|
rs1061622
|
|
Rheumatoid Arthritis
|
|
0.070 |
GeneticVariation
|
BEFREE |
Stratification by disease type indicated an association between the TNFRSF1B rs1061622 allele and non-responders to TNF antagonist in RA (T/G OR 0.69, 95% CI 0.48-0.99, p<0.05) and psoriasis (T/G OR 0.39, 95% CI 0.23-0.67, p<0.001), but not in CD (T/G OR 1.14, 95% CI 0.57-0.93, p=0.57).
|
26071216 |
2015 |
|
rs1061622
|
|
Rheumatoid Arthritis
|
|
0.070 |
GeneticVariation
|
BEFREE |
Associations between functional TNFR2 196 M/R polymorphisms and susceptibility to rheumatoid arthritis: a meta-analysis.
|
24777778 |
2014 |
|
rs1061622
|
|
Rheumatoid Arthritis
|
|
0.070 |
GeneticVariation
|
BEFREE |
To assess the effect of a functional polymorphism (676T>G, M196R) in the tumour necrosis factor receptor super family 1b (TNFSF1b) gene on disease activity, radiological joint damage and response to infliximab and adalimumab treatment in patients with rheumatoid arthritis (RA).
|
18385279 |
2008 |
|
rs1061622
|
|
Rheumatoid Arthritis
|
|
0.070 |
GeneticVariation
|
BEFREE |
Influence of FCGR3A-V212F and TNFRSF1B-M196R genotypes in patients with rheumatoid arthritis treated with infliximab therapy.
|
18565259 |
2008 |
|
rs1061622
|
|
Rheumatoid Arthritis
|
|
0.070 |
GeneticVariation
|
BEFREE |
Tumor necrosis factor receptor 2 M196R polymorphism in rheumatoid arthritis and osteoarthritis: relationship with sTNFR2 levels and clinical features.
|
16871413 |
2006 |
|
rs1061622
|
|
Rheumatoid Arthritis
|
|
0.070 |
GeneticVariation
|
BEFREE |
The results of the present study support the hypothesis that there is an association between the TNFRII 196 M/R gene polymorphism and the functional severity of early RA.
|
15022314 |
2004 |
|
rs1061622
|
|
Rheumatoid Arthritis
|
|
0.070 |
GeneticVariation
|
BEFREE |
To assess the association between the tumour necrosis factor receptor 2 (TNFR2) 196 M/R single-nucleotide polymorphism and rheumatoid arthritis (RA) severity by taking advantage of the extremes of phenotype that exist in arthritis.
|
15252214 |
2004 |
|
rs1061622
|
|
Lupus Erythematosus, Systemic
|
|
0.040 |
GeneticVariation
|
BEFREE |
Our findings suggest that the association between cigarette smoking and SLE could be differentiated by the TNFRSF1B rs1061622 T allele among female Japanese subjects.
|
19684152 |
2009 |
|
rs1061622
|
|
Lupus Erythematosus, Systemic
|
|
0.040 |
GeneticVariation
|
BEFREE |
In conclusion, no skewed distribution of TNFR2 196 R/M polymorphism was found in Korean patients with SLE compared with healthy controls.
|
11600223 |
2001 |
|
rs1061622
|
|
Lupus Erythematosus, Systemic
|
|
0.040 |
GeneticVariation
|
BEFREE |
Lack of association between the Met196Arg polymorphism in the TNFR2 gene and autoimmune diseases accompanied by vasculitis including SLE in Japanese.
|
11169260 |
2001 |
|
rs1061622
|
|
Lupus Erythematosus, Systemic
|
|
0.040 |
GeneticVariation
|
BEFREE |
Thus, among the non-synonymous cSNPs, only nt587 (T-->G) (M196R) was found to be significantly associated with SLE in Japanese.
|
11197692 |
2000 |
|
rs1061622
|
|
Paranoid Schizophrenia
|
|
0.020 |
GeneticVariation
|
BEFREE |
We examined the association of the three single nucleotide polymorphisms (rs3397, rs1061622, and rs1061624) in <i>TNFR2</i> gene with a predisposition to and psychopathology of paranoid schizophrenia in Caucasian population.
|
30254506 |
2018 |
|
rs1061622
|
|
Psoriasis
|
|
0.020 |
GeneticVariation
|
BEFREE |
Stratification by disease type indicated an association between the TNFRSF1B rs1061622 allele and non-responders to TNF antagonist in RA (T/G OR 0.69, 95% CI 0.48-0.99, p<0.05) and psoriasis (T/G OR 0.39, 95% CI 0.23-0.67, p<0.001), but not in CD (T/G OR 1.14, 95% CI 0.57-0.93, p=0.57).
|
26071216 |
2015 |
|
rs1061622
|
|
Autoimmune Diseases
|
|
0.020 |
GeneticVariation
|
BEFREE |
We conducted a meta-analysis of studies on the association between TNFRSF1B rs1061622 T/G polymorphism or TNFRSF1A A/G rs767455 polymorphism and non-responsiveness to anti-TNF therapy in autoimmune diseases.
|
26071216 |
2015 |
|
rs1061622
|
|
Psoriasis
|
|
0.020 |
GeneticVariation
|
BEFREE |
In conclusion, we report a significant association between the TNFRSF1B p.M196R variant and the risk for psoriasis and the response to treatment with anti-TNF or anti-Il-12/Il-23.
|
25537528 |
2015 |
|
rs1061622
|
|
Paranoid Schizophrenia
|
|
0.020 |
GeneticVariation
|
BEFREE |
Association of the Met-196-Arg variation of human tumor necrosis factor receptor 2 (TNFR2) with paranoid schizophrenia.
|
20842464 |
2011 |
|
rs1061622
|
|
Hyperandrogenism
|
|
0.020 |
GeneticVariation
|
BEFREE |
The opposite behaviors in terms of clinical expressivity detected for CAPN-UCSNP44 and TNFR2-M196R rare variants suggest these variants to be sensitizing and protective factors respectively in adrenal hyperandrogenism.
|
19039234 |
2009 |
|
rs1061622
|
|
Hyperandrogenism
|
|
0.020 |
GeneticVariation
|
BEFREE |
In conclusion, the M196R (676 T-->G) variant in exon 6 of TNFRSF1B is associated with hyperandrogenism and PCOS, further suggesting a role for inflammatory cytokines in the pathogenesis of these disorders.
|
12161545 |
2002 |
|
rs1061622
|
|
Autoimmune Diseases
|
|
0.020 |
GeneticVariation
|
BEFREE |
Lack of association between the Met196Arg polymorphism in the TNFR2 gene and autoimmune diseases accompanied by vasculitis including SLE in Japanese.
|
11169260 |
2001 |
|
rs1061622
|
|
Depressed mood
|
|
0.010 |
GeneticVariation
|
BEFREE |
It is concluded that the association of <i>TNF-RII</i> rs1061622 with depression is longitudinally different in Chinese Han adolescents after the 2008 Wenchuan earthquake.
|
29799484 |
2018 |
|
rs1061622
|
|
Liver diseases
|
|
0.010 |
GeneticVariation
|
BEFREE |
Nevertheless, no association was found between rs1061622 polymorphism and HBV-related liver diseases in the overall or subgroup analyses.
|
29915336 |
2018 |
|
rs1061622
|
|
Schizophrenia
|
|
0.010 |
GeneticVariation
|
BEFREE |
Our case-control study (401 patients and 657 controls) revealed that the genetic variants of rs3397, rs1061622, and rs1061624 in the <i>TNFR2</i> gene are associated with a higher risk of developing schizophrenia and more severe course in men.
|
30254506 |
2018 |
|
rs1061622
|
|
Ankylosing spondylitis
|
|
0.010 |
GeneticVariation
|
BEFREE |
Only rs1061622 was significantly associated with long-term efficacy of etanercept: the TG genotype of rs1061622 worsened ASAS20 and ASAS40 responses at 12 months (P = .021 and .041, respectively).The results suggest that TNFRSF1A and TNFRSF1B polymorphisms were associated with susceptibility, severity, and the long-term therapeutic efficacy of etanercept of patients with AS.
|
30075559 |
2018 |
|
rs1061622
|
|
Depressive disorder
|
|
0.010 |
GeneticVariation
|
BEFREE |
It is concluded that the association of <i>TNF-RII</i> rs1061622 with depression is longitudinally different in Chinese Han adolescents after the 2008 Wenchuan earthquake.
|
29799484 |
2018 |
|
rs1061622
|
|
Mental Depression
|
|
0.010 |
GeneticVariation
|
BEFREE |
It is concluded that the association of <i>TNF-RII</i> rs1061622 with depression is longitudinally different in Chinese Han adolescents after the 2008 Wenchuan earthquake.
|
29799484 |
2018 |