Source: BEFREE

Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs2296147
rs2296147
CUI: C1306459
Disease: Primary malignant neoplasm
Primary malignant neoplasm
0.050 GeneticVariation BEFREE We evaluated the associations between six single nucleotide polymorphisms (SNPs) in XPG (rs1047768 T>C, rs2296147 T>C, rs2227869 G>C, rs2094258 C>T, rs751402 C>T, and rs873601 G>A) and cancer risk. 28416771

2017

dbSNP: rs2296147
rs2296147
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms
0.050 GeneticVariation BEFREE We evaluated the associations between six single nucleotide polymorphisms (SNPs) in XPG (rs1047768 T>C, rs2296147 T>C, rs2227869 G>C, rs2094258 C>T, rs751402 C>T, and rs873601 G>A) and cancer risk. 28416771

2017

dbSNP: rs2296147
rs2296147
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms
0.050 GeneticVariation BEFREE The moderate effects of rs751402 and rs2296147 polymorphism on cancer susceptibility might be highly dependent on cancer type and ethnicity, respectively. 28796034

2017

dbSNP: rs2296147
rs2296147
CUI: C1306459
Disease: Primary malignant neoplasm
Primary malignant neoplasm
0.050 GeneticVariation BEFREE The moderate effects of rs751402 and rs2296147 polymorphism on cancer susceptibility might be highly dependent on cancer type and ethnicity, respectively. 28796034

2017

dbSNP: rs2296147
rs2296147
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms
0.050 GeneticVariation BEFREE This meta-analysis aimed to evaluate the reliable predictive value of XPG rs2296147T>C polymorphism on clinical outcomes of cancer patients. 27588464

2016

dbSNP: rs2296147
rs2296147
CUI: C1306459
Disease: Primary malignant neoplasm
Primary malignant neoplasm
0.050 GeneticVariation BEFREE This meta-analysis aimed to evaluate the reliable predictive value of XPG rs2296147T>C polymorphism on clinical outcomes of cancer patients. 27588464

2016

dbSNP: rs2296147
rs2296147
CUI: C1306459
Disease: Primary malignant neoplasm
Primary malignant neoplasm
0.050 GeneticVariation BEFREE The combination genotype of XPG rs2296147 T and CSB rs2228526 G allele had accumulative effect on the risk of this cancer, with an OR (95% CI) of 2.23(1.37-3.59). 24289586

2013

dbSNP: rs2296147
rs2296147
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms
0.050 GeneticVariation BEFREE The combination genotype of XPG rs2296147 T and CSB rs2228526 G allele had accumulative effect on the risk of this cancer, with an OR (95% CI) of 2.23(1.37-3.59). 24289586

2013

dbSNP: rs2296147
rs2296147
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms
0.050 GeneticVariation BEFREE Our results showed that rs751402 were associated with increased GC risk (AA vs. GG: OR=1.99, 95%CI: 1.20-3.31, P=0.008; AG+AA vs. GG: OR=1.41, 95%CI: 1.07-1.86, P=0.016), and rs2296147 was also associated with increased cancer risk (CC vs. TT: OR=2.17, 95%CI: 1.04-4.54, P=0.039; CC vs. CT+TT: OR=2.26, 95%CI: 1.09-4.69, P=0.028). 22982416

2012

dbSNP: rs2296147
rs2296147
CUI: C1306459
Disease: Primary malignant neoplasm
Primary malignant neoplasm
0.050 GeneticVariation BEFREE Our results showed that rs751402 were associated with increased GC risk (AA vs. GG: OR=1.99, 95%CI: 1.20-3.31, P=0.008; AG+AA vs. GG: OR=1.41, 95%CI: 1.07-1.86, P=0.016), and rs2296147 was also associated with increased cancer risk (CC vs. TT: OR=2.17, 95%CI: 1.04-4.54, P=0.039; CC vs. CT+TT: OR=2.26, 95%CI: 1.09-4.69, P=0.028). 22982416

2012

dbSNP: rs2296147
rs2296147
CUI: C0268141
Disease: Xeroderma pigmentosum, group G
Xeroderma pigmentosum, group G
0.040 GeneticVariation BEFREE Odds ratio (OR) and 95% confidence interval (CI) were used to assess the association between XPG polymorphisms (rs751402, rs873601, and rs2296147) and cancer risk. 28796034

2017

dbSNP: rs2296147
rs2296147
CUI: C0268141
Disease: Xeroderma pigmentosum, group G
Xeroderma pigmentosum, group G
0.040 GeneticVariation BEFREE We evaluated the associations between six single nucleotide polymorphisms (SNPs) in XPG (rs1047768 T>C, rs2296147 T>C, rs2227869 G>C, rs2094258 C>T, rs751402 C>T, and rs873601 G>A) and cancer risk. 28416771

2017

dbSNP: rs2296147
rs2296147
CUI: C0268141
Disease: Xeroderma pigmentosum, group G
Xeroderma pigmentosum, group G
0.040 GeneticVariation BEFREE XPG rs2296147 polymorphism could be predictive of unfavorable prognosis of CRC patients. 26887052

2016

dbSNP: rs2296147
rs2296147
CUI: C0268141
Disease: Xeroderma pigmentosum, group G
Xeroderma pigmentosum, group G
0.040 GeneticVariation BEFREE The XPG rs2296147T>C polymorphism might be a predictive factor of prognosis in cancers patients and contribute to individual treatment in the future. 27588464

2016

dbSNP: rs2296147
rs2296147
CUI: C0699791
Disease: Stomach Carcinoma
Stomach Carcinoma
0.030 GeneticVariation BEFREE None of the examined loci were statistically associated with GC risk, although rs2296147 was marginally associated with GC risk (<i>P</i> = 0.050). 31558863

2019

dbSNP: rs2296147
rs2296147
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.030 GeneticVariation BEFREE None of the examined loci were statistically associated with GC risk, although rs2296147 was marginally associated with GC risk (<i>P</i> = 0.050). 31558863

2019

dbSNP: rs2296147
rs2296147
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.030 GeneticVariation BEFREE We performed this hospital-based case-control study to evaluate the association of four potentially functional XPG polymorphisms (rs2094258 C>T, rs751402 C>T, rs2296147 T>C and rs873601G>A) with stomach cancer susceptibility. 26820236

2016

dbSNP: rs2296147
rs2296147
CUI: C0699791
Disease: Stomach Carcinoma
Stomach Carcinoma
0.030 GeneticVariation BEFREE We performed this hospital-based case-control study to evaluate the association of four potentially functional XPG polymorphisms (rs2094258 C>T, rs751402 C>T, rs2296147 T>C and rs873601G>A) with stomach cancer susceptibility. 26820236

2016

dbSNP: rs2296147
rs2296147
CUI: C0699791
Disease: Stomach Carcinoma
Stomach Carcinoma
0.030 GeneticVariation BEFREE Genetic effects on increased GC risk seemed to be enhanced by Helicobacter pylori infection, smoking and alcohol drinking, with corresponding adjusted ORs of 4.57, 2.42 and 2.50 for the rs751402 AG/AA variants, and of 5.32, 3.20 and 6.87 for the rs2296147 CC variant, but their interaction effects on GC risk didn't reach statistically significance. 22982416

2012

dbSNP: rs2296147
rs2296147
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.030 GeneticVariation BEFREE Genetic effects on increased GC risk seemed to be enhanced by Helicobacter pylori infection, smoking and alcohol drinking, with corresponding adjusted ORs of 4.57, 2.42 and 2.50 for the rs751402 AG/AA variants, and of 5.32, 3.20 and 6.87 for the rs2296147 CC variant, but their interaction effects on GC risk didn't reach statistically significance. 22982416

2012

dbSNP: rs2296147
rs2296147
CUI: C0007131
Disease: Non-Small Cell Lung Carcinoma
Non-Small Cell Lung Carcinoma
0.020 GeneticVariation BEFREE In the Cox proportional hazard model, patients carrying the rs2296147 TT genotype and the T allele had a significantly reduced risk of developing progressive disease or dying from NSCLC. 25729984

2015

dbSNP: rs2296147
rs2296147
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate
0.020 GeneticVariation BEFREE In conclusion, we found that polymorphisms in XPG rs2296147 and CSB rs2228526 were significantly associated with prostate cancer susceptibility in the Chinese population analyzed. 24615090

2014

dbSNP: rs2296147
rs2296147
CUI: C0600139
Disease: Prostate carcinoma
Prostate carcinoma
0.020 GeneticVariation BEFREE In conclusion, we found that polymorphisms in XPG rs2296147 and CSB rs2228526 were significantly associated with prostate cancer susceptibility in the Chinese population analyzed. 24615090

2014

dbSNP: rs2296147
rs2296147
CUI: C0600139
Disease: Prostate carcinoma
Prostate carcinoma
0.020 GeneticVariation BEFREE Our study indicates that XPG rs2296147 and CSB rs2228526 polymorphisms are significantly associated with increased risk of prostate cancer, and that combination of XPG rs2296147 T allele and CSB rs2228526 G allele is strongly associated with an increased risk. 24289586

2013

dbSNP: rs2296147
rs2296147
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate
0.020 GeneticVariation BEFREE Our study indicates that XPG rs2296147 and CSB rs2228526 polymorphisms are significantly associated with increased risk of prostate cancer, and that combination of XPG rs2296147 T allele and CSB rs2228526 G allele is strongly associated with an increased risk. 24289586

2013