rs3212227
|
|
Psoriasis
|
|
0.100 |
GeneticVariation
|
BEFREE |
Case-control analysis revealed an association of IL12B rs3212227 and IL23R rs11209026 minor allele carrier status with reduced odds for psoriasis (OR = 0.66, 95%CI: 0.50-0.87, and OR = 0.41, 95%CI: 0.26-0.67, respectively), while HLA-C*06 allele carriers were more frequent in patients group (OR = 4.56, 95%CI: 3.41-6.10).
|
29454820 |
2018 |
rs3212227
|
|
Psoriasis
|
|
0.100 |
GeneticVariation
|
BEFREE |
We found both SNPs were significantly associated with psoriasis</span> (rs7709212: odds ratio (OR)=1.37, P-value=1.09 × 10<sup>-5</sup>; rs321</span>2227: OR=1.38, P-value=8.88 × 10<sup>-6</sup>).
|
27829679 |
2017 |
rs3212227
|
|
Psoriasis
|
|
0.100 |
GeneticVariation
|
BEFREE |
Our results suggest that IL-12B (rs3212227) and IL-23R (rs2201841) polymorphisms confer increased risk of psoriasis in our ethnic South Indian Tamils.
|
26472011 |
2016 |
rs3212227
|
|
Psoriasis
|
|
0.100 |
GeneticVariation
|
BEFREE |
This study aims to assess whether the association between the non-susceptibility allelic variants of IL12B single-nucleotide polymorphism (SNPs) rs3212227 and rs6887695, IL23R SNPs rs11209026 and rs7530511, IL6 SNP rs1800795 and HLA-Cw6 could be correlated with decreased risk for psoriasis.
|
24140476 |
2014 |
rs3212227
|
|
Psoriasis
|
|
0.100 |
GeneticVariation
|
BEFREE |
This meta-analysis showed that the IL-23 R (rs11209026 and rs7530511) polymorphisms are associated with psoriasis risk in Europeans and that the IL-12B (rs6887695 and rs3212227) polymorphisms are associated with susceptibility to psoriasis in Europeans.
|
23844553 |
2013 |
rs3212227
|
|
Psoriasis
|
|
0.100 |
GeneticVariation
|
BEFREE |
For rs3212227, the odds ratios the minor allele for psoriasis and PsA were 0.688 (95 % CI 0.650-0.729) and 0.707 (95 % CI 0.628-0.797), respectively.
|
23297015 |
2013 |
rs3212227
|
|
Psoriasis
|
|
0.100 |
GeneticVariation
|
BEFREE |
Our study showed significant associations between psoriasis and both IL12B gene SNPs, rs3212227 (odds ratio (OR) = 1.35, P = 4.94E-04) and rs6887695 (OR = 1.32, P = 2.00E-03), but no significant association between psoriasis and the IL23R SNP, rs11209026.
|
23955419 |
2013 |
rs3212227
|
|
Psoriasis
|
|
0.100 |
GeneticVariation
|
BEFREE |
One of the IL12B markers, rs3212227, showed significant association with psoriasis (OR = 1.64, P = 0.0058) while the other, rs6887695, did not (OR = 1.29, P = 0.12).
|
19705136 |
2010 |
rs3212227
|
|
Psoriasis
|
|
0.100 |
GeneticVariation
|
BEFREE |
Both IL12B markers showed highly significant association with psoriasis in the case-control (rs3212227, odds ratio (OR)=1.62, P=1.7 x 10(-15); rs6887695, OR=1.49, P=2.7 x 10(-15)) and in the family-based analysis (rs3212227, P=2.2 x 10(-3); rs6887695, P=1.7 x 10(-3)).
|
18219280 |
2008 |
rs3212227
|
|
Psoriasis
|
|
0.100 |
GeneticVariation
|
BEFREE |
Haplotypes were estimated, and genotype-conditioned analyses identified a second risk allele (rs6887695) located approximately 60 kb upstream of the IL12B coding region that exhibited association with psoriasis after adjustment for rs3212227.
|
17236132 |
2007 |