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rs2230774
|
|
Metabolic Syndrome X
|
|
0.010 |
GeneticVariation
|
BEFREE |
In the rs2230774 (Thr431Asn) polymorphism of the ROCK2 gene, there were increases in the CC genotype (16.5%) and C allele frequencies (20.4%) in MetS patients when compared with the control group (CC, 6.0%, p = 0.0009, and C, 6.7%, p < 0.0001).
|
26004609 |
2015 |
|
rs2230774
|
|
Heart Septal Defects
|
|
0.010 |
GeneticVariation
|
BEFREE |
These results suggest that there is no association of the ROCK2 gene Thr431Asn polymorphism with the development of cardiac septal defects in pediatric patients.
|
24668682 |
2014 |
|
rs2230774
|
|
Migraine Disorders
|
|
0.010 |
GeneticVariation
|
BEFREE |
This is the first study to show that the ROCK2 gene Thr431Asn polymorphism is not a risk factor for the migraine in the Turkish population.
|
24608447 |
2014 |
|
rs2230774
|
|
Coronary Artery Disease
|
|
0.010 |
GeneticVariation
|
BEFREE |
Unconditional logistic regression showed that no significant association between common variants in the coding region of ROCK2 and CAD was observed in our study (for rs978906, OR = 0.92, 95% CI 0.72-1.20 and P = 0.63; for rs2230774, OR = 0.90, 95% CI 0.70-1.16 and P = 0.47; for rs56304104, OR = 0.97, 95% CI 0.70-1.31 and P = 0.83; respectively).
|
23326532 |
2013 |
|
rs2230774
|
|
Secondary Neoplasm
|
|
0.010 |
GeneticVariation
|
BEFREE |
Our results demonstrate that Thr431Asn polymorphism of the ROCK2 gene could be a risk factor for the metastases of the breast cancer, and may help in predicting the prognosis.
|
20939434 |
2010 |
|
rs2230774
|
|
Malignant neoplasm of breast
|
|
0.010 |
GeneticVariation
|
BEFREE |
Association between the Thr431Asn polymorphism of the ROCK2 gene and risk of developing metastases of breast cancer.
|
20939434 |
2010 |
|
rs2230774
|
|
Neoplasm Metastasis
|
|
0.010 |
GeneticVariation
|
BEFREE |
Our results demonstrate that Thr431Asn polymorphism of the ROCK2 gene could be a risk factor for the metastases of the breast cancer, and may help in predicting the prognosis.
|
20939434 |
2010 |
|
rs2230774
|
|
Diabetes
|
|
0.010 |
GeneticVariation
|
BEFREE |
These results suggest that there were no evidence for an association of ROCK2 gene Thr431Asn and Arg83Lys polymorphisms with diabetes or diabetic retinopathy in the Turkish population.
|
20961215 |
2010 |
|
rs2230774
|
|
Breast Carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
Association between the Thr431Asn polymorphism of the ROCK2 gene and risk of developing metastases of breast cancer.
|
20939434 |
2010 |
|
rs2230774
|
|
Diabetes Mellitus
|
|
0.010 |
GeneticVariation
|
BEFREE |
These results suggest that there were no evidence for an association of ROCK2 gene Thr431Asn and Arg83Lys polymorphisms with diabetes or diabetic retinopathy in the Turkish population.
|
20961215 |
2010 |
|
rs2230774
|
|
Diabetic Retinopathy
|
|
0.010 |
GeneticVariation
|
BEFREE |
These results suggest that there were no evidence for an association of ROCK2 gene Thr431Asn and Arg83Lys polymorphisms with diabetes or diabetic retinopathy in the Turkish population.
|
20961215 |
2010 |
|
rs2230774
|
|
Chronic Kidney Diseases
|
|
0.010 |
GeneticVariation
|
BEFREE |
The Chi-square test, multivariable logistic regression analysis with adjustment for covariates, and a stepwise forward selection procedure revealed that seven different polymorphisms were significantly (P<0.005) associated with the prevalence of CKD in individuals with low or high serum concentrations of TG or HDL- or LDL-cholesterol: the Aright curved arrow G (Glu23Lys) polymorphism of KCNJ11 and the 125592Cright curved arrow A (Thr431Asn) polymorphism of ROCK2 in individuals with low serum TG; the 734Cright curved arrow T (Thr254Ile) polymorphism of ACAT2 and the Cright curved arrow G (Gln27Glu) polymorphism of ADRB2 in individuals with high serum TG; the -1607/1Gright curved arrow 2G polymorphism of MMP1 in individuals with low serum HDL-cholesterol; the Gright curved arrow A (Val158Met) polymorphism of COMT in individuals with low serum LDL-cholesterol; the 584Gright curved arrow A (Gln192Arg) polymorphism of PON1 in individuals with high serum LDL-cholesterol.
|
19578796 |
2009 |