Source: ALL

Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs744166
rs744166
STAT3
CUI: C0010346
Disease: Crohn Disease
Crohn Disease 		0.870 GeneticVariation BEFREE The presence of (C) in rs10758669, (T) and (TT) in rs957970, and (TT) in rs744166 were found to increase the susceptibility to Crohn's disease (p=0.049, p=0.016, p=0.010, p=0.035, respectively), while rs2293152 (GC), rs744166 (CT), and rs957970 (CT) provide protection against Crohn's disease (p=0.007, p=0.043, p=0.043, respectively). 27852544

2016
dbSNP: rs744166
rs744166
STAT3
CUI: C0010346
Disease: Crohn Disease
Crohn Disease 		0.870 GeneticVariation BEFREE Our results support an important association of rs744166 and rs4796793 with decreased CD risk, and additional interaction between rs744166 and smoking. 27022745

2016
dbSNP: rs744166
rs744166
STAT3
CUI: C0010346
Disease: Crohn Disease
Crohn Disease 		0.870 GeneticVariation BEFREE This meta-analysis indicates that carriers of the STAT3 rs744166 'A' allele have a significantly greater risk of CD and UC, especially among Caucasians. 25286337

2014
dbSNP: rs744166
rs744166
STAT3
CUI: C0010346
Disease: Crohn Disease
Crohn Disease 		0.870 GeneticVariation BEFREE STAT3 rs744166 and rs4796793 polymorphisms may be associated with CD occurrence and used as a predictive factor of CD in Chinese Han populations. 24885273

2014
dbSNP: rs744166
rs744166
STAT3
CUI: C0010346
Disease: Crohn Disease
Crohn Disease 		0.870 GeneticVariation BEFREE Here, we studied the susceptibility nature of three components of IL23 signalling and Th17 cell differentiation: JAK2 rs10758669, STAT3 rs744166 and CCR6 rs2301436 initially associated with CD in Hungarian CD and UC patients. 22269120

2012
dbSNP: rs744166
rs744166
STAT3
CUI: C0010346
Disease: Crohn Disease
Crohn Disease 		0.870 GeneticVariation BEFREE JAK2 rs10758669 and STAT3 rs744166 increase susceptibility for CD. 22065112

2012
dbSNP: rs744166
rs744166
STAT3
CUI: C0010346
Disease: Crohn Disease
Crohn Disease 		0.870 GeneticVariation BEFREE Allelic association analysis (two-tailed) showed that three of the five targeted SNPs were significantly associated with overall susceptibility for CD (ZNF365, r10995271, P = 0.001; PTPN2, rs1893217, P = 0.005; STAT3, rs744166, P = 0.01). 20222910

2010
dbSNP: rs744166
rs744166
STAT3
CUI: C0010346
Disease: Crohn Disease
Crohn Disease 		A 0.870 GeneticVariation GWASCAT Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease. 18587394

2008
dbSNP: rs744166
rs744166
STAT3
CUI: C0010346
Disease: Crohn Disease
Crohn Disease 		A 0.870 GeneticVariation GWASDB Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease. 18587394

2008