|
rs2383207
|
|
Myocardial Infarction
|
|
0.770 |
GeneticVariation
|
BEFREE |
Genome-wide association studies have identified 2 single-nucleotide polymorphisms (SNPs) on chromosome arm 9p21, rs10757278, and rs2383207 that confer susceptibility to myocardial infarction.
|
23454037 |
2013 |
|
rs2383207
|
|
Myocardial Infarction
|
|
0.770 |
GeneticVariation
|
BEFREE |
The CDKN2A/B locus (rs2383207, 9p21), identified initially as a susceptibility allele for MI and recently implicated in large vessel stroke, was associated with macroscopic infarct pathology in our autopsy cohort (OR = 1.26, p = 0.031).
|
24135527 |
2013 |
|
rs2383207
|
|
Myocardial Infarction
|
|
0.770 |
GeneticVariation
|
BEFREE |
Subjects with the rs2383207 GG genotype had a 1.85-fold (P = 0.021) risk for MI when compared with the subjects with the AA genotype.
|
21415773 |
2011 |
|
rs2383207
|
|
Myocardial Infarction
|
|
0.770 |
GeneticVariation
|
BEFREE |
Background Two single nucleotide polymorphisms (SNPs, rs10757278 and rs2383207) on chromosome 9p21 have been proved to be associated with myocardial infarction.
|
18459066 |
2009 |
|
rs2383207
|
|
Myocardial Infarction
|
|
0.770 |
GeneticVariation
|
BEFREE |
We related SNPs rs2383207 and rs10757278 to stroke and to myocardial infarction and coronary revascularizations (coronary events) using crude and multivariate adjusted Cox proportional hazards models.
|
19293724 |
2009 |
|
rs2383207
|
|
Myocardial Infarction
|
|
0.770 |
GeneticVariation
|
BEFREE |
Genome-wide single nucleotide polymorphism (SNP) association studies recently identified four SNPs (rs10757274, rs2383206, rs2383207, and rs10757278) on chromosome 9p21 that were associated with coronary artery disease (CAD) and myocardial infarction (MI) in Caucasian populations from northern Europe and North America.
|
18066490 |
2008 |
|
rs2383207
|
|
Myocardial Infarction
|
|
0.770 |
GeneticVariation
|
BEFREE |
Recent genome-wide association studies have identified 4 SNPs on chromosome 9p21 associated with CAD (rs10757274 and rs2383206) and myocardial infarction (MI: rs2383207 and rs10757278) in White populations in Northern Europe and North America.
|
18048766 |
2008 |
|
rs2383207
|
|
Coronary Artery Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
Further subgroup analyses showed that rs1333040, rs1333049 and rs2383207 polymorphisms were significantly correlated with the risk of CAD in East Asians, rs2383206 and rs10757274 polymorphisms were significantly correlated with the risk of CAD in West Asians, while rs2383206, rs10757274 and rs10757278 polymorphisms were significantly correlated with the risk of CAD in Caucasians.
|
30814313 |
2019 |
|
rs2383207
|
|
Coronary Artery Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
Pooled overall analyses showed that rs1333040 (dominant model: P < 0.0001; recessive model: P < 0.0001; allele model: P < 0.0001), rs1333049 (dominant model: P = 0.02; allele model: P = 0.02) and rs2383207 (additive model: P = 0.004; allele model: P = 0.03) polymorphisms were significantly associated with the likelihood of CAD.
|
30387168 |
2019 |
|
rs2383207
|
|
Coronary Artery Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
The polymorphic variants of Apo-A5; rs2266788 (C), 9p21.3; rs1333049 (C) rs2383207 (A) are associated with CAD, its severity and exerts the risk of MI in North Indian population.
|
29309886 |
2018 |
|
rs2383207
|
|
Coronary Artery Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
In conclusion, this meta-analysis suggested that ANRIL rs2383207 polymorphism is associated with CAD risk.
|
27894414 |
2016 |
|
rs2383207
|
|
Coronary Artery Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
The risk allele G of rs2383207 was associated with severity of CAD estimated by the Gensini score (P = 3.6×10(-5) ).
|
27461153 |
2016 |
|
rs2383207
|
|
Coronary Artery Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
The rs2383207 and rs1333049 SNPs on 9p21 chromosome were significantly associated with the risk and severity of CAD in the Turkish population.
|
25333979 |
2015 |
|
rs2383207
|
|
Coronary Artery Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
We identified two 9p21.3-variants, rs4977574 (P < 4×10(-4)) and rs2383207 (P < 1.5×10(-3)) that were associated with severity of CAD in subjects without T2D.
|
23343465 |
2013 |
|
rs2383207
|
|
Coronary Artery Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
Further, we evaluated nine additional SNPs, of which two SNPs flanking rs2383207 (rs1537375 [p = 2.4 × 10(-5)] and rs1537374 [p = 5.6 × 10(-5)]) were also strongly associated with CAD.
|
20858033 |
2011 |
|
rs2383207
|
|
Coronary Artery Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
Conclusions The rs10757278 and rs2383207 variants are determinants for early-onset coronary artery disease.
|
18459066 |
2009 |
|
rs2383207
|
|
Coronary Artery Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
Genome-wide single nucleotide polymorphism (SNP) association studies recently identified four SNPs (rs10757274, rs2383206, rs2383207, and rs10757278) on chromosome 9p21 that were associated with coronary artery disease (CAD) and myocardial infarction (MI) in Caucasian populations from northern Europe and North America.
|
18066490 |
2008 |
|
rs2383207
|
|
Ischemic stroke
|
|
0.040 |
GeneticVariation
|
BEFREE |
There was no association between clinical severity and recurrence with variants rs2383207 (CDKN2B-AS1) for atherothrombotic IS and variants rs879324 (ZFHX3), rs966221 (PDE4D), and rs152312 (PDE4D) for cardioembolic IS.
|
31757599 |
2020 |
|
rs2383207
|
|
Coronary heart disease
|
|
0.040 |
GeneticVariation
|
BEFREE |
The association of polymorphic variants, rs2267788, rs1333049 and rs2383207 with coronary artery disease, its severity and presentation in North Indian population.
|
29309886 |
2018 |
|
rs2383207
|
|
Ischemic stroke
|
|
0.040 |
GeneticVariation
|
BEFREE |
The ANRIL variants rs2383207 and rs1333049 were significantly associated with the risk of IS among males but not females in the Chinese Han population.
|
29881905 |
2018 |
|
rs2383207
|
|
Ischemic stroke
|
|
0.040 |
GeneticVariation
|
BEFREE |
CDKN2A/CDKN2B SNP rs2383207 is independently associated with ischemic stroke in indigenous West African men.
|
28716248 |
2017 |
|
rs2383207
|
|
Coronary heart disease
|
|
0.040 |
GeneticVariation
|
BEFREE |
Some studies investigated the association of antisense non-coding RNA in the INK4 locus (ANRIL) rs2383207 polymorphism with coronary artery disease (CAD) risk.
|
27894414 |
2016 |
|
rs2383207
|
|
Ischemic stroke
|
|
0.040 |
GeneticVariation
|
BEFREE |
Chromosome 9p21 SNPs were also associated with risk of ischaemic stroke in African Americans (rs1333040, OR 0.65, P = 0.023; rs1333042, OR 0.55, P = 0.070; rs2383207, OR 0.55, P = 0.070).
|
22882272 |
2013 |
|
rs2383207
|
|
Coronary heart disease
|
|
0.040 |
GeneticVariation
|
BEFREE |
Conclusions The rs10757278 and rs2383207 variants are determinants for early-onset coronary artery disease.
|
18459066 |
2009 |
|
rs2383207
|
|
Coronary heart disease
|
|
0.040 |
GeneticVariation
|
BEFREE |
The SNP rs2383207 on chromosome 9p21 is significantly associated with CHD in Chinese.
|
18757290 |
2008 |