|
rs4746
|
|
Breast Carcinoma
|
|
0.030 |
GeneticVariation
|
BEFREE |
Glyoxalase I Ala111Glu gene polymorphism: No association with breast cancer risk but correlated with absence of progesterone receptor.
|
20712647 |
2010 |
|
rs4746
|
|
Malignant neoplasm of breast
|
|
0.030 |
GeneticVariation
|
BEFREE |
Glyoxalase I Ala111Glu gene polymorphism: No association with breast cancer risk but correlated with absence of progesterone receptor.
|
20712647 |
2010 |
|
rs4746
|
|
Malignant neoplasm of breast
|
|
0.030 |
GeneticVariation
|
BEFREE |
In the present case-control study, we investigated the possible association of CYP17 A1A2, GSTP1 ILE105VAL, PON1 Q192R or L55M, and GLO1 A111E polymorphisms with the risk of BC.
|
19379515 |
2009 |
|
rs4746
|
|
Breast Carcinoma
|
|
0.030 |
GeneticVariation
|
BEFREE |
Glyoxalase I Glu111Ala polymorphism in patients with breast cancer.
|
19452310 |
2009 |
|
rs4746
|
|
Malignant neoplasm of breast
|
|
0.030 |
GeneticVariation
|
BEFREE |
Glyoxalase I Glu111Ala polymorphism in patients with breast cancer.
|
19452310 |
2009 |
|
rs4746
|
|
Breast Carcinoma
|
|
0.030 |
GeneticVariation
|
BEFREE |
In the present case-control study, we investigated the possible association of CYP17 A1A2, GSTP1 ILE105VAL, PON1 Q192R or L55M, and GLO1 A111E polymorphisms with the risk of BC.
|
19379515 |
2009 |
|
rs4746
|
|
Autistic Disorder
|
|
0.020 |
GeneticVariation
|
BEFREE |
A family-based association study involving 385 simplex and 20 multiplex Italian families yielded a significant association with autism driven only by the rs4746 C332 (Ala111) allele itself (P < 0.05 and P < 0.001 under additive and dominant/recessive models, respectively).
|
25201284 |
2014 |
|
rs4746
|
|
Autistic Disorder
|
|
0.020 |
GeneticVariation
|
BEFREE |
Glyoxalase I polymorphism rs2736654 causing the Ala111Glu substitution modulates enzyme activity--implications for autism.
|
21491613 |
2011 |
|
rs4746
|
|
Huntington Disease
|
|
0.020 |
GeneticVariation
|
BEFREE |
The A419C (E111A) polymorphism of the GLO I gene is associated with vascular disease in hemodialysis (HD) patients and some RAGE gene polymorphisms are implicated in various pathological states.
|
20185929 |
2010 |
|
rs4746
|
|
Hodgkin Disease
|
|
0.020 |
GeneticVariation
|
BEFREE |
The A419C (E111A) polymorphism of the GLO I gene is associated with vascular disease in hemodialysis (HD) patients and some RAGE gene polymorphisms are implicated in various pathological states.
|
20185929 |
2010 |
|
rs4746
|
|
Hodgkin Disease
|
|
0.020 |
GeneticVariation
|
BEFREE |
Our aim was to study A419C (E111A) single nucleotide polymorphism (SNP) of the glyoxalase I gene in hemodialysis (HD) patients.
|
18079478 |
2008 |
|
rs4746
|
|
Huntington Disease
|
|
0.020 |
GeneticVariation
|
BEFREE |
Our aim was to study A419C (E111A) single nucleotide polymorphism (SNP) of the glyoxalase I gene in hemodialysis (HD) patients.
|
18079478 |
2008 |
|
rs4746
|
|
Drug Resistant Epilepsy
|
|
0.010 |
GeneticVariation
|
BEFREE |
Further analyses in cohort I+II indicate that the presence of the TAC/AAT haplotypes (rs1130534-rs4746-rs1049346) may be used as a marker of predisposition to/protection against DRE (p=0.002, q=0.010; p=0.000, q=0.002, respectively).
|
27000251 |
2016 |
|
rs4746
|
|
Neoplasms
|
|
0.010 |
GeneticVariation
|
BEFREE |
Our results demonstrate the link of E111A GLO1 SNP to the presence of the tumor and the connection of RAGE -429T/C and 2184A/G SNPs with the aggressiveness of the tumor.
|
25407489 |
2015 |
|
rs4746
|
|
Cavernous Hemangioma of Brain
|
|
0.010 |
GeneticVariation
|
BEFREE |
The present study aimed to investigate the possible association of GLO1 A111E, PON1 Q192R and L55M polymorphisms with the risk of CCMs.
|
26122242 |
2015 |
|
rs4746
|
|
Restless Legs Syndrome
|
|
0.010 |
GeneticVariation
|
BEFREE |
The GLO1 p.E111A variant was associated with RLS in the French-Canadian cohort (odds ratio, OR = 1.38, p = 0.02), and demonstrated a similar trend in the US cohort (OR = 1.26, p = 0.09, combined analysis OR = 1.28, p = 0.009).
|
26298793 |
2015 |
|
rs4746
|
|
Autism Spectrum Disorders
|
|
0.010 |
GeneticVariation
|
BEFREE |
We previously found the rs4746 A332 (Glu111) allele of the GLO1 gene, which encodes for glyoxalase I, associated with "unaffected sibling" status in families with one or more children affected by Autism Spectrum Disorder (ASD).
|
25201284 |
2014 |
|
rs4746
|
|
Endothelial dysfunction
|
|
0.010 |
GeneticVariation
|
BEFREE |
The aim of our study was to evaluate an association of FN3K (rs1056534, rs3848403) and GLO1 rs4746 polymorphisms with parameters of endothelial dysfunction and soluble receptor for AGEs (sRAGE) in 595 diabetic and non-diabetic subjects.
|
24908234 |
2014 |
|
rs4746
|
|
Diabetes
|
|
0.010 |
GeneticVariation
|
BEFREE |
In a multiple regression analysis with GLO1 activity as the dependent variable, including the Ala111Glu polymorphism, the significant independent variables were log GSSG (ß - 0.318, p = 0.02) and HbA1c (ß 0.285, p = 0.041) in the diabetes group and log GSH, (ß 0.407, p = 0.004) in the control group.
|
23360186 |
2013 |
|
rs4746
|
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.010 |
GeneticVariation
|
BEFREE |
Here, we examine a possible association of a single nucleotide polymorphism of glyoxalase 1 gene (Glo1 A332C, rs4746 or rs2736654) with the prevalence of microvascular diabetic complications in patients with type 1 and type 2 diabetes.
|
23775136 |
2013 |
|
rs4746
|
|
Complications of Diabetes Mellitus
|
|
0.010 |
GeneticVariation
|
BEFREE |
Here, we examine a possible association of a single nucleotide polymorphism of glyoxalase 1 gene (Glo1 A332C, rs4746 or rs2736654) with the prevalence of microvascular diabetic complications in patients with type 1 and type 2 diabetes.
|
23775136 |
2013 |
|
rs4746
|
|
Diabetes Mellitus, Insulin-Dependent
|
|
0.010 |
GeneticVariation
|
BEFREE |
Glyoxalase 1 enzyme activity in erythrocytes and Ala111Glu polymorphism in type 1-diabetes patients.
|
23360186 |
2013 |
|
rs4746
|
|
Diabetes Mellitus
|
|
0.010 |
GeneticVariation
|
BEFREE |
In a multiple regression analysis with GLO1 activity as the dependent variable, including the Ala111Glu polymorphism, the significant independent variables were log GSSG (ß - 0.318, p = 0.02) and HbA1c (ß 0.285, p = 0.041) in the diabetes group and log GSH, (ß 0.407, p = 0.004) in the control group.
|
23360186 |
2013 |
|
rs4746
|
|
Malignant Neoplasms
|
|
0.010 |
GeneticVariation
|
BEFREE |
Effect of advanced glycation end products (AGEs) in the pathogenesis of cancer could be diminished by interaction with soluble RAGE or by reducing AGE-precursors via glyoxalase I. Glu111Ala polymorphism of glyoxalase I gene, AGEs, and sRAGE serum levels were studied in 113 breast cancer patients and in 58 controls.
|
19452310 |
2009 |
|
rs4746
|
|
Primary malignant neoplasm
|
|
0.010 |
GeneticVariation
|
BEFREE |
Effect of advanced glycation end products (AGEs) in the pathogenesis of cancer could be diminished by interaction with soluble RAGE or by reducing AGE-precursors via glyoxalase I. Glu111Ala polymorphism of glyoxalase I gene, AGEs, and sRAGE serum levels were studied in 113 breast cancer patients and in 58 controls.
|
19452310 |
2009 |