rs1217691063
|
|
Malignant tumor of colon
|
|
0.100 |
GeneticVariation
|
BEFREE |
In summary, this meta-analysis suggests that MTHFR C677T polymorphism is associated with increased breast cancer, gastric cancer, and hepatocellular cancer risk in Asians, is associated with increased gastric cancer, multiple myeloma, and NHL risk in Caucasians, is associated with decreased AALL risk in Caucasians, is associated with decreased CALL risk in Asians, is associated with increased breast cancer risk in Asians, is associated with decreased colon cancer risk, and is associated with decreased colorectal cancer risk in male population.
|
26081619 |
2015 |
rs1217691063
|
|
Malignant tumor of colon
|
|
0.100 |
GeneticVariation
|
BEFREE |
Association between rectal or colon cancer risk and serine hydroxymethyltransferase 1 (SHMT1) C1420T or methylenetetrahydrofolate reductase (MTHFR) C677T polymorphisms was assessed.
|
20920350 |
2010 |
rs1217691063
|
|
Malignant tumor of colon
|
|
0.100 |
GeneticVariation
|
BEFREE |
An interaction was observed between the MTHFR C677T polymorphism and freshwater fish consumption on colon cancer risk (P value for interaction = 0.031).
|
20551579 |
2010 |
rs1217691063
|
|
Malignant tumor of colon
|
|
0.100 |
GeneticVariation
|
BEFREE |
The C677T polymorphism in the methylenetetrahydrofolate reductase (MTHFR) gene is associated with a decreased risk of colon cancer although it may increase the risk of breast cancer.
|
19123462 |
2009 |
rs1217691063
|
|
Malignant tumor of colon
|
|
0.100 |
GeneticVariation
|
BEFREE |
(1) When men and women were assessed together, the frequencies of the MTHFR C677T and A1298 genotypes or their alleles were not significantly different between controls and co</span>lon cancer or rectal cancer cases.
|
18712959 |
2009 |
rs1217691063
|
|
Malignant tumor of colon
|
|
0.100 |
GeneticVariation
|
BEFREE |
Recently, methylenetetrahydrofolate reductase (MTHFR C677T and A1298C) mutations were discovered to be associated with childhood acute lymphoblastic leukemia (ALL), as well as colon cancer, lymphoma, esophageal and stomach cancer.
|
16886608 |
2006 |
rs1217691063
|
|
Malignant tumor of colon
|
|
0.100 |
GeneticVariation
|
BEFREE |
Adequate intake of folate was a protective factor from colon cancer (OR=0.32, 95% CI: 0.12-0.88) and MTHFR C677T</span> polymorphism showed a statistically significant effect (OR=0.25, 95% CI: 0.06-0.93), reducing the risk of colon cancer in groups that have an intake of folate exceeding 115.64ng per 1000kcal per day.
|
15829374 |
2005 |
rs1217691063
|
|
Malignant tumor of colon
|
|
0.100 |
GeneticVariation
|
BEFREE |
The 5,10-methylenetetrahydrofolate reductase gene (MTHFR) 677C-->T polymorphism modifies the risk of coronary artery disease and colon cancer and is related to plasma concentrations of total homocysteine (tHcy).
|
15447919 |
2004 |
rs1217691063
|
|
Malignant tumor of colon
|
|
0.100 |
GeneticVariation
|
BEFREE |
Using data from an incident case-control study (1608 cases and 1972 controls) we investigated two polymorphisms in the MTHFR gene, C677T and A1298C, and their associations with risk of colon cancer.
|
14973104 |
2004 |
rs1217691063
|
|
Malignant tumor of colon
|
|
0.100 |
GeneticVariation
|
BEFREE |
Methylenetetrahydrofolate reductase 677 C-->T polymorphism and risk of proximal colon cancer in north Italy.
|
12576444 |
2003 |
rs1217691063
|
|
Malignant tumor of colon
|
|
0.100 |
GeneticVariation
|
BEFREE |
The MTHFR polymTHFR polymorphisms, especially the 677C-->T mutation, may contribute to vascular and birth defect risks, while reducing the risk of certain malignancies, such as colon cancer.
|
14633777 |
2003 |
rs397507444
|
|
Malignant tumor of colon
|
|
0.090 |
GeneticVariation
|
BEFREE |
The MTHFR A1298C polymorphism was associated with risk of colon cancer.
|
24533714 |
2014 |
rs397507444
|
|
Malignant tumor of colon
|
|
0.090 |
GeneticVariation
|
BEFREE |
However, risk was significantly increased for MTHFR A1298C polymorphisms and colon cancer risk in hospital-based studies (C vs A: OR=1.52, 95%CI=1.26-1.83, p=0.000; CC+AC vs AA: OR=1.93, 95%CI=1.47-2.49, p=0.000) but reduced in population-based studies (CC vs AA: OR=0.83, 95%CI=0.70-0.99, p=0.042).
|
25339013 |
2014 |
rs397507444
|
|
Malignant tumor of colon
|
|
0.090 |
GeneticVariation
|
BEFREE |
A haplotype of A66G and A1298C polymorphisms, A/A, proved to be protective (OR=0.775; 95% CI=0.603-0.996; p=0.04), whereas haplotype A/G was a risk factor for colon cancer (OR=1.270; 95% CI=1.007-1.602; p=0.04).
|
21438757 |
2011 |
rs397507444
|
|
Malignant tumor of colon
|
|
0.090 |
GeneticVariation
|
BEFREE |
Interactions were observed between the MTHFR A1298C polymorphism and bowel habits, family history of cancer, alcohol consumption, and beef consumption on colon cancer risk (P-value for interaction = 0.0005, 0.007, 0.067, 0.003, respectively).
|
20551579 |
2010 |
rs397507444
|
|
Malignant tumor of colon
|
|
0.090 |
GeneticVariation
|
BEFREE |
Individuals who had C677T T/T and A1298C A/A genotypes were at an increased risk of developing colon cancer (adjusted OR=2.64, 95%CI: 1.20-5.81) compared with those with C677T C allele and A1298C A/A genotypes among males.
|
18712959 |
2009 |
rs397507444
|
|
Malignant tumor of colon
|
|
0.090 |
GeneticVariation
|
BEFREE |
Recently, methylenetetrahydrofolate reductase (MTHFR C677T and A1298C) mutations were discovered to be associated with childhood acute lymphoblastic leukemia (ALL), as well as colon cancer, lymphoma, esophageal and stomach cancer.
|
16886608 |
2006 |
rs397507444
|
|
Malignant tumor of colon
|
|
0.090 |
GeneticVariation
|
BEFREE |
The aim of this study was to investigate the association of environmental factors (dietary folate, methionine and drinking status) and polymorphisms in the methylenetetrahydrofolate reductase (MTHFR C677T and A1298C) gene, as well as the combination of these factors, with the risk of colon cancer and rectal cancer.
|
15829374 |
2005 |
rs397507444
|
|
Malignant tumor of colon
|
|
0.090 |
GeneticVariation
|
BEFREE |
While the A1298C polymorphism showed no measurable association with the overall risk of colorectal cancer, the 1298CC genotype was associated with a statistically significant increase in the risk when alcohol consumption was high, and was also associated with an approximately 2-fold increase in the risk of each of proximal and distal colon cancer.
|
15546509 |
2004 |
rs397507444
|
|
Malignant tumor of colon
|
|
0.090 |
GeneticVariation
|
BEFREE |
In summary, this study supports recent findings that the MTHFR A1298C polymorphism may be a predictor of colon cancer risk and have functional relevance.
|
14973104 |
2004 |
rs1801133
|
|
Malignant tumor of colon
|
|
0.010 |
GeneticVariation
|
BEFREE |
However, <i>MTHFR</i> rs1801133 G>A polymorphism conferred a decreased risk to colon cancer.
|
28969008 |
2017 |
rs3753584
|
|
Malignant tumor of colon
|
|
0.010 |
GeneticVariation
|
BEFREE |
In a stratified analysis by CRC region, we found <i>MTHFR</i> rs3753584 T>C and rs9651118 T>C polymorphisms were associated with the increased risk of colon cancer.
|
28969008 |
2017 |
rs9651118
|
|
Malignant tumor of colon
|
|
0.010 |
GeneticVariation
|
BEFREE |
In a stratified analysis by CRC region, we found <i>MTHFR</i> rs3753584 T>C and rs9651118 T>C polymorphisms were associated with the increased risk of colon cancer.
|
28969008 |
2017 |