|
rs2300747
|
|
Multiple Sclerosis
|
|
0.820 |
GeneticVariation
|
BEFREE |
The goal of the current study was to investigate the association of single nucleotide polymorphisms (SNP) with the immunologically related genes responsible for the disease, composed of CD58 (rs2300747 A>G), CD226 (rs763361 C>T), and HLA-G (rs1611715 A>C), with MS susceptibility.
|
30128676 |
2018 |
|
rs2300747
|
|
Multiple Sclerosis
|
|
0.820 |
GeneticVariation
|
GWASCAT |
Novel multiple sclerosis susceptibility loci implicated in epigenetic regulation.
|
27386562 |
2016 |
|
rs2300747
|
|
Multiple Sclerosis
|
|
0.820 |
GeneticVariation
|
GWASDB |
Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis.
|
21833088 |
2011 |
|
rs2300747
|
|
Multiple Sclerosis
|
A |
0.820 |
GeneticVariation
|
GWASCAT |
Genome-wide meta-analysis identifies novel multiple sclerosis susceptibility loci.
|
22190364 |
2011 |
|
rs2300747
|
|
Multiple Sclerosis
|
A |
0.820 |
GeneticVariation
|
GWASDB |
Genome-wide meta-analysis identifies novel multiple sclerosis susceptibility loci.
|
22190364 |
2011 |
|
rs2300747
|
|
Multiple Sclerosis
|
A |
0.820 |
GeneticVariation
|
GWASCAT |
Meta-analysis of genome scans and replication identify CD6, IRF8 and TNFRSF1A as new multiple sclerosis susceptibility loci.
|
19525953 |
2009 |
|
rs2300747
|
|
Multiple Sclerosis
|
|
0.820 |
GeneticVariation
|
BEFREE |
This protective rs2300747(G) allele is associated with a dose-dependent increase in CD58 mRNA expression in lymphoblastic cell lines (P = 1.1 x 10(-10)) and in peripheral blood mononuclear cells from MS </span>subjects (P = 0.0037).
|
19237575 |
2009 |
|
rs2300747
|
|
Multiple Sclerosis
|
A |
0.820 |
GeneticVariation
|
GWASDB |
Meta-analysis of genome scans and replication identify CD6, IRF8 and TNFRSF1A as new multiple sclerosis susceptibility loci.
|
19525953 |
2009 |
|
rs1335532
|
|
Multiple Sclerosis
|
|
0.810 |
GeneticVariation
|
BEFREE |
In summary, our results suggest that ASCL2 mediates the protective function of rs1335532 minor (C) allele in MS.
|
30006149 |
2018 |
|
rs1335532
|
|
Multiple Sclerosis
|
A |
0.810 |
GeneticVariation
|
GWASDB |
No evidence for shared genetic basis of common variants in multiple sclerosis and amyotrophic lateral sclerosis.
|
24234648 |
2014 |
|
rs1335532
|
|
Multiple Sclerosis
|
A |
0.810 |
GeneticVariation
|
GWASDB |
Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis.
|
21833088 |
2011 |
|
rs1335532
|
|
Multiple Sclerosis
|
A |
0.810 |
GeneticVariation
|
GWASCAT |
Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis.
|
21833088 |
2011 |
|
rs1335532
|
|
Multiple Sclerosis
|
|
0.810 |
GeneticVariation
|
GWASDB |
Genome-wide meta-analysis identifies novel multiple sclerosis susceptibility loci.
|
22190364 |
2011 |
|
rs1335532
|
|
Multiple Sclerosis
|
A |
0.810 |
GeneticVariation
|
GWASDB |
Genome-wide association study identifies new multiple sclerosis susceptibility loci on chromosomes 12 and 20.
|
19525955 |
2009 |
|
rs1335532
|
|
Multiple Sclerosis
|
A |
0.810 |
GeneticVariation
|
GWASCAT |
Genome-wide association study identifies new multiple sclerosis susceptibility loci on chromosomes 12 and 20.
|
19525955 |
2009 |
|
rs6677309
|
|
Multiple Sclerosis
|
A |
0.700 |
GeneticVariation
|
GWASCAT |
Analysis of immune-related loci identifies 48 new susceptibility variants for multiple sclerosis.
|
24076602 |
2013 |
|
rs12044852
|
|
Multiple Sclerosis
|
|
0.010 |
GeneticVariation
|
BEFREE |
We observed a trend for association of rs3135388 (HLA-DRB1*1501, p < 0.01), rs7090530 (IL2RA, p < 0.026) and rs1841770 (ZIC1, p < 0.017) with a younger age at MS onset and of rs12044852 (CD58, p < 0.035) with shorter time to reach EDSS6.
|
22411505 |
2012 |
|
rs1414273
|
|
Multiple Sclerosis
|
|
0.010 |
GeneticVariation
|
BEFREE |
Sequencing data of the 1000 Genomes project revealed a SNP, rs1414273, at the base of the microRNA stem-loop to be in strong linkage disequilibrium with the MS-associated haplotype.
|
25795118 |
2015 |