Source: ALL

Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs5522
rs5522
NR3C2
CUI: C0344315
Disease: Depressed mood
Depressed mood 		0.050 GeneticVariation BEFREE To investigate the hypothesis that the MR sex-dependently influences the relation between childhood maltreatment and depression, we investigated three common and functional MR haplotypes (GA, CA, and CG haplotype, based on rs5522 and rs2070951) in a population-based cohort (N = 665) and an independent clinical cohort from the Netherlands Study of Depression and Anxiety (NESDA) (N = 1639). 25686805

2015
dbSNP: rs5522
rs5522
NR3C2
CUI: C0344315
Disease: Depressed mood
Depressed mood 		0.050 GeneticVariation BEFREE There is evidence that the Val allele of the MRI180V polymorphism (rs5522) increases the risk of depression, attention and cognitive deficits. 22584804

2013
dbSNP: rs5522
rs5522
NR3C2
CUI: C0344315
Disease: Depressed mood
Depressed mood 		0.050 GeneticVariation BEFREE In an elderly cohort, one of the functional MR gene variants, MR-I180V, associated with higher feelings of depression. 21164267

2011
dbSNP: rs5522
rs5522
NR3C2
CUI: C0344315
Disease: Depressed mood
Depressed mood 		0.050 GeneticVariation BEFREE Common functional MR single nucleotide polymorphisms (SNPs; MR -2G/C and I180V) and haplotypes were tested for association with variability in the CAR in a large cohort (Netherlands Study of Depression and Anxiety, NESDA) of patients diagnosed with a lifetime major depressive disorder (MDD). 20884124

2011
dbSNP: rs5522
rs5522
NR3C2
CUI: C0344315
Disease: Depressed mood
Depressed mood 		0.050 GeneticVariation BEFREE Future studies are warranted to evaluate whether rs5522 genotype interacts with naturalistic stressors to increase the risk of depression and whether stress-induced anhedonia might moderate such risk. 20528958

2010