|
rs1799969
|
|
Endometriosis
|
|
0.040 |
GeneticVariation
|
BEFREE |
This study suggests that polymorphisms K469E, G241R, and G634C are not associated with increased susceptibility to endometriosis in Brazilian women.
|
27614631 |
2016 |
|
rs1799969
|
|
Endometriosis
|
|
0.040 |
GeneticVariation
|
BEFREE |
Reported associations of the G241R and K469E polymorphisms of the intercellular adhesion molecule-1 gene (ICAM-1) gene with endometriosis have differed in magnitude.
|
25859827 |
2015 |
|
rs1799969
|
|
Endometriosis
|
|
0.040 |
GeneticVariation
|
BEFREE |
The K469E and G241R polymorphisms in the ICAM-1 gene and the C-634G polymorphism in the IL-6 gene may not be genetic factors related to susceptibility to advanced-stage endometriosis in the Korean population.
|
20160446 |
2010 |
|
rs1799969
|
|
Endometriosis
|
|
0.040 |
GeneticVariation
|
BEFREE |
While the functional correlate of the G/R241 polymorphism remains unclear, this finding indicates that a genetic polymorphism in the ICAM-1 gene domain may contribute to the susceptibility to endometriosis.
|
12529420 |
2003 |
|
rs1799969
|
|
Behcet Syndrome
|
|
0.030 |
GeneticVariation
|
BEFREE |
In addition, the meta-analysis revealed a significant association between the ICAM-1 G241R R allele and Behcet's disease</span> (B</span>D) (OR = 3.261, 95% CI = 1.653-6.434, p = 0.001), but not giant cell arteritis.
|
27894415 |
2016 |
|
rs1799969
|
|
Rheumatoid Arthritis
|
|
0.030 |
GeneticVariation
|
BEFREE |
Moreover, the meta-analysis indicated an association between RA and the R allele and RR+ RG genotype of the ICAM-1 G241R</span> polymorphism (OR = 2.014, 95% CI = 1.215-3.339, p = 0.007; OR = 2.394, 95% CI = 1.354-4.235, p = 0.003).
|
27894415 |
2016 |
|
rs1799969
|
|
Behcet Syndrome
|
|
0.030 |
GeneticVariation
|
BEFREE |
Behçet's disease was associated with the ICAM1 E469, genotype ICAM1 469 E/E, ICAM1 241 G/R polymorphisms in different ethnic groups.
|
24645721 |
2014 |
|
rs1799969
|
|
Rheumatoid Arthritis
|
|
0.030 |
GeneticVariation
|
BEFREE |
To investigate the association of sICAM-1 and sVCAM-1 with ICAM1 721G>A and VCAM1 1238G>C polymorphisms and rheumatoid arthritis (RA) clinical activity, sixty RA patients and 60 healthy non-related subjects (HS) matched for age and sex were recruited.
|
19597294 |
2009 |
|
rs1799969
|
|
Rheumatoid Arthritis
|
|
0.030 |
GeneticVariation
|
BEFREE |
Our preliminary findings show that G/R 241 polymorphism of ICAM-1 is associated with RA, and that this confers a reduced risk of extra-articular manifestations and is associated with a slow rate of joint destruction.
|
11072593 |
2001 |
|
rs1799969
|
|
Behcet Syndrome
|
|
0.030 |
GeneticVariation
|
BEFREE |
Our findings show that G/R 241 polymorphism of ICAM-1 is associated with BD susceptibility.
|
11409120 |
2001 |
|
rs1799969
|
|
Guillain-Barre Syndrome
|
|
0.020 |
GeneticVariation
|
BEFREE |
We found a significant protective association between heterozygous GA genotype in ICAM1 (241Gly/Arg) and GBS (p < .047).
|
31464097 |
2019 |
|
rs1799969
|
|
Guillain-Barre Syndrome
|
|
0.020 |
GeneticVariation
|
BEFREE |
IL-17 (Glu126Gly) mutant and ICAM-1 (Gly241Arg) heterozygous genotypes were strongly associated with increased risk of GBS (p < 0.016; OR = 3.706, 95% CI = 1.28-10.67; p < 0.001; OR = 4.148, 95% CI = 2.119-8.119, respectively).
|
27595159 |
2017 |
|
rs1799969
|
|
Polycystic Ovary Syndrome
|
|
0.020 |
GeneticVariation
|
BEFREE |
Although Gly241Arg polymorphism have not shown significant association with PCOS.
|
27039809 |
2016 |
|
rs1799969
|
|
Giant Cell Arteritis
|
|
0.020 |
GeneticVariation
|
BEFREE |
In addition, the meta-analysis revealed a significant association between the ICAM-1 G241R R allele and Behcet's disease (BD) (OR = 3.261, 95% CI = 1.653-6.434, p = 0.001), but not giant cell arteritis.
|
27894415 |
2016 |
|
rs1799969
|
|
Graves Disease
|
|
0.020 |
GeneticVariation
|
BEFREE |
Although there is not association between ICAM1 (G241R and K469E), VCAM1 (T-1591C and T-833C), and E-selectin (S128R) SNPs and susceptibility to GD, higher anti-TPO in E-selectin 128 SR + RR, and lower TSH in ICAM1 469 KE + EE subjects suspect that these genotypes are prone to increased antithyroid autoantibody production with more accentuated TSH suppression in GD.
|
23242661 |
2013 |
|
rs1799969
|
|
Polycystic Ovary Syndrome
|
|
0.020 |
GeneticVariation
|
BEFREE |
This study examined the possible association of G241R and K469E single nucleotide polymorphisms (SNPs) of ICAM-1 gene with the occurrence and clinical/biochemical characteristics of polycystic ovary syndrome (PCOS).
|
21717173 |
2011 |
|
rs1799969
|
|
Colorectal Carcinoma
|
|
0.020 |
GeneticVariation
|
BEFREE |
The findings indicate that polymorphisms of G241R are rare in Chinese population and that KK genotype of ICAM-1 K469E is significantly associated with well differentiation of CRC.
|
19822019 |
2009 |
|
rs1799969
|
|
Celiac Disease
|
|
0.020 |
GeneticVariation
|
BEFREE |
Therefore, in our population our results discard the important previously described role of ICAM1 G241R in celiac disease.
|
18703101 |
2008 |
|
rs1799969
|
|
Graves Disease
|
|
0.020 |
GeneticVariation
|
BEFREE |
We found no association of G241R and K469E polymorphisms of the ICAM-1gene with the development of GD in a Chinese population.
|
17873320 |
2007 |
|
rs1799969
|
|
Inflammatory Bowel Diseases
|
|
0.020 |
GeneticVariation
|
BEFREE |
The aim of this study was to investigate polymorphisms in the NOD2/CARD15 (R702W, G908R, and 3020insC), NOD1/CARD4 (E266K, D372N), and ICAM-1 (G241R, K469E) genes, which are known to be associated with inflammation, in Turkish patients with inflammatory bowel disease and healthy control groups.
|
16741608 |
2006 |
|
rs1799969
|
|
Celiac Disease
|
|
0.020 |
GeneticVariation
|
BEFREE |
No significant differences were observed in the F206L polymorphism of L-selectin, or the G241R and E469K polymorphisms in the ICAM-1 gene in CD.
|
16916660 |
2006 |
|
rs1799969
|
|
Inflammatory Bowel Diseases
|
|
0.020 |
GeneticVariation
|
BEFREE |
In the second approach, we typed four nonsynonymous polymorphisms in genes C3 (R102G and L314P) and ICAM1 (G241R and K469E) in four independent cohorts totaling 2178 IBD cases.
|
16570073 |
2006 |
|
rs1799969
|
|
Colorectal Carcinoma
|
|
0.020 |
GeneticVariation
|
BEFREE |
We studied the association of SNPs in the IL-6 (-174G>C), IL-8 (-251T>A), TNFalpha (-308G>A), ICAM-1 (R241G and K469E), and PPARgamma (Pro12Ala) genes and the risk of CRC.
|
16937502 |
2006 |
|
rs1799969
|
|
Giant Cell Arteritis
|
|
0.020 |
GeneticVariation
|
BEFREE |
Our findings show that G/R 241 polymorphism of ICAM-1 is associated with PMR/GCA susceptibility and confers an increased risk of relapse/recurrence in PMR.
|
10813290 |
2000 |
|
rs1799969
|
|
Neoplasms
|
|
0.010 |
GeneticVariation
|
BEFREE |
Genomic DNA was isolated from whole blood for the analysis of <i>VEGF-A</i> (rs2010963, 1570360, rs699947), <i>ICAM-1</i> (rs5498, rs1799969) SNPs and from tumor tissue for the detection of genomic variants in <i>KRAS</i>, <i>NRAS</i>, <i>BRAF</i> genes.
|
31752122 |
2019 |