|
rs514049
|
|
Alzheimer's Disease
|
|
0.030 |
GeneticVariation
|
BEFREE |
To determine the role of A disintegrin and metalloproteinase 10 (ADAM10) in genetic susceptibility to Alzheimer's disease (AD) in a representative Chinese sample, we genotyped 362 AD patients and 370 healthy controls for the rs514049A/C and rs653765C/T polymorphisms in the ADAM10 promoter using the SNaPshot technique.
|
30555509 |
2018 |
|
rs514049
|
|
Alzheimer's Disease
|
|
0.030 |
GeneticVariation
|
BEFREE |
In contrast, the rs514049 polymorphism was not statistically associated with AD.
|
30555509 |
2018 |
|
rs514049
|
|
Alzheimer's Disease
|
|
0.030 |
GeneticVariation
|
BEFREE |
As for the ADAM10 gene, the two target SNPs (rs514049 and rs653765) were not associated with the risk of sAD either.
|
25631235 |
2015 |
|
rs514049
|
|
Alzheimer's Disease
|
|
0.030 |
GeneticVariation
|
BEFREE |
Results from this investigation suggest that the ADAM10 rs514049-rs653765 C-A promoter haplotype is associated with: (1) higher CSF sAPPα levels in cognitively normal controls compared with Alzheimer's disease (AD) patients, (2) higher postmortem brain hippocampus, but not cerebellum, ADAM10 protein levels in subjects with low plaque scores compared with those with high plaque scores, and (3) higher promoter activity for promoter-only reporter constructs compared with promoter 3' untranslated region (3'UTR) constructs in the human neuroblastoma SHSY5Y cell line, but not in HepG2 or U118 cell lines.
|
22572541 |
2012 |
|
rs653765
|
|
Alzheimer's Disease
|
|
0.030 |
GeneticVariation
|
BEFREE |
To determine the role of A disintegrin and metalloproteinase 10 (ADAM10) in genetic susceptibility to Alzheimer's disease (AD) in a representative Chinese sample, we genotyped 362 AD patients and 370 healthy controls for the rs514049A/C and rs653765C/T polymorphisms in the ADAM10 promoter using the SNaPshot technique.
|
30555509 |
2018 |
|
rs653765
|
|
Alzheimer's Disease
|
|
0.030 |
GeneticVariation
|
BEFREE |
The present study indicated that the rs653765 polymorphism might be associated with the risk and development of LOAD; in particular, the risk genotype, CC, may decrease the expression of ADAM10, influencing the plasma levels of sRAGE, and thus may be correlated with the clinical progression of AD.
|
30555509 |
2018 |
|
rs653765
|
|
Alzheimer's Disease
|
|
0.030 |
GeneticVariation
|
BEFREE |
As for the ADAM10 gene, the two target SNPs (rs514049 and rs653765) were not associated with the risk of sAD either.
|
25631235 |
2015 |
|
rs653765
|
|
Alzheimer's Disease
|
|
0.030 |
GeneticVariation
|
BEFREE |
Results from this investigation suggest that the ADAM10 rs514049-rs653765 C-A promoter haplotype is associated with: (1) higher CSF sAPPα levels in cognitively normal controls compared with Alzheimer's disease (AD) patients, (2) higher postmortem brain hippocampus, but not cerebellum, ADAM10 protein levels in subjects with low plaque scores compared with those with high plaque scores, and (3) higher promoter activity for promoter-only reporter constructs compared with promoter 3' untranslated region (3'UTR) constructs in the human neuroblastoma SHSY5Y cell line, but not in HepG2 or U118 cell lines.
|
22572541 |
2012 |
|
rs1194931775
|
|
Alzheimer's Disease
|
|
0.010 |
GeneticVariation
|
BEFREE |
Crucially, we also show that the Alzheimer's disease-associated H157Y TREM2 variant was shed more rapidly than wild type from HEK293 cells, possibly by a novel, batimastat- and ADAM10-siRNA-independent, sheddase activity.
|
28855301 |
2017 |
|
rs1336015995
|
|
Alzheimer's Disease
|
|
0.010 |
GeneticVariation
|
BEFREE |
Shedding is not altered for the R47H-mutated TREM2 protein that confers an increased risk for the development of Alzheimers disease.
|
28923481 |
2017 |
|
rs145518263
|
|
Alzheimer's Disease
|
|
0.010 |
GeneticVariation
|
BEFREE |
Here, we present evidence for genetic association of ADAM10 with Alzheimer's disease (AD) as well as two rare potentially disease-associated non-synonymous mutations, Q170H and R181G, in the ADAM10 prodomain.
|
19608551 |
2009 |
|
rs2305421
|
|
Alzheimer's Disease
|
|
0.010 |
GeneticVariation
|
BEFREE |
A common polymorphism (rs2305421) within ADAM10 has been recently associated with the risk of developing AD in Europeans.
|
21959176 |
2011 |
|
rs61751103
|
|
Alzheimer's Disease
|
|
0.010 |
GeneticVariation
|
BEFREE |
Here, we present evidence for genetic association of ADAM10 with Alzheimer's disease (AD) as well as two rare potentially disease-associated non-synonymous mutations, Q170H and R181G, in the ADAM10 prodomain.
|
19608551 |
2009 |