Genetic variants in microRNAs (miRNAs/miRs) play an important role in the susceptibility of various types of cancers.<b>Objective:</b> To evaluate the association of Single Nucleotide Polymorphisms (SNPs) in miR-146a (rs2910164), miR-196a2 (rs11614913), and miR-499 (rs3746444), with cervical cancer susceptibility in Indian population.<b>Methods:</b> Three hundred samples were genotyped by Polymerase chain reaction (PCR)-Restriction fragment length polymorphism (RFLP).
Because genetic variants in microRNAs (miRNAs) or their surrounding regions can alter miRNA processing, expression and final biological function, we investigated whether miRNA single-nucleotide polymorphisms (SNPs) are associated with cervical cancer (CC) susceptibility.Common miRNA SNPs (i.e. miR-146a rs2910164, miR-149 rs2292832, miR-196a2 rs11614913, miR-499 rs3746444, miR-605 rs2043556 and miR-618 rs2682818) were genotyped in the 954 patients and 1339 controls.
Similarly, rs11614913 in miR-125a was associated with CIN and cervical cancer (<i>P</i>=0.025 and 0.015, respectively), and the T allele might be the protective factor for CIN (<i>OR</i>=0.807, <i>95% CI</i>: 0.669-0.974) and cervical cancer (<i>OR</i>=0.814, <i>95% CI</i>: 0.689-0.961).