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rs1801275
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|
ATOPY, SUSCEPTIBILITY TO (finding)
|
G |
0.700 |
SusceptibilityMutation
|
CLINVAR |
|
|
|
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rs1801275
|
|
Asthma
|
|
0.100 |
GeneticVariation
|
BEFREE |
IL-4 rs2243250 and rs2070874 allele and genotype frequencies did not significantly differ between the asthma and control groups (P > 0.05), but those of IL-4R rs1801275 did (P < 0.05).
|
27819719 |
2016 |
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rs1801275
|
|
Asthma
|
|
0.100 |
GeneticVariation
|
BEFREE |
The results of this meta-analysis suggested that the IL4RA I50V and Q551R polymorphisms may be risk factors for developing asthma.
|
23922687 |
2013 |
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rs1801275
|
|
Asthma
|
|
0.100 |
GeneticVariation
|
BEFREE |
Polymorphisms rs2243250 and rs2070874 of IL-4 and rs1801275 and rs1805011 of IL4R were associated with asthma.
|
23924473 |
2013 |
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rs1801275
|
|
Asthma
|
|
0.100 |
GeneticVariation
|
BEFREE |
We found an association between atopic bronchial asthma and the SNPs Gln576Arg in IL4RA and -33C>T in IL4.
|
22533235 |
2012 |
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rs1801275
|
|
Asthma
|
|
0.100 |
GeneticVariation
|
BEFREE |
The IL4RA Q551R SNP is associated with nonatopic asthma in Slovenian children.
|
20517665 |
2010 |
|
rs1801275
|
|
Asthma
|
|
0.100 |
GeneticVariation
|
BEFREE |
The combined analysis of two IL4RA single nucleotide polymorphisms (SNPs) (I50V and Q551R) showed an association with asthma: IL4RA V50/Q551 was associated with risk (OR = 2.48, p = 0.007) whereas the IL4RA V50R551 haplotype was associated with protection (OR = 0.31, p = 0.003).
|
18849614 |
2009 |
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rs1801275
|
|
Asthma
|
|
0.100 |
GeneticVariation
|
BEFREE |
Our findings indicate that the Q576R polymorphism directly promotes asthma in carrier populations by selectively augmenting IL-4R alpha-dependent signaling.
|
19770271 |
2009 |
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rs1801275
|
|
Asthma
|
|
0.100 |
GeneticVariation
|
BEFREE |
We sought to determine the average risk of asthma associated with the I50V and Q551R IL4R variants based on the results of case-control studies reported in the literature.
|
17586032 |
2007 |
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rs1801275
|
|
Asthma
|
|
0.100 |
GeneticVariation
|
BEFREE |
We aimed to investigate the association of the polymorphisms for IL-4 (C-589T), IL-4R alpha (Gln576Arg), TNF-alpha (G-308A) and LT-alpha (A252G) genes as candidates and asthma in adult Hong Kong Chinese population.
|
17536219 |
2007 |
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rs1801275
|
|
Asthma
|
|
0.100 |
GeneticVariation
|
BEFREE |
To determine whether Ile50Val and Q576R polymorphisms of IL-4 receptor alpha chain gene were associated with asthma and higher level of total IgE in Chinese, Malay and Indian populations.
|
16757160 |
2007 |
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rs1801275
|
|
Asthma
|
|
0.100 |
GeneticVariation
|
BEFREE |
Polymorphisms in the interleukin-4 (C-590T), interleukin-4 receptor (ile50val and gln576arg), and interleukin-13 (arg130gln) genes have been described as susceptibility alleles for asthma.
|
17284225 |
2007 |
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rs1801275
|
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Asthma
|
|
0.100 |
GeneticVariation
|
BEFREE |
For the Arg551Gln polymorphism, the combined genotype frequency of the Arg/Gln heterozygote and the Arg/Arg homozygote was significantly higher in atopic asthmatics (27.6%) than in healthy children (16.0%) (odds ratio (OR) = 1.97, 95% CI (confidence interval) = 1.07-3.71).
|
15298559 |
2004 |
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rs1801275
|
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Asthma
|
|
0.100 |
GeneticVariation
|
BEFREE |
Single nucleotide polymorphisms (SNPs) leading to the protein exchanges I50V, E375A, C406R, S478P and Q551R in the IL-4 receptor alpha were examined for allele sharing in sibs with asthma.
|
12047364 |
2002 |
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rs1801275
|
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Glioma
|
|
0.050 |
GeneticVariation
|
BEFREE |
Univariate analysis showed that IL4R rs1801275 was significantly associated with overall survival of glioma and astrocytoma patients (P < 0.05).
|
27495027 |
2016 |
|
rs1801275
|
|
Glioma
|
|
0.050 |
GeneticVariation
|
BEFREE |
Subgroup analysis by ethnicity revealed that the IL-4Rα rs1801275</span> variant G and GG + AG exerted a decreased risk effect on the development of glioma among Asians, but not Caucasians (G vs. A, OR = 0.81, 95% CI = 0.69-0.95, P OR = 0.011; GG + AG vs. AA, OR = 0.80, 95% CI = 0.66-0.96, P OR = 0.018).
|
23979976 |
2014 |
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rs1801275
|
|
Glioma
|
|
0.050 |
GeneticVariation
|
BEFREE |
This meta-analysis suggests that the IL13 rs20541 but not the IL-4Rα rs1801275 polymorphism may be a genetic predictor for glioma.
|
23395224 |
2013 |
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rs1801275
|
|
Glioma
|
|
0.050 |
GeneticVariation
|
BEFREE |
Overall, we found three protective alleles for glioma in patients: the allele "G" of rs1801275 in the IL4R gene by allele model (odds ratio [OR], 0.71; 95% confidence interval [CI], 0.50-0.99; P=0.04) and dominant model (OR, 0.67; 95% CI, 0.46-0.99; P=0.04) analysis respectively, the allele "T" of rs17748 in the TREH gene by recessive model (OR, 0.48; 95% CI, 0.23-1.01; P=0.05) analysis, and the allele "G" of rs6470745 in CCDC26 gene by recessive model (OR, 0.48; 95% CI, 0.26-0.89; P=0.02) analysis.
|
22369735 |
2012 |
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rs1801275
|
|
Glioma
|
|
0.050 |
GeneticVariation
|
BEFREE |
Interaction between IL-13 Arg130Gln and IL-4Ra Gln576Arg was observed in decreasing glioma risk (p=0.045).
|
21196282 |
2011 |
|
rs1801275
|
|
Multiple Sclerosis
|
|
0.040 |
GeneticVariation
|
BEFREE |
The present case-control study inspected the association between seven single nucleotide polymorphisms (SNPs) of IL4 (IL4<sub>-1098</sub>: rs2243248, IL4<sub>-590</sub>: rs2243250, and IL4<sub>-33</sub>: rs2070874), IL4RA (IL4RA<sub>+1902</sub>: rs1801275), and IL10 (IL10<sub>-1082</sub>: rs1800896, IL10<sub>-819</sub>: rs1800871, and IL10<sub>-592</sub>: rs1800872) genes and MS in Iraqi patients.
|
31264107 |
2019 |
|
rs1801275
|
|
Multiple Sclerosis
|
|
0.040 |
GeneticVariation
|
BEFREE |
The meta-analysis indicates that the T allele, CT and TT genotype of polymorphism of IL4 rs2243250 (C/T) may reduce the risk of MS in Caucasian populations, while polymorphisms of IL4 I3(709)*VNTR and IL4R rs1801275 may not associated with risk of MS in Caucasian populations.
|
27000232 |
2016 |
|
rs1801275
|
|
Rheumatoid Arthritis
|
|
0.040 |
GeneticVariation
|
BEFREE |
This meta-analysis indicates that the I50V polymorphism of IL-4R gene may confer susceptibility to RA; up to now, there is still not enough evidence to reveal the association of the IL-4R gene Q551R polymorphism with RA risk.
|
23972290 |
2013 |
|
rs1801275
|
|
Rheumatoid Arthritis
|
|
0.040 |
GeneticVariation
|
BEFREE |
The frequencies of IL-4Rα Q576R genotype were significantly decreased in patients with erosive RA compared to patients with nonerosive RA (31.6% versus 48.2%, OR: 2.7, 95% CI: 1-7.7, P: 0.04).
|
21497535 |
2012 |
|
rs1801275
|
|
Rheumatoid Arthritis
|
|
0.040 |
GeneticVariation
|
BEFREE |
To determine whether IL4R single-nucleotide polymorphisms (SNPs) rs1805010 (I50V) and rs1801275 (Q551R), which have been associated with disease severity in rheumatoid arthritis (RA) patients of European ancestry, relate to the presence of rheumatoid nodules and radiographic erosions in African Americans.
|
20444266 |
2010 |
|
rs1801275
|
|
Multiple Sclerosis
|
|
0.040 |
GeneticVariation
|
BEFREE |
It was also observed a significant (p=0.016) increase for the IL4R* Q551R CC genotype in AF-MS compared to those of Caucasian ethnicity (AF-MS= 21.62%; CA-MS= 4.35%).
|
17420820 |
2007 |