|
rs121912656
|
|
Li-Fraumeni Syndrome
|
T |
0.800 |
CausalMutation
|
CLINVAR |
The p53-reactivating small molecule RITA induces senescence in head and neck cancer cells.
|
25119136 |
2014 |
|
rs121912656
|
|
Li-Fraumeni Syndrome
|
|
0.800 |
GeneticVariation
|
UNIPROT |
American Society of Clinical Oncology Expert Statement: collection and use of a cancer family history for oncology providers.
|
24493721 |
2014 |
|
rs121912656
|
|
Li-Fraumeni Syndrome
|
T |
0.800 |
CausalMutation
|
CLINVAR |
Two hot spot mutant p53 mouse models display differential gain of function in tumorigenesis.
|
23538418 |
2013 |
|
rs121912656
|
|
Li-Fraumeni Syndrome
|
T |
0.800 |
CausalMutation
|
CLINVAR |
TP53 mutations and polymorphisms in primary myelofibrosis.
|
22052707 |
2012 |
|
rs121912656
|
|
Li-Fraumeni Syndrome
|
T |
0.800 |
CausalMutation
|
CLINVAR |
A comprehensive study of TP53 mutations in chronic lymphocytic leukemia: Analysis of 1287 diagnostic and 1148 follow-up CLL samples.
|
21232794 |
2011 |
|
rs121912656
|
|
Li-Fraumeni Syndrome
|
T |
0.800 |
CausalMutation
|
CLINVAR |
Analysis of the DNA-binding activity of p53 mutants using functional protein microarrays and its relationship to transcriptional activation.
|
20128691 |
2010 |
|
rs121912656
|
|
Li-Fraumeni Syndrome
|
T |
0.800 |
CausalMutation
|
CLINVAR |
Transcriptional functionality of germ line p53 mutants influences cancer phenotype.
|
17606709 |
2007 |
|
rs121912656
|
|
Li-Fraumeni Syndrome
|
|
0.800 |
GeneticVariation
|
UNIPROT |
American Cancer Society guidelines for breast screening with MRI as an adjunct to mammography.
|
17392385 |
2007 |
|
rs121912656
|
|
Li-Fraumeni Syndrome
|
T |
0.800 |
CausalMutation
|
CLINVAR |
A Li-Fraumeni syndrome family with retained heterozygosity for a germline TP53 mutation in two tumors.
|
12885464 |
2003 |
|
rs121912656
|
|
Li-Fraumeni Syndrome
|
T |
0.800 |
CausalMutation
|
CLINVAR |
Understanding the function-structure and function-mutation relationships of p53 tumor suppressor protein by high-resolution missense mutation analysis.
|
12826609 |
2003 |
|
rs121912656
|
|
Li-Fraumeni Syndrome
|
|
0.800 |
GeneticVariation
|
UNIPROT |
Hereditary TP53 codon 292 and somatic P16INK4A codon 94 mutations in a Li-Fraumeni syndrome family.
|
10484981 |
1999 |
|
rs121912656
|
|
Li-Fraumeni Syndrome
|
|
0.800 |
GeneticVariation
|
UNIPROT |
A germline missense mutation R337C in exon 10 of the human p53 gene.
|
9452042 |
1998 |
|
rs121912656
|
|
Li-Fraumeni Syndrome
|
|
0.800 |
GeneticVariation
|
UNIPROT |
An extended Li-Fraumeni kindred with gastric carcinoma and a codon 175 mutation in TP53.
|
8825920 |
1995 |
|
rs121912656
|
|
Li-Fraumeni Syndrome
|
T |
0.800 |
CausalMutation
|
CLINVAR |
Heterogeneity in Li-Fraumeni families: p53 mutation analysis and immunohistochemical staining.
|
7783166 |
1995 |
|
rs121912656
|
|
Li-Fraumeni Syndrome
|
|
0.800 |
GeneticVariation
|
UNIPROT |
Germ-line p53 mutations in 15 families with Li-Fraumeni syndrome.
|
7887414 |
1995 |
|
rs121912656
|
|
Li-Fraumeni Syndrome
|
T |
0.800 |
CausalMutation
|
CLINVAR |
Prevalence and spectrum of germline mutations of the p53 gene among patients with sarcoma.
|
1565143 |
1992 |
|
rs121912656
|
|
Li-Fraumeni Syndrome
|
T |
0.800 |
CausalMutation
|
CLINVAR |
Screening for germ line TP53 mutations in breast cancer patients.
|
1591732 |
1992 |
|
rs121912656
|
|
Li-Fraumeni Syndrome
|
|
0.800 |
GeneticVariation
|
UNIPROT |
Hereditary and acquired p53 gene mutations in childhood acute lymphoblastic leukemia.
|
1737852 |
1992 |
|
rs121912656
|
|
Li-Fraumeni Syndrome
|
|
0.800 |
GeneticVariation
|
UNIPROT |
Germline mutations of the p53 tumor-suppressor gene in children and young adults with second malignant neoplasms.
|
1565144 |
1992 |
|
rs121912656
|
|
Li-Fraumeni Syndrome
|
|
0.800 |
GeneticVariation
|
UNIPROT |
A germ line mutation in exon 5 of the p53 gene in an extended cancer family.
|
1933902 |
1991 |
|
rs121912656
|
|
Li-Fraumeni Syndrome
|
T |
0.800 |
CausalMutation
|
CLINVAR |
Germ-line transmission of a mutated p53 gene in a cancer-prone family with Li-Fraumeni syndrome.
|
2259385 |
1991 |
|
rs121912656
|
|
Li-Fraumeni Syndrome
|
|
0.800 |
GeneticVariation
|
UNIPROT |
Germ-line transmission of a mutated p53 gene in a cancer-prone family with Li-Fraumeni syndrome.
|
2259385 |
1991 |
|
rs121912656
|
|
Li-Fraumeni Syndrome
|
|
0.800 |
GeneticVariation
|
UNIPROT |
Germ line p53 mutations in a familial syndrome of breast cancer, sarcomas, and other neoplasms.
|
1978757 |
1990 |
|
rs121912656
|
|
Li-Fraumeni Syndrome
|
A |
0.800 |
GeneticVariation
|
CLINVAR |
|
|
|
|
rs121912656
|
|
Squamous cell carcinoma of the head and neck
|
|
0.710 |
GeneticVariation
|
BEFREE |
We show here that overexpression of the GOF mutant p53 G245D and other GOF p53 mutants enhances the invasive cell growth of p53-deficient head and neck squamous cell carcinoma (HNSCC) UM-SCC-1 cells both in in vitro three-dimensional culture and in an in vivo orthotopic nude mouse model of HNSCC through a novel transcription-independent mechanism.
|
29269868 |
2018 |