rs1057519903
|
|
Astrocytoma
|
|
0.720 |
GeneticVariation
|
BEFREE |
Additionally, H3F3A K27M was not detected in the 2 diffuse astrocytomas.
|
24285547 |
2014 |
rs1057519903
|
|
Astrocytoma
|
|
0.720 |
GeneticVariation
|
BEFREE |
Because H3F3A K27M mutations occur exclusively in pediatric diffuse high-grade astrocytomas, analysis of codon 27 mutational status could be useful in the differential diagnosis of these neoplasms.
|
23429371 |
2013 |
rs1057519903
|
|
Neoplasms
|
|
0.100 |
GeneticVariation
|
BEFREE |
As compared to H3 K27M-wildtype tumo</span>rs, there were no differences in age at diagnosis, sex, tumor grade, contrast enhancement on MRI, extent of resection, or treatment received.
|
30864101 |
2019 |
rs1057519903
|
|
Neoplasms
|
|
0.100 |
GeneticVariation
|
BEFREE |
We demonstrate in this first series of midline GGs that the H3 K27M mutation can occur in association with the BRAF V600E mutation in grade I glioneuronal tumors.
|
27984673 |
2018 |
rs1057519903
|
|
Neoplasms
|
|
0.100 |
GeneticVariation
|
BEFREE |
We found 56 H3.3 K27M</span>-mutant tumors (66%), 6 H3.1 K27M-mutant tumors (7%), and 23 H3-wildtype tumors (27%).
|
29016894 |
2018 |
rs1057519903
|
|
Neoplasms
|
|
0.100 |
GeneticVariation
|
BEFREE |
Histologically, the tumor was considered to be glioblastoma; however, a part of the tumor exhibiting low proliferative activity appeared to be consistent with long-standing H3 K27M-mutant tumors in the literature.Another case was a 69-year-old male.
|
28547652 |
2017 |
rs1057519903
|
|
Neoplasms
|
|
0.100 |
GeneticVariation
|
BEFREE |
Molecular diagnosis of tumor tissue obtained at first and second surgeries revealed H3F3A K27M mutation in both primary and secondary specimens.
|
27392443 |
2016 |
rs1057519903
|
|
Neoplasms
|
|
0.100 |
GeneticVariation
|
BEFREE |
We only identified H3F3A K27M in 2 of 34 cases (5.9%), with both tumors located in the posterior fossa.
|
25231549 |
2015 |
rs1057519903
|
|
Neoplasms
|
|
0.100 |
GeneticVariation
|
BEFREE |
Patients with tumours harbouring a K27M mutation in H3.3 (H3F3A) did not respond clinically to radiotherapy as well, relapsed significantly earlier and exhibited more metastatic recurrences than those in H3.1 (HIST1H3B/C).
|
26399631 |
2015 |
rs1057519903
|
|
Neoplasms
|
|
0.100 |
GeneticVariation
|
BEFREE |
One thalamic tumour had an H3F3A p.K27M.
|
24127995 |
2014 |
rs1057519903
|
|
Neoplasms
|
|
0.100 |
GeneticVariation
|
BEFREE |
We identified an increased number of iCNA in older children compared to infants, and increased iCNA in H3F3A K27M mutant tumours compared to G34R/V and wild-type.
|
24548782 |
2014 |
rs1057519903
|
|
Neoplasms
|
|
0.100 |
GeneticVariation
|
BEFREE |
Evaluation of histone 3 lysine 27 trimethylation (H3K27me3) and enhancer of Zest 2 (EZH2) in pediatric glial and glioneuronal tumors shows decreased H3K27me3 in H3F3A K27M mutant glioblastomas.
|
23414300 |
2013 |
rs1057519903
|
|
Neoplasms
|
|
0.100 |
GeneticVariation
|
BEFREE |
None of the other tumor entities showed H3F3A K27M mutation.
|
23429371 |
2013 |
rs1057519903
|
|
Glioblastoma
|
|
0.080 |
GeneticVariation
|
BEFREE |
Mutated IDH1 R132H protein and H3F3A K27M mutations indicate that a substantial number of GBMc are "metastatic" or "diaschismatic" lesions.
|
30203362 |
2018 |
rs1057519903
|
|
Glioblastoma
|
|
0.080 |
GeneticVariation
|
BEFREE |
Histologically, the tumor was considered to be glioblastoma; however, a part of the tumor exhibiting low proliferative activity appeared to be consistent with long-standing H3 K27M-mutant tumors in the literature.Another case was a 69-year-old male.
|
28547652 |
2017 |
rs1057519903
|
|
Glioblastoma
|
|
0.080 |
GeneticVariation
|
BEFREE |
These results demonstrate that we have developed a new reliable procedure for detecting the H3F3A K27M mutation in pediatric glioblastoma patient samples.
|
26376656 |
2016 |
rs1057519903
|
|
Glioblastoma
|
|
0.080 |
GeneticVariation
|
BEFREE |
Histone H3.3 (H3F3A) mutation in the codon for lysine 27 (K27M) has been found as driver mutations in pediatric glioblastoma and has been suggested to play critical roles in the pathogenesis of thalamic gliomas and diffuse intrinsic pontine gliomas.
|
27392443 |
2016 |
rs1057519903
|
|
Glioblastoma
|
|
0.080 |
GeneticVariation
|
BEFREE |
These results suggest that immunohistochemical detection of H3.3 K27M is a sensitive and specific surrogate for the H3F3A K27M mutation and defines a prognostically poor subset of pediatric GBM.
|
25200322 |
2014 |
rs1057519903
|
|
Glioblastoma
|
|
0.080 |
GeneticVariation
|
BEFREE |
The K27M mutation occurred in 35 of 129 glioblastomas (27.1%) and in 5 of 28 (17.9%) anaplastic astrocytomas.
|
23429371 |
2013 |
rs1057519903
|
|
Glioblastoma
|
|
0.080 |
GeneticVariation
|
BEFREE |
Our results indicate that H3F3A K27M mutant GBMs show decreased H3K27me3 that may be of both diagnostic and biological relevance.
|
23414300 |
2013 |
rs1057519903
|
|
Glioblastoma
|
|
0.080 |
GeneticVariation
|
BEFREE |
Recent studies on high-grade pediatric GBM have identified two recurrent mutations (K27M and G34R/V) in genes encoding histone H3 (H3F3A for H3.3 and HIST1H3B for H3.1).
|
23907119 |
2013 |
rs1057519903
|
|
Diffuse Intrinsic Pontine Glioma
|
|
0.060 |
GeneticVariation
|
BEFREE |
In conclusion, our study demonstrates a high frequency of histone K27M mutations in DIPG when MRI features are carefully assessed, thus confirming the consistency of imaging with biological markers in our institutional series of DIPG.
|
31848724 |
2020 |
rs1057519903
|
|
Diffuse Intrinsic Pontine Glioma
|
|
0.060 |
GeneticVariation
|
BEFREE |
We found conservation of heterozygous K27M mutations in H3F3A (n = 4) or HIST1H3B (n = 3) across all primary, contiguous, and metastatic tumor sites in all DIPGs.
|
26727948 |
2016 |
rs1057519903
|
|
Diffuse Intrinsic Pontine Glioma
|
|
0.060 |
GeneticVariation
|
BEFREE |
In order to facilitate diagnosis of DIPG patients, a quick and reliable method to identify the H3F3A K27M mutation is needed.
|
26376656 |
2016 |
rs1057519903
|
|
Diffuse Intrinsic Pontine Glioma
|
|
0.060 |
GeneticVariation
|
BEFREE |
All DIPG</span> but one were found to harbour either a somatic H3-K27M mutation and/or loss of H3K27 trimethylation.
|
26399631 |
2015 |