rs2252586
|
|
Glioma
|
|
0.860 |
GeneticVariation
|
BEFREE |
In conclusion, this meta-analysis found that EGFR rs2252586 mutation was significantly associated with glioma risk.
|
29208187 |
2017 |
rs2252586
|
|
Glioma
|
|
0.860 |
GeneticVariation
|
BEFREE |
However, no significant association was observed between rs12718945/rs17172432/rs4947492 and glioma risk in Asians, between rs2252586 and glioma risk in Caucasians, and between rs3752651 and glioma risk in either Asians or Caucasians.
|
29156842 |
2017 |
rs2252586
|
|
Glioma
|
|
0.860 |
GeneticVariation
|
BEFREE |
Results showed that seven hot loci were all associated with increased risk of glioma (rs2736100, OR = 1.28, 95 %CI = 1.23-1.32; rs4295627, OR = 1.34, 95 %CI = 1.21-1.47; rs4977756, OR = 1.24, 95 %CI = 1.20-1.28; rs498872, OR = 1.24, 95 %CI = 1.15-1.33; rs6010620, OR = 1.29, 95 %CI = 1.24-1.35; rs11979158: OR = 1.18, 95 %CI = 1.10-1.25; rs2252586: OR = 1.18, 95 %CI = 1.10-1.25).
|
26243184 |
2016 |
rs2252586
|
|
Glioma
|
|
0.860 |
GeneticVariation
|
BEFREE |
Genome-wide association studies have identified single-nucleotide polymorphisms (SNPs) at 7 loci influencing glioma risk: rs2736100 (TERT), rs11979158 and rs2252586 (EGFR), rs4295627 (CCDC26), rs4977756 (CDKN2A/CDKN2B), rs498872 (PHLDB1), and rs6010620 (RTEL1).
|
23161787 |
2013 |
rs2252586
|
|
Glioma
|
|
0.860 |
GeneticVariation
|
BEFREE |
Seven independent chromosomal loci have robustly been associated with glioma risk: 5p15.33 (rs2736100, TERT), 8q24.21 (rs4295627, CCDC26), 9p21.3 (rs4977756, CDKN2A-CDKN2B), 20q13.33 (rs6010620, RTEL1), and 11q23.3 (rs498872, PHLDB1), and two loci at 7p11.2 (rs11979158 and rs2252586, EGFR).
|
21825990 |
2011 |
rs2252586
|
|
Glioma
|
|
0.860 |
GeneticVariation
|
BEFREE |
Using these data, we demonstrate two statistically independent associations between glioma and rs11979158 and rs2252586, at 7p11.2 which encompasses the EGFR gene (population-corrected statistics, P(c) = 7.72 × 10(-8) and 2.09 × 10(-8), respectively).
|
21531791 |
2011 |
rs2252586
|
|
Malignant Glioma
|
|
0.010 |
GeneticVariation
|
BEFREE |
Similarly, stratified analysis of rs2252586 by stages revealed the similar trend, with OR of 1.26 (95 %CI = 1.17-1.35) in high-grade glioma and OR of 1.15 (95 %CI = 1.08-1.22) in low-grade glioma.
|
26243184 |
2016 |
rs2252586
|
|
High grade glioma
|
|
0.010 |
GeneticVariation
|
BEFREE |
Similarly, stratified analysis of rs2252586 by stages revealed the similar trend, with OR of 1.26 (95 %CI = 1.17-1.35) in high-grade glioma and OR of 1.15 (95 %CI = 1.08-1.22) in low-grade glioma.
|
26243184 |
2016 |
rs2252586
|
|
Neoplasms
|
|
0.010 |
GeneticVariation
|
BEFREE |
In contrast, rs4977756 (CDKN2A/B), rs11979158 (EGFR), and to a lesser extent, rs2252586 (EGFR) risk alleles were independent of tumor grade and genetic profile.
|
23161787 |
2013 |