|
rs17070145
|
|
Alzheimer's Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
However, the impact of rs17070145 on longitudinal cognitive decline and hippocampal atrophy in CN adults at greatest risk of developing Alzheimer's disease is unknown.
|
29391469 |
2018 |
|
rs17070145
|
|
Alzheimer's Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
KIBRA single nucleotide polymorphism (rs17070145) has been linked to episodic memory performance as well as an increased risk of Alzheimer's disease and post-traumatic stress disorder (PTSD).
|
30134813 |
2018 |
|
rs17070145
|
|
Alzheimer's Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
In conclusion, our results suggest that the effect of the WWC1 rs17070145 polymorphism on memory performance and Alzheimer's disease might be due to a differential regulation of the MAPK signaling, a key pathway involved in memory and learning processes.
|
28380666 |
2017 |
|
rs17070145
|
|
Alzheimer's Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
There was a significant association among high alcohol consumption (HAC-AD group) and the genotypic and allelic frequencies of the rs17070145 polymorphism.
|
25800888 |
2015 |
|
rs17070145
|
|
Alzheimer's Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
Genetic variation at the KIBRA rs17070145 polymorphism has been linked to episodic memory, executive function, and Alzheimer's disease (AD), which are related to the structural and functional integrity of the default-mode network (DMN) and executive control network (ECN).
|
23266749 |
2013 |
|
rs17070145
|
|
Alzheimer's Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
The human KIBRA gene has been linked to human cognition through a lead intronic single-nucleotide polymorphism (SNP; rs17070145) that is associated with episodic memory performance and the risk to develop Alzheimer's disease.
|
23778582 |
2013 |
|
rs17070145
|
|
Alzheimer's Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
Recently, KIBRA (rs17070145) was reported to be associated with AD in the genetic and functional levels in Caucasian and African-American, and the association might be different across age groups.
|
24190487 |
2013 |
|
rs17070145
|
|
Alzheimer's Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
In this study, we investigated whether the KIBRA rs17070145 SNP influences AD episodic memory and the disease in a Japanese cohort.
|
20881395 |
2010 |
|
rs17070145
|
|
Alzheimer's Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
Lastly, non-carriers of the KIBRA rs17070145 T-allele had increased risk of late-onset AD in an association study of 702 neuropathologically verified expired subjects (P=0.034; OR=1.29) and in a combined analysis of 1026 additional living and expired subjects (P=0.039; OR=1.26).
|
18789830 |
2010 |
|
rs17070145
|
|
Alzheimer's Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
The first genome-wide association study of human memory identified an association between a common T/C polymorphism of the KIBRA gene (rs17070145) and episodic memory performance in normal individuals; subsequent studies have implicated the same polymorphism in Alzheimer's disease.
|
20185150 |
2010 |
|
rs17070145
|
|
Alzheimer's Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
Our Cross-sectional investigation of 312 adults aged 50-89 years free of dementia included genotyping of the KIBRA rs17070145 gene and the assessment of episodic memory to Establish a Registry for Alzheimer's Disease (CERAD).
|
18194457 |
2009 |
|
rs17070145
|
|
Alzheimer's Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
The current study reveals that KIBRA (rs17070145) T allele (CT and TT genotypes) is associated with an increased risk (OR 2.89; p=0.03) for very-late-onset (after the age of 86 years) AD.
|
17707552 |
2009 |