|
rs3212986
|
|
Glioma
|
|
0.070 |
GeneticVariation
|
BEFREE |
This meta-analysis suggests that glioma susceptibility is associated with rs1799782 and rs25487 of X-ray repair complementing defective repair in Chinese hamster cells 1 (XRCC1), rs1805377 of XRCC4, rs1800067 of excision repair cross-complementing rodent repair deficiency complementation group 4 (ERCC4) and rs3212986 of ERCC1 in Asian population, and rs12917 of O-6-methylguanine-DNA methyltransferase (MGMT) and rs1136410 of poly(ADP-ribose) polymerase 1 (PARP1) in Caucasian population.
|
27055523 |
2017 |
|
rs3212986
|
|
Glioma
|
|
0.070 |
GeneticVariation
|
BEFREE |
Our meta-analysis indicated that the ERCC1 rs3212986 polymorphism and 2 polymorphisms in ERCC2 gene (rs13181 and rs1799793) contributed to the susceptibility of glioma.
|
28514298 |
2017 |
|
rs3212986
|
|
Glioma
|
|
0.070 |
GeneticVariation
|
BEFREE |
Genetic variants found in DNA repair genes (ERCC1, rs3212986; ERCC2, rs13181; ERCC4, rs1800067; ERCC5, rs17655; XRCC1, rs1799782, rs25487, rs25489; XRCC3, rs861539) have been reported to have an ambivalent association with the development of glioma.
|
26843108 |
2017 |
|
rs3212986
|
|
Glioma
|
|
0.070 |
GeneticVariation
|
BEFREE |
ERCC1 rs3212986 is a common single nucleotide polymorphism and may contribute toward individual susceptibility for glioma.
|
26264164 |
2016 |
|
rs3212986
|
|
Glioma
|
|
0.070 |
GeneticVariation
|
BEFREE |
Subgroup analysis showed that the ERCC1 rs3212986 AA genotype was significantly associated with an increased risk of glioma in the Chinese population (odds ratio = 1.37, 95% confidence interval = 1.07-1.55), but no association in Caucasian Chinese.
|
25867436 |
2015 |
|
rs3212986
|
|
Glioma
|
|
0.070 |
GeneticVariation
|
BEFREE |
For ERCC1 C8092A (dbSNP: rs3212986, C>A), the combined results show that carriers of the AA genotype may be associated with a higher risk of adult glioma than carriers of the CA and CC genotypes.
|
24254311 |
2014 |
|
rs3212986
|
|
Glioma
|
|
0.070 |
GeneticVariation
|
BEFREE |
We found that SNPs rs3212986 (odds ratio [OR] = 1.35 (1.08-1.68), P = .008), rs13181 (OR = 1.18 (1.06-1.31), P = .002), and rs25487 (OR = 1.12 (1.03-1.22), P = .007) in DNA repair genes ERCC1, ERCC2 (XPD), and XRCC1 may increase the risk of glioma, while polymorphisms rs1136410 (OR = 0.78 (0.68-0.89), P = .0004) and rs12917 (OR = 0.84 (0.73-0.96), P = .01) in PARP1(ADPRT) and MGMT are associated with decreased susceptibility to glioma.
|
24500421 |
2014 |