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rs2069837
|
|
Takayasu Arteritis
|
|
0.720 |
GeneticVariation
|
BEFREE |
Previous work has revealed a genetic association between Takayasu arteritis and a non-coding genetic variant in an enhancer region within <i>IL6</i> (rs2069837 A/G).
|
31315839 |
2019 |
|
rs2069837
|
|
Takayasu Arteritis
|
|
0.720 |
GeneticVariation
|
GWASCAT |
We identified genetic susceptibility loci for Takayasu arteritis with a genome-wide level of significance in IL6 (rs2069837) (odds ratio [OR] 2.07, P = 6.70 × 10(-9)), RPS9/LILRB3 (rs11666543) (OR 1.65, P = 2.34 × 10(-8)), and an intergenic locus on chromosome 21q22 (rs2836878) (OR 1.79, P = 3.62 × 10(-10)).
|
25604533 |
2015 |
|
rs2069837
|
|
Takayasu Arteritis
|
|
0.720 |
GeneticVariation
|
BEFREE |
We identified genetic susceptibility loci for Takayasu arteritis with a genome-wide level of significance in IL6 (rs2069837) (odds ratio [OR] 2.07, P = 6.70 × 10(-9)), RPS9/LILRB3 (rs11666543) (OR 1.65, P = 2.34 × 10(-8)), and an intergenic locus on chromosome 21q22 (rs2836878) (OR 1.79, P = 3.62 × 10(-10)).
|
25604533 |
2015 |
|
rs2069837
|
|
Longevity
|
A |
0.700 |
GeneticVariation
|
GWASCAT |
A meta-analysis of genome-wide association studies identifies multiple longevity genes.
|
31413261 |
2019 |
|
rs2069837
|
|
Longevity
|
A |
0.700 |
GeneticVariation
|
GWASCAT |
Novel loci and pathways significantly associated with longevity.
|
26912274 |
2016 |
|
rs2069837
|
|
Cervix carcinoma
|
|
0.020 |
GeneticVariation
|
BEFREE |
Minor allele of rs1800795 and rs2069837 and its interaction were associated with increased cervical cancer risk.
|
27535759 |
2016 |
|
rs2069837
|
|
Malignant tumor of cervix
|
|
0.020 |
GeneticVariation
|
BEFREE |
Minor allele of rs1800795 and rs2069837 and its interaction were associated with increased cervical cancer risk.
|
27535759 |
2016 |
|
rs2069837
|
|
cervical cancer
|
|
0.020 |
GeneticVariation
|
BEFREE |
Minor allele of rs1800795 and rs2069837 and its interaction were associated with increased cervical cancer risk.
|
27535759 |
2016 |
|
rs2069837
|
|
cervical cancer
|
|
0.020 |
GeneticVariation
|
BEFREE |
We concluded that the IL6-rs2069837 SNP may be a marker for susceptibility to cervical cancer in Eastern Chinese women by a possible mechanism of altering the IL6 protein expression.
|
23180271 |
2013 |
|
rs2069837
|
|
Malignant tumor of cervix
|
|
0.020 |
GeneticVariation
|
BEFREE |
We concluded that the IL6-rs2069837 SNP may be a marker for susceptibility to cervical cancer in Eastern Chinese women by a possible mechanism of altering the IL6 protein expression.
|
23180271 |
2013 |
|
rs2069837
|
|
Cervix carcinoma
|
|
0.020 |
GeneticVariation
|
BEFREE |
We concluded that the IL6-rs2069837 SNP may be a marker for susceptibility to cervical cancer in Eastern Chinese women by a possible mechanism of altering the IL6 protein expression.
|
23180271 |
2013 |
|
rs2069837
|
|
Papillary thyroid carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
Additionally, rs2069837 variant elevated the PTC risk based on dominant model (p = 0.041).
|
31288714 |
2019 |
|
rs2069837
|
|
Tuberculosis
|
|
0.010 |
GeneticVariation
|
BEFREE |
The G allele at rs2069837 of IL6 was significantly more common in controls than in TB patients in the Han population.
|
30792445 |
2019 |
|
rs2069837
|
|
Diabetic Nephropathy
|
|
0.010 |
GeneticVariation
|
BEFREE |
This meta-analysis indicated that IL-6 rs1800795, rs1800796 and rs1800797 played important roles in DN development while IL-6 rs2069837 and rs2069840 might not be related to DN.
|
31451183 |
2019 |
|
rs2069837
|
|
Tuberculosis, Pulmonary
|
|
0.010 |
GeneticVariation
|
BEFREE |
We found correlations between one SNP in IL6 (rs2069837 <i>p</i> = 6.63E-11), seven SNPs in <i>IL10</i> (rs1554286 <i>p</i> = 6.87E-20, rs1518111 <i>p</i> = 6.11E-11, rs3021094 <i>p</i> = 6.75E-29, rs3790622 <i>p</i> = 2.40E-06, rs3024490 <i>p</i> = 6.73E-11, rs1800872 <i>p</i> = 6.18E-11, rs1800871 <i>p</i> = 6.73E-11) and incidences of PTB.
|
29662655 |
2018 |
|
rs2069837
|
|
Chronic Periodontitis
|
|
0.010 |
GeneticVariation
|
BEFREE |
Complete physical mapping of IL6 (using tag SNPs) was carried out for the first time, unveiling allele G of polymorphism rs2069837 (located in the second intron of IL6) as a suggestive marker of protection against chronic periodontitis in a Brazilian population.
|
27172922 |
2017 |
|
rs2069837
|
|
Malignant Neoplasms
|
|
0.010 |
GeneticVariation
|
BEFREE |
IL6 rs2069837 genotype is a clinically relevant prognostic factor in mCRC patients treated with first-line bevacizumab-based chemotherapy.Clin Cancer Res; 22(13); 3218-26.©2016 AACR.
|
26839145 |
2016 |
|
rs2069837
|
|
Secondary malignant neoplasm of colon and/or rectum
|
|
0.010 |
GeneticVariation
|
BEFREE |
IL6 rs2069837 genotype is a clinically relevant prognostic factor in mCRC patients treated with first-line bevacizumab-based chemotherapy.
|
26839145 |
2016 |
|
rs2069837
|
|
Primary malignant neoplasm
|
|
0.010 |
GeneticVariation
|
BEFREE |
IL6 rs2069837 genotype is a clinically relevant prognostic factor in mCRC patients treated with first-line bevacizumab-based chemotherapy.Clin Cancer Res; 22(13); 3218-26.©2016 AACR.
|
26839145 |
2016 |
|
rs2069837
|
|
Neoplasms
|
|
0.010 |
GeneticVariation
|
BEFREE |
Associations between potentially functional IL6 (rs2069837 and rs1800795) and STAT3 (rs744166 and rs4796793) SNPs and clinical outcomes [progression-free survival (PFS), overall survival, and tumor response rate] were evaluated in mCRC patients receiving first-line FOLFIRI plus bevacizumab in two randomized phase III trials: TRIBE (n = 223, training cohort) and FIRE-3 (n = 288, validation cohort).
|
26839145 |
2016 |
|
rs2069837
|
|
Cerebral Palsy
|
|
0.010 |
GeneticVariation
|
BEFREE |
Differences were found between spastic CP and controls in males for rs2069837; between CP with periventricular leukomalacia and controls in males for rs1800796 and rs2066992; and between term CP and controls in males for rs2069837.
|
24903966 |
2014 |
|
rs2069837
|
|
Leukomalacia, Periventricular
|
|
0.010 |
GeneticVariation
|
BEFREE |
Differences were found between spastic CP and controls in males for rs2069837; between CP with periventricular leukomalacia and controls in males for rs1800796 and rs2066992; and between term CP and controls in males for rs2069837.
|
24903966 |
2014 |
|
rs2069837
|
|
Spastic Quadriplegia
|
|
0.010 |
GeneticVariation
|
BEFREE |
However, subgroup analysis found significant differences in allele frequencies between spastic tetraplegia in males compared with controls at rs1800796 (OR=1.39, P=0.033, P=0.099 after SNPSpD correction) and rs2069837 (OR=1.58, P=0.012, P=0.035 after SNPSpD correction).
|
23415255 |
2013 |
|
rs2069837
|
|
Hypertensive disease
|
|
0.010 |
GeneticVariation
|
BEFREE |
Hypertension significantly modified the association between rs2069837 polymorphisms and the risk of LOAD (pinteraction = 0.03).
|
22272811 |
2012 |