Source: ALL

Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs2296651
rs2296651
SLC10A1
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma 		0.070 GeneticVariation BEFREE Our results showed that rs2296651 polymorphism was associated with a decreased risk of susceptibility to HBV infection and the development of HCC. 31117968

2019
dbSNP: rs2296651
rs2296651
SLC10A1
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma 		0.070 GeneticVariation BEFREE The NTCP S267F variant of the SLC10A1 gene exhibits protective effects against HBV and HDV infection and is associated with a reduced risk of developing to advanced stages of LC and HCC. 30685591

2019
dbSNP: rs2296651
rs2296651
SLC10A1
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma 		0.070 GeneticVariation BEFREE The S267F variant on the NTCP gene is inversely associated with the chronicity of HBV infection, progression to cirrhosis and hepatocellular carcinoma in East Asian populations. 28635613

2018
dbSNP: rs2296651
rs2296651
SLC10A1
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma 		0.070 GeneticVariation BEFREE We assessed the association of S267F with HBV resistance, HBV infection clearance, and HBV-related cirrhosis and hepatocellular carcinoma (HCC). 29905807

2018
dbSNP: rs2296651
rs2296651
SLC10A1
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma 		0.070 GeneticVariation BEFREE Meta-analysis also showed that NTCP rs2296651-GA was inversely associated with HBV infection [OR(95%CI)=0.532(0.287-0.986), <i>p</i>=0.028, codominant] or HBV-related HCC [OR(95%CI)=0.701(0.564-0.872), <i>p</i>=0.001, recessive]. 29285260

2017
dbSNP: rs2296651
rs2296651
SLC10A1
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma 		0.070 GeneticVariation BEFREE The frequency of the S267F variant in CHB, cirrhosis and hepatocellular carcinoma (HCC) patients was 3.3%, 0.9%, and 3.5%, respectively. 29247233

2017
dbSNP: rs2296651
rs2296651
SLC10A1
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma 		0.070 GeneticVariation BEFREE Together with serum HBV DNA levels, S267F may help to identify patients with CHB with very low risk of HCC. 26642861

2016