|
rs2296651
|
|
Hepatitis B
|
|
0.100 |
GeneticVariation
|
BEFREE |
The study highlighted the role of the SLC10A1 S267F variant in the loss of the ability to support HBV infection and taurocholate transport activity.
|
31177598 |
2019 |
|
rs2296651
|
|
Hepatitis B
|
|
0.100 |
GeneticVariation
|
BEFREE |
The S267F variant was found more frequently among HCs (16%) compared to HBV-infected (6%) and HBV-HDV co-infected patients (3%) (HBV patients vs HC: OR=0.32, P=0.00002 and HDV patients vs. HC: OR=0.17, P=0.018).
|
30685591 |
2019 |
|
rs2296651
|
|
Hepatitis B
|
|
0.100 |
GeneticVariation
|
BEFREE |
Our results showed that rs2296651 polymorphism was associated with a decreased risk of susceptibility to HBV infection and the development of HCC.
|
31117968 |
2019 |
|
rs2296651
|
|
Hepatitis B
|
|
0.100 |
GeneticVariation
|
BEFREE |
Viral and host predictors of relapse were evaluated, including hepatitis B virus (HBV) surface antigen (HBsAg) level, anti-HBV core antibody level, and presence of single-nucleotide polymorphisms in the genes encoding the receptors NTCP (rs2296651) and CTLA4 (rs231775) and in the 3' untranslated regions of the genes encoding HLA-DPA1 (rs3077) and HLA-DPB1 (rs9277535); posttherapy predictors of relapse were also investigated.
|
29300980 |
2018 |
|
rs2296651
|
|
Hepatitis B
|
|
0.100 |
GeneticVariation
|
BEFREE |
The S267F variant for the HBV cell-entry receptor NTCP was associated with increased resistance to HBV infection and decreased risk for cirrhosis and liver cancer among those with chronic HBV infection.
|
29905807 |
2018 |
|
rs2296651
|
|
Hepatitis B
|
|
0.100 |
GeneticVariation
|
BEFREE |
The S267F variant may be a protective factor to resist chronic hepatitis B progression which showed a higher bile acid level in Chinese Han chronic HBV infection patients.
|
29205714 |
2018 |
|
rs2296651
|
|
Hepatitis B
|
|
0.100 |
GeneticVariation
|
BEFREE |
The p.Ser267Phe variant of sodium taurocholate cotransporting polypeptide (NTCP) supports HBV infection with a low efficiency.
|
30032030 |
2018 |
|
rs2296651
|
|
Hepatitis B
|
|
0.100 |
GeneticVariation
|
BEFREE |
The S267F variant on the NTCP gene is independently associated with sustained normalization of ALT following treatment with PEG-IFN in patients with HBV infection who are HBeAg-positive.
|
28635613 |
2018 |
|
rs2296651
|
|
Hepatitis B
|
|
0.100 |
GeneticVariation
|
BEFREE |
Hepatitis B virus infection in Taiwan: The role of NTCP rs2296651 variant in relation to sex.
|
29660219 |
2018 |
|
rs2296651
|
|
Hepatitis B
|
|
0.100 |
GeneticVariation
|
BEFREE |
Analysis of hepatitis B virus preS1 variability and prevalence of the rs2296651 polymorphism in a Spanish population.
|
29456407 |
2018 |
|
rs2296651
|
|
Hepatitis B
|
|
0.100 |
GeneticVariation
|
BEFREE |
In conclusion, the S267F variant of NTCP is clinically associated with a lower risk of chronic HBV infection and cirrhosis development, which implicates suppressing HBV entry could reduce the disease burden.
|
29247233 |
2017 |
|
rs2296651
|
|
Hepatitis B
|
|
0.100 |
GeneticVariation
|
BEFREE |
The role of SLC10A1 polymorphisms, particularly the Ser267Phe variant (rs2296651) in exon 4, has been frequently investigated in regard to risk of persistent HBV infection.
|
28429786 |
2017 |
|
rs2296651
|
|
Hepatitis B
|
|
0.100 |
GeneticVariation
|
BEFREE |
The S267F variant is absent among Moroccans regardless of chronic HBV infection status.
|
28125961 |
2017 |
|
rs2296651
|
|
Hepatitis B
|
|
0.100 |
GeneticVariation
|
BEFREE |
Meta-analysis also showed that NTCP rs2296651-GA was inversely associated with HBV infection [OR(95%CI)=0.532(0.287-0.986), <i>p</i>=0.028, codominant] or HBV-related HCC [OR(95%CI)=0.701(0.564-0.872), <i>p</i>=0.001, recessive].
|
29285260 |
2017 |
|
rs2296651
|
|
Hepatitis B
|
|
0.100 |
GeneticVariation
|
BEFREE |
The p.Ser267Phe variant was associated with healthy status (P = 5.7 × 10(-23) , odds ratio = 0.36) irrespective of hepatitis B virus surface antibody status (P = 6.2 × 10(-21) and 1.5 × 10(-10) , respectively, when the cases were compared with hepatitis B virus surface antibody-positive and -negative controls).
|
25418280 |
2015 |
|
rs2296651
|
|
Hepatitis B
|
|
0.100 |
GeneticVariation
|
BEFREE |
These findings suggest that the rs2296651 polymorphism may predispose the susceptibility to and chronicity of HBV infection.
|
24735529 |
2014 |
|
rs201339654
|
|
Hepatitis B
|
|
0.010 |
GeneticVariation
|
BEFREE |
An exchange from arginine to glycine (as present in humans and great apes) at this position (R158G) alone was sufficient to achieve full transport-competing HBV myr-preS1-peptide binding and susceptibility for HBV/HDV infection.
|
29912972 |
2018 |
|
rs4646285
|
|
Hepatitis B
|
|
0.010 |
GeneticVariation
|
BEFREE |
The rs4646285 variants could influence the expression of NTCP at the level of transcription, and ultimately may be associated with HBV infection immune recovery.
|
29205714 |
2018 |
|
rs4646287
|
|
Hepatitis B
|
|
0.010 |
GeneticVariation
|
BEFREE |
We found a genetic variant (rs4646287) located in intron 1 of NTCP that may be associated with increased risk of HBV infection in Han Chinese.
|
26968990 |
2016 |
|
rs7154439
|
|
Hepatitis B
|
|
0.010 |
GeneticVariation
|
BEFREE |
The rs7154439 AA genotype was associated with HBV clearance, while the rs4646287 AA genotype was associated with HCC occurrence.
|
25010264 |
2014 |
|
rs943277
|
|
Hepatitis B
|
|
0.010 |
GeneticVariation
|
BEFREE |
Furthermore, the frequency of rs943277-GA was positively correlated with HBV infection [adjusted OR(95%CI)=2.42(1.05-5.54), <i>p</i>=0.032, codominant].
|
29285260 |
2017 |