Our results revealed that IL-10 rs1800872 T>G and rs1800896 A>G polymorphisms has a significantly association with the increased risk of esophageal cancer under the allele and dominant models; rs1800871 T>G, rs1800872 T>G and rs1800896 A>G under allele and dominant models could increase the risk of nasopharyngeal cancer; rs1800871T>G, rs1800872T>G and rs1800896 A>G SNPs under allele model were closely related to the susceptibility to oral cancer.
A total of 698 native Taiwanese consisting of 176 cases and 522 controls were enrolled in this hospital-based study, and three single-nucleotide polymorphism sites at promoter regions of IL10, A-1082G (rs1800896), T-819C (rs3021097), and A-592C (rs1800872) were genotyped by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) and their interaction with smoking habit for NPC risk were evaluated.