|
rs242557
|
|
Alzheimer's Disease
|
|
0.060 |
GeneticVariation
|
BEFREE |
The proposed sensor, carried out on microfluidic chemiluminescence (CL) assay, can sensitively discriminate rs242557 hotspot-SNP, the A/G single-nucleotide variation on human chromosome associated with Alzheimer's disease, with an absolute detection limit of 0.3 fmol.
|
28340771 |
2017 |
|
rs242557
|
|
Alzheimer's Disease
|
|
0.060 |
GeneticVariation
|
BEFREE |
A significant association of SNP rs242557 with AD risk was found in a dominant [odds ratio (OR) = 1.05, 95% confidence interval (CI) = 1.01, 1.10, P = 0.025] genetic model, and a suggestive association in an allelic (OR = 1.03, 95% CI = 1.00, 1.06, P = 0.078).
|
28415654 |
2017 |
|
rs242557
|
|
Alzheimer's Disease
|
|
0.060 |
GeneticVariation
|
BEFREE |
Published studies revealed that the microtubule-associated protein tau (MAPT) gene polymorphisms increased Alzheimer's disease (AD) risk; the associations of 4 single nucleotide polymorphisms (SNPs, rs242557G/A, rs2471738C/T, rs3785883G/A and rs1467967A/G) of the MAPT gene with AD risk, however, remain inconclusive.
|
28415654 |
2017 |
|
rs242557
|
|
Alzheimer's Disease
|
|
0.060 |
GeneticVariation
|
BEFREE |
This study demonstrated that different variants in MAPT were associated with AD (rs2471738: OR= 1.04, 95%CI = 1.00 - 1.09; H2: OR = 0.94, 95% CI = 0.91 - 0.97), PD (H2: OR = 0.76, 95% CI = 0.74 - 0.79), PSP (rs242557: OR = 1.96, 95% CI = 1.71 - 2.25; rs2471738: OR = 1.85, 95% CI = 1.
|
28402959 |
2017 |
|
rs242557
|
|
Alzheimer's Disease
|
|
0.060 |
GeneticVariation
|
BEFREE |
In both European study and our study, the SNP rs242557 showed association with AD.
|
24923570 |
2015 |
|
rs242557
|
|
Alzheimer's Disease
|
|
0.060 |
GeneticVariation
|
BEFREE |
SNCA rs356165 and the MAPT H1 specific SNP rs242557 did not associate with AD or LB pathology.
|
22291217 |
2012 |
|
rs242557
|
|
Alzheimer's Disease
|
|
0.060 |
GeneticVariation
|
BEFREE |
In a case-control study of 300 AD patients and 360 healthy controls, we examined whether the combined gene effects between HO-1 (-413, rs2071746) and tau (5' of exon 1, rs242557) polymorphisms might be responsible for susceptibility to AD.
|
18841019 |
2008 |