Source: ALL

Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs1800764
rs1800764
CUI: C0338656
Disease: Impaired cognition
Impaired cognition 		0.020 GeneticVariation BEFREE A trend was found for treatment with brain-penetrating ACEIs to slow cognitive decline in AD patients with the haplotype rs1800764 (CC): rs4291 (TT) (p = 0.024), and also non-significantly for independent carriers of rs1800764 or rs4291. 24577465

2014
dbSNP: rs1800764
rs1800764
CUI: C0338656
Disease: Impaired cognition
Impaired cognition 		0.020 GeneticVariation BEFREE At the level of genotypic association, we confirmed that the APOE ε4 homozygote significantly accelerated cognitive decline and found that carriers of the ACE rs1800764_C allele were more likely to show cognitive decline than noncarriers, particularly in those without college education. 24863667

2014