|
rs2149356
|
|
Glaucoma, Primary Open Angle
|
|
0.040 |
GeneticVariation
|
BEFREE |
The minor alleles of rs4986791 and rs2149356 within TLR4 gene, interaction between rs2149356 and alcohol drinking were all associated with increased POAG risk.
|
31697008 |
2020 |
|
rs2149356
|
|
Glaucoma, Primary Open Angle
|
|
0.040 |
GeneticVariation
|
BEFREE |
The results revealed that TLR4 rs1927911 A/G, rs12377632 C/T, and rs2149356 G/T significantly decrease the risk of POAG and NTG in allele contrast models 0.71-, 0.71-, and 0.67-fold, respectively.
|
30877182 |
2019 |
|
rs2149356
|
|
Glaucoma, Primary Open Angle
|
|
0.040 |
GeneticVariation
|
BEFREE |
Subjects with genotypes carrying the minor allele of rs1927911 and rs2149356 shown an increased risk for POAG (p = 0.03, OR = 1.78, 95% CI 1.10-2.87, and p < 0.0004, OR =2.62, 95%CI 1.61-4.27 respectively).
|
27892755 |
2017 |
|
rs2149356
|
|
Glaucoma, Primary Open Angle
|
|
0.040 |
GeneticVariation
|
BEFREE |
Other haplotypes, such as rs10759930, rs1927914, rs1927911, and rs2149356, had higher statistical significance (overall P = .00078 in POAG, overall P = .018 in NTG, and overall P = .014 in XFG).
|
22831837 |
2012 |
|
rs2149356
|
|
Low Tension Glaucoma
|
|
0.020 |
GeneticVariation
|
BEFREE |
The results revealed that TLR4 rs1927911 A/G, rs12377632 C/T, and rs2149356 G/T significantly decrease the risk of POAG and NTG in allele contrast models 0.71-, 0.71-, and 0.67-fold, respectively.
|
30877182 |
2019 |
|
rs2149356
|
|
Hepatitis C
|
|
0.020 |
GeneticVariation
|
BEFREE |
<i>In silico</i> analysis of rs2149356G allele showed that this mutation is siRNA, which targets the set of genes, especially in the autophagy pathway.<b>Conclusion:</b> We demonstrated that rs4986790 and rs2149356 are associated with HCV infection.
|
30765614 |
2019 |
|
rs2149356
|
|
Hepatitis C
|
|
0.020 |
GeneticVariation
|
BEFREE |
We conclude that the SNPs TLR4 rs2149356-T/T and IL-10-1082-A/A may be important predictors for HCV therapy.
|
26095186 |
2015 |
|
rs2149356
|
|
Low Tension Glaucoma
|
|
0.020 |
GeneticVariation
|
BEFREE |
With regard to genotypic diversity, individuals with the minor allele of six SNPs (rs10759930, rs1927914, rs1927911, rs12377632, rs2149356, and rs7037117) had a 1.47- to 1.65-fold increased risk of NTG. rs7037117, located in the 3'-untranslated region of TLR4, was most strongly associated with NTG, and when incorporated into a haplotype with rs10759930, the strongest association was detected (P = 0.0038, P(c) = 0.0095).
|
18586872 |
2008 |
|
rs2149356
|
|
Periodontitis
|
|
0.010 |
GeneticVariation
|
BEFREE |
Three SNPs of TLR4, i.e., rs1927911 (TT/CC+CT), rs2149356 (TT/GG+GT) and rs2737190 (GG/AA+AG), were associated with moderate/severe chronic periodontitis in Chinese population infected with <i>P. gingivalis</i>.<i>P. gingivalis</i>, which interacted with TLR4 gene plays an important role in the pathogenesis of periodontitis.
|
31772831 |
2019 |
|
rs2149356
|
|
Chronic Periodontitis
|
|
0.010 |
GeneticVariation
|
BEFREE |
Three SNPs of TLR4, i.e., rs1927911 (TT/CC+CT), rs2149356 (TT/GG+GT) and rs2737190 (GG/AA+AG), were associated with moderate/severe chronic periodontitis in Chinese population infected with <i>P. gingivalis</i>.<i>P. gingivalis</i>, which interacted with TLR4 gene plays an important role in the pathogenesis of periodontitis.
|
31772831 |
2019 |
|
rs2149356
|
|
Hepatitis A
|
|
0.010 |
GeneticVariation
|
BEFREE |
The SNPs within TLR2 [ie, rs1898830 (A>G) and rs3804100 (T>C)], TLR3 [ie, rs1879026 (G>T)], TLR4 [ie, rs2149356 (T>G)], and TLR9 [ie, rs187084 (T>C), rs352139 (A>G), and rs352140 (C>T)] were significantly associated with modified risk of neonatal severe hepatitis (all P<.05).
|
28703296 |
2018 |
|
rs2149356
|
|
Hepatitis
|
|
0.010 |
GeneticVariation
|
BEFREE |
The SNPs within TLR2 [ie, rs1898830 (A>G) and rs3804100 (T>C)], TLR3 [ie, rs1879026 (G>T)], TLR4 [ie, rs2149356 (T>G)], and TLR9 [ie, rs187084 (T>C), rs352139 (A>G), and rs352140 (C>T)] were significantly associated with modified risk of neonatal severe hepatitis (all P<.05).
|
28703296 |
2018 |
|
rs2149356
|
|
Glaucoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
The frequency of the minor allele of rs2149356 was significantly higher in the glaucoma group, conferring an increased risk of POAG (p = 0.0018, OR = 1.803, 95% CI 1.2556-2.5890) whereas minor allele of rs12377632 was significantly lower, attributing a protective effect (p = 0.0001, OR = 0.6662, 95% CI 0.4753-0.9339).
|
27892755 |
2017 |
|
rs2149356
|
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.010 |
GeneticVariation
|
BEFREE |
Single nucleotide polymorphisms (SNPs) in TLR4 (rs1927911, rs11536889, rs1927907, rs1927906, rs1927914, rs7873784, and rs2149356) and TLR2 (rs1898830, rs3804099, rs4696480, and rs3804100) were genotyped in 552 T2DM and 552 unrelated age- and gender-matched controls by SNaPShot Multiplex assay.
|
26345801 |
2015 |
|
rs2149356
|
|
Primary malignant neoplasm
|
|
0.010 |
GeneticVariation
|
BEFREE |
To assess the effect of six selected SNPs (rs1927914, rs4986790, rs4986791, rs11536889, rs1927911 and rs2149356) in TLR4 on cancer, we conducted a meta-analysis, up to February 2012, 22 case-control studies were available.
|
23084080 |
2013 |
|
rs2149356
|
|
Malignant Neoplasms
|
|
0.010 |
GeneticVariation
|
BEFREE |
To assess the effect of six selected SNPs (rs1927914, rs4986790, rs4986791, rs11536889, rs1927911 and rs2149356) in TLR4 on cancer, we conducted a meta-analysis, up to February 2012, 22 case-control studies were available.
|
23084080 |
2013 |
|
rs2149356
|
|
Arthritis, Gouty
|
|
0.010 |
GeneticVariation
|
BEFREE |
The TLR4 gene rs2149356 SNP might be associated with GA susceptibility, and might participate in regulating immune, inflammation and lipid metabolism.
|
23738004 |
2013 |
|
rs2149356
|
|
Liver carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
(1) rs5030719 was monomorphic and was not further analysed; (2) the rs2149356 T allele carrier state was significantly less frequent in patients with HCC than in healthy controls (OR 0.421, 95% CI 0.285-0.625) and in patients with chronic hepatitis C (OR 0.426, 95% CI 0.236-0.767); (3) the proportion of rs2149356 T allele carriers progressively diminished with increasing clinical stage of HCC; (4) no significant differences were observed for the rs4986791 T allele.
|
22286521 |
2012 |
|
rs2149356
|
|
Exfoliation Syndrome
|
|
0.010 |
GeneticVariation
|
BEFREE |
Other haplotypes, such as rs10759930, rs1927914, rs1927911, and rs2149356, had higher statistical significance (overall P = .00078 in POAG, overall P = .018 in NTG, and overall P = .014 in XFG).
|
22831837 |
2012 |