|
rs662
|
|
Coronary heart disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
This meta-analysis suggests that the association between the PON1 rs662 polymorphism and CHD may partly be mediated by abnormal Ox-LDL and lipid levels caused by the R allele.
|
30545386 |
2018 |
|
rs662
|
|
Coronary heart disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
This meta-analysis suggests that the PON1 Q192R polymorphism has a weak association with CHD risk in Chinese.
|
29952962 |
2018 |
|
rs662
|
|
Coronary heart disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
The activity of PON1 is decreased in patients with coronary artery disease, myocardial infarction or chronic kidney disease. rs662 and rs854560 are single nucleotide polymorphisms (SNPs) associated with PON1 activity and 10-year cardiovascular mortality of patients with stable coronary artery disease.
|
25155309 |
2016 |
|
rs662
|
|
Coronary heart disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
Two PON1 SNPs, rs662 and rs3735590, were found to significantly interact with cigarette smoking to modulate the risk of CHD in the Singaporean Chinese population.
|
25746376 |
2015 |
|
rs662
|
|
Coronary heart disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
Association between PON1 rs662 polymorphism and coronary artery disease.
|
24918121 |
2014 |
|
rs662
|
|
Coronary heart disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
Association of paraoxonase1 gene Q192R polymorphism and apolipoprotein B in Asian Indian women with coronary artery disease risk.
|
23171143 |
2013 |
|
rs662
|
|
Coronary heart disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
The Q192R polymorphism of the paraoxonase 1 gene is a risk factor for coronary artery disease in Saudi subjects.
|
23625196 |
2013 |
|
rs662
|
|
Coronary heart disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
Interaction of folate intake and the paraoxonase Q192R polymorphism with risk of incident coronary heart disease and ischemic stroke: the atherosclerosis risk in communities study.
|
21982484 |
2011 |
|
rs662
|
|
Coronary heart disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
We tested the clinical relevance of the PON1 Q192R genotype in a population of individuals with coronary artery disease who underwent stent implantation and received clopidogrel therapy.
|
21170047 |
2011 |
|
rs662
|
|
Coronary heart disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
A preliminary study of human paraoxonase and PON 1 L/M55-PON 1 Q/R 192 polymorphisms in Turkish patients with coronary artery disease.
|
19226538 |
2009 |
|
rs662
|
|
Coronary heart disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
We conclude that the Q192R polymorphism of PON1 significantly modulates the HDL-C response to simvastatin in Chinese patients with CHD.
|
18430057 |
2008 |
|
rs662
|
|
Coronary heart disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
Paraoxonase-1 (PON1) activity, but not PON1(Q192R) phenotype, is a predictor of coronary artery disease in a middle-aged Serbian population.
|
17032132 |
2006 |
|
rs662
|
|
Coronary heart disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
There is no robust evidence that the PON1 Q192R polymorphism is associated with CHD risk in Caucasian women or men.
|
15214960 |
2004 |
|
rs662
|
|
Coronary heart disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
Using self-reported data on ischemic heart disease to evaluate the impact of the PON 192Q/R polymorphism on susceptibility to CHD, we found only a nonsignificant trend of 192RR homozygosity in women being a risk factor.
|
15241482 |
2004 |
|
rs662
|
|
Coronary heart disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
The weak overall association between the Q192R polymorphism and CHD is of uncertain relevance, particularly since there was no significant association among the larger studies which should be less prone to selective publication.
|
15001326 |
2004 |
|
rs662
|
|
Coronary heart disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
Different pattern of association of paraoxonase Gln192-->Arg polymorphism with sporadic late-onset Alzheimer's disease and coronary artery disease.
|
12618290 |
2003 |
|
rs662
|
|
Coronary heart disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
Two cSNPs in PON1 (L55M and Q192R) and one in PON2 (S311C) have been implicated as independent risk factors for coronary heart disease (CHD) in some, but not all, studies.
|
14636952 |
2003 |
|
rs662
|
|
Coronary heart disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
Homozygosity for the 55L-allele was significantly associated with CHD (p = 0.02), while the Gln192Arg polymorphism had no effect (p = 0.16).
|
12417809 |
2002 |
|
rs662
|
|
Coronary heart disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
Its enzymatic serum activity varies 10-40-fold between individuals, and its biallelic gene polymorphism at codon 192 (glutamine-->arginine, Gln/Arg) has been associated with coronary artery disease in diabetic patients.
|
11409295 |
2001 |
|
rs662
|
|
Coronary heart disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
Coronary artery disease risk in Chinese type 2 diabetics: is there a role for paraxonase 1 gene (Q192R) polymorphism?
|
11375798 |
2001 |
|
rs662
|
|
Coronary heart disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
Studies have been conducted to evaluate the possible "protective" role of PON, and especially the influence of the Arg-->Gln 192 polymorphism, in coronary artery disease.
|
9746266 |
1998 |
|
rs662
|
|
Coronary heart disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
It has been hypothesized an A/B (Gln 192-->Arg) polymorphism of PON may be involved in the pathogenesis of CHD, especially among subjects with non-insulin-dependent diabetes mellitus (NIDDM).
|
8960946 |
1996 |