Source: ALL

Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs651821
rs651821
APOA5
CUI: C0392885
Disease: High density lipoprotein measurement
High density lipoprotein measurement 		0.800 GeneticVariation GWASCAT Genetic analyses of diverse populations improves discovery for complex traits. 31217584

2019
dbSNP: rs651821
rs651821
APOA5
CUI: C0202236
Disease: Triglycerides measurement
Triglycerides measurement 		C 0.800 GeneticVariation GWASCAT The Korea Biobank Array: Design and Identification of Coding Variants Associated with Blood Biochemical Traits. 30718733

2019
dbSNP: rs651821
rs651821
APOA5
CUI: C1445957
Disease: Serum total cholesterol measurement
Serum total cholesterol measurement 		0.800 GeneticVariation GWASCAT Genetic analyses of diverse populations improves discovery for complex traits. 31217584

2019
dbSNP: rs651821
rs651821
APOA5
CUI: C0202236
Disease: Triglycerides measurement
Triglycerides measurement 		0.800 GeneticVariation GWASCAT Genetic analyses of diverse populations improves discovery for complex traits. 31217584

2019
dbSNP: rs651821
rs651821
APOA5
CUI: C0202236
Disease: Triglycerides measurement
Triglycerides measurement 		0.800 GeneticVariation GWASCAT Genetic analysis of quantitative traits in the Japanese population links cell types to complex human diseases. 29403010

2018
dbSNP: rs651821
rs651821
APOA5
CUI: C0392885
Disease: High density lipoprotein measurement
High density lipoprotein measurement 		C 0.800 GeneticVariation GWASCAT A large electronic-health-record-based genome-wide study of serum lipids. 29507422

2018
dbSNP: rs651821
rs651821
APOA5
CUI: C1445957
Disease: Serum total cholesterol measurement
Serum total cholesterol measurement 		C 0.800 GeneticVariation GWASCAT A large electronic-health-record-based genome-wide study of serum lipids. 29507422

2018
dbSNP: rs651821
rs651821
APOA5
CUI: C0202236
Disease: Triglycerides measurement
Triglycerides measurement 		C 0.800 GeneticVariation GWASCAT A large electronic-health-record-based genome-wide study of serum lipids. 29507422

2018
dbSNP: rs651821
rs651821
APOA5
CUI: C0202236
Disease: Triglycerides measurement
Triglycerides measurement 		C 0.800 GeneticVariation GWASCAT Susceptibility loci for metabolic syndrome and metabolic components identified in Han Chinese: a multi-stage genome-wide association study. 28371326

2017
dbSNP: rs651821
rs651821
APOA5
CUI: C0392885
Disease: High density lipoprotein measurement
High density lipoprotein measurement 		T 0.800 GeneticVariation GWASCAT Association analyses of East Asian individuals and trans-ancestry analyses with European individuals reveal new loci associated with cholesterol and triglyceride levels. 28334899

2017
dbSNP: rs651821
rs651821
APOA5
CUI: C0392885
Disease: High density lipoprotein measurement
High density lipoprotein measurement 		C 0.800 GeneticVariation GWASCAT Susceptibility loci for metabolic syndrome and metabolic components identified in Han Chinese: a multi-stage genome-wide association study. 28371326

2017
dbSNP: rs651821
rs651821
APOA5
CUI: C0202236
Disease: Triglycerides measurement
Triglycerides measurement 		G 0.800 GeneticVariation GWASCAT Genome-wide association study of serum lipids confirms previously reported associations as well as new associations of common SNPs within PCSK7 gene with triglyceride. 26763881

2016
dbSNP: rs651821
rs651821
APOA5
CUI: C0202236
Disease: Triglycerides measurement
Triglycerides measurement 		C 0.800 GeneticVariation GWASCAT A genome wide association study identifies common variants associated with lipid levels in the Chinese population. 24386095

2013
dbSNP: rs651821
rs651821
APOA5
CUI: C1445957
Disease: Serum total cholesterol measurement
Serum total cholesterol measurement 		C 0.800 GeneticVariation GWASDB A genome wide association study identifies common variants associated with lipid levels in the Chinese population. 24386095

2013
dbSNP: rs651821
rs651821
APOA5
CUI: C0392885
Disease: High density lipoprotein measurement
High density lipoprotein measurement 		0.800 GeneticVariation GWASDB Large-scale gene-centric meta-analysis across 32 studies identifies multiple lipid loci. 23063622

2012
dbSNP: rs651821
rs651821
APOA5
CUI: C0523744
Disease: Lipids measurement
Lipids measurement 		0.800 GeneticVariation GWASDB Genome-wide association study identifies multiple loci influencing human serum metabolite levels. 22286219

2012
dbSNP: rs651821
rs651821
APOA5
CUI: C0202236
Disease: Triglycerides measurement
Triglycerides measurement 		0.800 GeneticVariation GWASCAT A genome-wide association and gene-environment interaction study for serum triglycerides levels in a healthy Chinese male population. 22171074

2012
dbSNP: rs651821
rs651821
APOA5
CUI: C1445957
Disease: Serum total cholesterol measurement
Serum total cholesterol measurement 		0.800 GeneticVariation GWASDB Large-scale gene-centric meta-analysis across 32 studies identifies multiple lipid loci. 23063622

2012
dbSNP: rs651821
rs651821
APOA5
CUI: C0523744
Disease: Lipids measurement
Lipids measurement 		0.800 GeneticVariation GWASCAT Genome-wide association study identifies multiple loci influencing human serum metabolite levels. 22286219

2012
dbSNP: rs651821
rs651821
APOA5
CUI: C0202236
Disease: Triglycerides measurement
Triglycerides measurement 		0.800 GeneticVariation GWASDB A genome-wide association and gene-environment interaction study for serum triglycerides levels in a healthy Chinese male population. 22171074

2012
dbSNP: rs651821
rs651821
APOA5
CUI: C0202236
Disease: Triglycerides measurement
Triglycerides measurement 		0.800 GeneticVariation GWASDB Large-scale gene-centric meta-analysis across 32 studies identifies multiple lipid loci. 23063622

2012
dbSNP: rs651821
rs651821
APOA5
CUI: C0524620
Disease: Metabolic Syndrome X
Metabolic Syndrome X 		C 0.720 GeneticVariation GWASCAT Notably, by an integrated analysis of the genotypes and the serum levels of APOA5, BUD13 and triglyceride, we observed that BUD13 was another potential mediator, besides APOA5, of the association between rs651821 and serum triglyceride. rs671 (ALDH2), an east Asian-specific common variant, was found to be associated with MetS (P<sub>combined</sub> = 9.7 × 10<sup>-22</sup> ) in Han Chinese. 28371326

2017
dbSNP: rs651821
rs651821
APOA5
CUI: C0524620
Disease: Metabolic Syndrome X
Metabolic Syndrome X 		0.720 GeneticVariation BEFREE Even after adjustment for MetS status, reduced abundances of Actinobacteria and <i>Bifidobacterium</i> were significantly linked to the minor allele at the <i>APOA5</i> SNP rs651821. 27053630

2017
dbSNP: rs651821
rs651821
APOA5
CUI: C0524620
Disease: Metabolic Syndrome X
Metabolic Syndrome X 		0.720 GeneticVariation BEFREE Notably, by an integrated analysis of the genotypes and the serum levels of APOA5, BUD13 and triglyceride, we observed that BUD13 was another potential mediator, besides APOA5, of the association between rs651821 and serum triglyceride. rs671 (ALDH2), an east Asian-specific common variant, was found to be associated with MetS (P<sub>combined</sub> = 9.7 × 10<sup>-22</sup> ) in Han Chinese. 28371326

2017
dbSNP: rs651821
rs651821
APOA5
CUI: C1956346
Disease: Coronary Artery Disease
Coronary Artery Disease 		T 0.710 GeneticVariation GWASCAT Identification of 64 Novel Genetic Loci Provides an Expanded View on the Genetic Architecture of Coronary Artery Disease. 29212778

2018