rs4073
|
|
Malignant neoplasm of prostate
|
|
0.050 |
GeneticVariation
|
BEFREE |
The frequency of the A allele of the rs4073 was significantly lower in PCa group compared with BPH group (OR (95% CI) = 0.62 (0.46-0.84), adjusted P value = 0.006).
|
30641210 |
2019 |
rs4073
|
|
Malignant neoplasm of prostate
|
|
0.050 |
GeneticVariation
|
BEFREE |
The major findings of this meta-analysis suggested that IL-8 rs4073 polymorphism is significantly associated with risk of prostate cancer.
|
31718853 |
2019 |
rs4073
|
|
Prostate carcinoma
|
|
0.050 |
GeneticVariation
|
BEFREE |
The frequency of the A allele of the rs4073 was significantly lower in PCa group compared with BPH group (OR (95% CI) = 0.62 (0.46-0.84), adjusted P value = 0.006).
|
30641210 |
2019 |
rs4073
|
|
Prostate carcinoma
|
|
0.050 |
GeneticVariation
|
BEFREE |
The major findings of this meta-analysis suggested that IL-8 rs4073 polymorphism is significantly associated with risk of prostate cancer.
|
31718853 |
2019 |
rs4073
|
|
Malignant neoplasm of prostate
|
|
0.050 |
GeneticVariation
|
BEFREE |
Minor alleles of rs2243250 (T) in IL4 (OR = 1.46, 95% CI 1.03-2.08, P-trend = 0.03), rs1800896 (G) in IL10 (OR = 0.77, 95% CI 0.61-0.96, P-trend = 0.02), rs2430561 (A) in IFNG (OR = 1.33, 95% CI 1.02-1.74; P-trend = 0.04), rs3747531 (C) in MSR1 (OR = 0.55, 95% CI 0.32-0.95; P-trend = 0.03), and possibly rs4073 (A) in IL8 (OR = 0.81, 95% CI 0.64-1.01, P-trend = 0.06) were associated with higher- (Gleason 7-10; N = 222), but not lower- (Gleason 2-6; N = 380) grade prostate cancer.
|
28317149 |
2017 |
rs4073
|
|
Prostate carcinoma
|
|
0.050 |
GeneticVariation
|
BEFREE |
Minor alleles of rs2243250 (T) in IL4 (OR = 1.46, 95% CI 1.03-2.08, P-trend = 0.03), rs1800896 (G) in IL10 (OR = 0.77, 95% CI 0.61-0.96, P-trend = 0.02), rs2430561 (A) in IFNG (OR = 1.33, 95% CI 1.02-1.74; P-trend = 0.04), rs3747531 (C) in MSR1 (OR = 0.55, 95% CI 0.32-0.95; P-trend = 0.03), and possibly rs4073 (A) in IL8 (OR = 0.81, 95% CI 0.64-1.01, P-trend = 0.06) were associated with higher- (Gleason 7-10; N = 222), but not lower- (Gleason 2-6; N = 380) grade prostate cancer.
|
28317149 |
2017 |
rs4073
|
|
Prostate carcinoma
|
|
0.050 |
GeneticVariation
|
BEFREE |
The purpose of this study was to evaluate the relationship between single-nucleotide polymorphism (SNP) rs2228001 in xeroderma pigmentosum group C (XPC), SNP rs4073 in interleukin 8 (IL8), and SNP rs2279744 in mouse double minute 2 (MDM2) homolog gene with PCa susceptibility.
|
26135929 |
2015 |
rs4073
|
|
Malignant neoplasm of prostate
|
|
0.050 |
GeneticVariation
|
BEFREE |
The purpose of this study was to evaluate the relationship between single-nucleotide polymorphism (SNP) rs2228001 in xeroderma pigmentosum group C (XPC), SNP rs4073 in interleukin 8 (IL8), and SNP rs2279744 in mouse double minute 2 (MDM2) homolog gene with PCa susceptibility.
|
26135929 |
2015 |
rs4073
|
|
Prostate carcinoma
|
|
0.050 |
GeneticVariation
|
BEFREE |
After adjustment for confounders, polymorphisms in COX-2 (rs689466) and IL-8 (rs4073) were not significantly associated with prostate cancer risk.
|
20431935 |
2010 |
rs4073
|
|
Malignant neoplasm of prostate
|
|
0.050 |
GeneticVariation
|
BEFREE |
After adjustment for confounders, polymorphisms in COX-2 (rs689466) and IL-8 (rs4073) were not significantly associated with prostate cancer risk.
|
20431935 |
2010 |
rs4073
|
|
Tuberculosis
|
|
0.040 |
GeneticVariation
|
BEFREE |
IL-2 rs2069762 (recessive comparison), IL-4 rs2243250 (recessive and allele comparisons), IL-6 rs1800795 (dominant, recessive and allele comparisons), IL-8 rs4073 (dominant, recessive and allele comparisons), IL-10 rs1800871 (dominant, recessive and allele comparisons) and IL-10 rs1800896 (recessive comparison) polymorphisms were all significantly associated with TB in the total population.
|
31669382 |
2020 |
rs4073
|
|
Coronary Artery Disease
|
|
0.040 |
GeneticVariation
|
BEFREE |
Association of IL-8-251 A/T rs4073 and IL-10 rs1800872 -592C/A Polymorphisms and Coronary Artery Disease in North Indian Population.
|
30073578 |
2019 |
rs4073
|
|
Tuberculosis
|
|
0.040 |
GeneticVariation
|
BEFREE |
Collectively, this meta-analysis proved that IL-6 rs1800795, IL-8 rs4073, IL-10 rs1800871, IL-10 rs1800872 and IL-10 rs1800896 may confer susceptibility to TB.
|
31560754 |
2019 |
rs4073
|
|
Coronary Artery Disease
|
|
0.040 |
GeneticVariation
|
BEFREE |
Interleukin-8 Gene -251 A/T (rs4073) Polymorphism and Coronary Artery Disease Risk: A Meta-Analysis.
|
30826813 |
2019 |
rs4073
|
|
Malignant neoplasm of stomach
|
|
0.040 |
GeneticVariation
|
BEFREE |
Significant associations with the risk of gastric cancer were only detected for the IL-8 rs4073 polymorphism in overall analyses.
|
30195978 |
2018 |
rs4073
|
|
Malignant neoplasm of stomach
|
|
0.040 |
GeneticVariation
|
BEFREE |
Further subgroup analyses based on ethnicities of participants revealed that the IL-4 rs2</span>243250, IL-6 rs1800796 and IL-8 rs4073 polymorphisms were significantly associated with the risk of GC in Asians.
|
30071135 |
2018 |
rs4073
|
|
Stomach Carcinoma
|
|
0.040 |
GeneticVariation
|
BEFREE |
Significant associations with the risk of gastric cancer were only detected for the IL-8 rs4073 polymorphism in overall analyses.
|
30195978 |
2018 |
rs4073
|
|
Stomach Carcinoma
|
|
0.040 |
GeneticVariation
|
BEFREE |
Further subgroup analyses based on ethnicities of participants revealed that the IL-4 rs2</span>243250, IL-6 rs1800796 and IL-8 rs4073 polymorphisms were significantly associated with the risk of GC in Asians.
|
30071135 |
2018 |
rs4073
|
|
Coronary Artery Disease
|
|
0.040 |
GeneticVariation
|
BEFREE |
We conducted an investigation to assess the relationship between the IL-8 -251A/T (rs4073) sequence variant and CAD in a Chinese population.
|
28218776 |
2017 |
rs4073
|
|
Tuberculosis
|
|
0.040 |
GeneticVariation
|
BEFREE |
Secretion of IL8 by peripheral blood cells was greatly stimulated upon exposure to Mycobacterium tuberculosis whole cell extract, but such enhanced secretion was not associated with the IL8 rs4073 alleles.
|
27003175 |
2016 |
rs4073
|
|
Malignant neoplasm of stomach
|
|
0.040 |
GeneticVariation
|
BEFREE |
The goal of this study was to evaluate the influence that polymorphisms in the cytokine genes known as TNF-α-308 G/A (rs1800629), TNF-α-857 C/T (rs1799724), IL-8-251 T/A (rs4073), IL-8-845 T/C (rs2227532), and IL-10-592 C/A (rs1800872) have on changes to mRNA expression levels and on the risks of chronic gastritis (CG) and gastric cancer (GC).
|
26088449 |
2015 |
rs4073
|
|
Stomach Carcinoma
|
|
0.040 |
GeneticVariation
|
BEFREE |
The goal of this study was to evaluate the influence that polymorphisms in the cytokine genes known as TNF-α-308 G/A (rs1800629), TNF-α-857 C/T (rs1799724), IL-8-251 T/A (rs4073), IL-8-845 T/C (rs2227532), and IL-10-592 C/A (rs1800872) have on changes to mRNA expression levels and on the risks of chronic gastritis (CG) and gastric cancer (GC).
|
26088449 |
2015 |
rs4073
|
|
Coronary Artery Disease
|
|
0.040 |
GeneticVariation
|
BEFREE |
We conducted a case-control study to investigate the genetic variants Interleukin-1β(IL-1β) +3953 C/T (rs1143634), IL-6 -174G/C (rs1800795), IL-8 -251T/A (rs4073), and IL-10 -1082A/G (rs1800896) and -819C/T (rs1800871) in the development of coronary artery disease (CAD).
|
26505399 |
2015 |
rs4073
|
|
Tuberculosis
|
|
0.040 |
GeneticVariation
|
BEFREE |
A higher prevalence of purified protein derivative reactivity was associated with the TNF-α CCA/TCG haplotype (PR 1.298, 95%CI 1.059-1.589) and with the IL-10 AT/CC diplotype (PR 1.181, 95% CI 1.024-1.362), and the presence of the IL-8 rs4073 T allele was associated with protection against TB (PR 0.482, 95%CI 0.273-0.851).
|
25199010 |
2014 |
rs4073
|
|
Stomach Carcinoma
|
|
0.040 |
GeneticVariation
|
BEFREE |
The aim of this study was to investigate the association between the IL-8 (rs4073) -251A/T gene polymorphism and the risk of gastric cancer (GC).
|
23558993 |
2012 |