|
rs2252070
|
|
Aortic Aneurysm, Abdominal
|
|
0.020 |
GeneticVariation
|
BEFREE |
We also assessed the potential association between 2 functional single nucleotide polymorphisms in the genes MMP9 (-1561C/T; rs3918242) and MMP13 (-77A/G; rs2252070), and the presence of large AAAs.
|
29739236 |
2019 |
|
rs2252070
|
|
Aortic Aneurysm, Abdominal
|
|
0.020 |
GeneticVariation
|
BEFREE |
No associations with AAA were identified for other SNPs assessed in this study including rs1799750 (MMP1), rs3918242 (MMP9), rs486055 (MMP10), rs2276109 (MMP12), rs2252070 (MMP13), rs4898 (TIMP1) or rs9619311 (TIMP3).
|
23813847 |
2014 |
|
rs2252070
|
|
Squamous cell carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
In addition, the combined effects of IL-8 (rs4073), MMP-1 (rs2071230 and rs470558) and MMP-13 (rs2252070</span>) with environmental carcinogens, such as tobacco and alcohol, are related to increased risk for oral and oropharyngeal SCC development.
|
31525531 |
2019 |
|
rs2252070
|
|
Osteoarthritis, Knee
|
|
0.010 |
GeneticVariation
|
BEFREE |
The <i>IL-6</i> rs1800795 (-174 G>C) and <i>MMP-13</i> rs2252070 (-77G>A) mutations were associated with KOA susceptibility, increased disease severity, and up-regulation of IL-6 and MMP-13 expression levels.
|
30635366 |
2019 |
|
rs2252070
|
|
Squamous cell carcinoma of esophagus
|
|
0.010 |
GeneticVariation
|
BEFREE |
After analyzing 1588 ESCC patients and frequency-matched 1600 unaffected controls, we found that MMP13 rs2252070 G > A genetic polymorphism is significantly associated with ESCC risk in Chinese Han populations (GA: OR = 0.63, 95% CI = 0.54-0.74, P = 1.7 × 10(-6), AA: OR = 0.73, 95% CI = 0.66-0.81, P = 1.8 × 10(-6)).
|
27245877 |
2016 |
|
rs2252070
|
|
Tendinopathy
|
|
0.010 |
GeneticVariation
|
BEFREE |
One hundred women who presented PTT dysfunction, with histopathological examination of the tendon and magnetic resonance imaging (MRI) confirming tendinopathy, as well as 100 asymptomatic women who presented intact PPT as assessed by MRI and constituting the control group, were evaluated for MMP-13 g.-77 A > G (rs2252070) polymorphism, individually and in haplotypes, as well as in combination with MMP-1 g.-519 A > G (rs1144393), MMP-1 g.-1607 G > GG (rs1799750) and MMP-8 g.-799 C > T (rs11225395) polymorphisms with PTT dysfunction.
|
27886420 |
2016 |
|
rs2252070
|
|
Disorder of tendon
|
|
0.010 |
GeneticVariation
|
BEFREE |
One hundred women who presented PTT dysfunction, with histopathological examination of the tendon and magnetic resonance imaging (MRI) confirming tendinopathy, as well as 100 asymptomatic women who presented intact PPT as assessed by MRI and constituting the control group, were evaluated for MMP-13 g.-77 A > G (rs2252070) polymorphism, individually and in haplotypes, as well as in combination with MMP-1 g.-519 A > G (rs1144393), MMP-1 g.-1607 G > GG (rs1799750) and MMP-8 g.-799 C > T (rs11225395) polymorphisms with PTT dysfunction.
|
27886420 |
2016 |
|
rs2252070
|
|
Extrapulmonary Small Cell Carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
The Sp1-mediaded allelic regulation of MMP13 expression by an ESCC susceptibility SNP rs2252070.
|
27245877 |
2016 |
|
rs2252070
|
|
Primary malignant neoplasm
|
|
0.010 |
GeneticVariation
|
BEFREE |
The results identified a positive association between rs2252070 A>G polymorphism and susceptibility to cancer</span> under five genetic models (all P < 0.05).
|
25023404 |
2014 |
|
rs2252070
|
|
Carcinoma of lung
|
|
0.010 |
GeneticVariation
|
BEFREE |
Our findings suggest significant association for MMP-13 rs2252070 A>G to increased susceptibility to human cancer, especially in the progression of lung carcinoma.
|
25023404 |
2014 |
|
rs2252070
|
|
Malignant Neoplasms
|
|
0.010 |
GeneticVariation
|
BEFREE |
The results identified a positive association between rs2252070 A>G polymorphism and susceptibility to cancer</span> under five genetic models (all P < 0.05).
|
25023404 |
2014 |
|
rs2252070
|
|
Agenesis
|
|
0.010 |
GeneticVariation
|
BEFREE |
We investigated the association between polymorphisms in the MMP2 (rs243865), MMP9 (rs17576), and MMP13 (rs2252070) genes with tooth agenesis in humans.
|
24351915 |
2013 |
|
rs2252070
|
|
Dental caries
|
|
0.010 |
GeneticVariation
|
BEFREE |
The purpose of this study was to determine if polymorphisms in MMP2 (rs243865), MMP9 (rs17576), MMP13 (rs2252070), and TIMP2 (rs7501477) were associated with caries.
|
22710194 |
2012 |
|
rs2252070
|
|
Caries (morphologic abnormality)
|
|
0.010 |
GeneticVariation
|
BEFREE |
The purpose of this study was to determine if polymorphisms in MMP2 (rs243865), MMP9 (rs17576), MMP13 (rs2252070), and TIMP2 (rs7501477) were associated with caries.
|
22710194 |
2012 |