic inflammatory diseases identifies 27 new associations and highlights disease-specific patterns at shared loci.
|
26974007 |
2016 |
rs11230563
|
|
Ulcerative Colitis
|
|
0.700 |
GeneticVariation
|
GWASCAT |
Analysis of five chronic inflammatory diseases identifies 27 new associations and highlights disease-specific patterns at shared loci.
|
26974007 |
2016 |
rs11230563
|
|
Ulcerative Colitis
|
G |
0.700 |
GeneticVariation
|
GWASCAT |
Association analyses identify 38 susceptibility loci for inflammatory bowel disease and highlight shared genetic risk across populations.
|
26192919 |
2015 |
rs11230563
|
|
Crohn Disease
|
G |
0.700 |
GeneticVariation
|
GWASCAT |
Association analyses identify 38 susceptibility loci for inflammatory bowel disease and highlight shared genetic risk across populations.
|
26192919 |
2015 |
rs4939488
|
|
Serum albumin measurement
|
|
0.700 |
GeneticVariation
|
GWASDB |
Genome-wide association study identifies multiple loci influencing human serum metabolite levels.
|
22286219 |
2012 |
rs11230563
|
|
Behcet Syndrome
|
|
0.010 |
GeneticVariation
|
BEFREE |
A significantly higher frequency of the CT genotype, and a lower frequency of the CC genotype and C allele of CD6 rs11230563 were observed in BD as compared with controls.
|
27108704 |
2016 |
rs11230563
|
|
Multiple Sclerosis
|
|
0.010 |
GeneticVariation
|
BEFREE |
We identified association of haplotypes composed of two non-synonymous SNPs [rs11230563 (R225W) and rs2074225 (A257V)] in the 2(nd) SRCR domain with susceptibility to MS (P max(T) permutation = 1×10(-4)).
|
23638056 |
2013 |
rs112852289
|
|
Multiple Sclerosis
|
|
0.010 |
GeneticVariation
|
BEFREE |
We identified association of haplotypes composed of two non-synonymous SNPs [rs11230563 (R225W) and rs2074225 (A257V)] in the 2(nd) SRCR domain with susceptibility to MS (P max(T) permutation = 1×10(-4)).
|
23638056 |
2013 |
rs12288280
|
|
Neuromyelitis Optica
|
|
0.010 |
GeneticVariation
|
BEFREE |
Logistic analyses revealed that one SNP in CD6 (rs12288280, P = 0.04) and three SNPs in TNFRSF1A (rs767455, rs4149577 and rs1800693, P = 0.01-0.03) were associated with NMO.
|
22994200 |
2013 |
rs12360861
|
|
Psoriasis
|
|
0.010 |
GeneticVariation
|
BEFREE |
Second, a statistically significant association between CD6 single-nucleotide polymorphisms (rs17824933, rs11230563 and rs12360861) and more severe forms of psoriasis was demonstrated in a cohort of 304 patients at three public hospitals from the metropolitan area of Barcelona.
|
29225340 |
2018 |