|
rs386747134
|
|
Alzheimer's Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
Recent studies investigating the association of Calcium homeostasis modulator 1 (CALHM1) p.P86L polymorphism (rs2986017) with Alzheimer's disease (AD) are controversial.
|
26700797 |
2016 |
|
rs386747134
|
|
Alzheimer's Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
In conclusion, our comprehensive meta-analysis indicated that P86L polymorphism is significantly associated with an increased risk for AD.
|
26944452 |
2016 |
|
rs386747134
|
|
Alzheimer's Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
These results suggest that in the presence of Aβ, P86L-CALHM1 shifts the balance between neurodegeneration and neuronal survival toward the stimulation of pro-cytotoxic pathways, thus potentially contributing to its deleterious effects in AD.
|
26416646 |
2015 |
|
rs386747134
|
|
Alzheimer's Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
Our study suggests that CALHM1 p.P86L variation may not be an AD susceptibility factor in the Han Chinese population.
|
24630757 |
2014 |
|
rs386747134
|
|
Alzheimer's Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
A genetic polymorphism (p. P86L) in CALHM1 reduces plasma membrane Ca(2+) permeability and is associated with an earlier age-at-onset of AD.
|
24069280 |
2013 |
|
rs386747134
|
|
Alzheimer's Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
Our data, however, revealed a significant association of CALHM1 P86L with elevated CSF Aβ42 and Aβ40 in the normal cohort at risk for AD.
|
21629967 |
2012 |
|
rs386747134
|
|
Alzheimer's Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
Our findings suggest that the CALHM1 P86L common variant may not influence AD risk in Japanese.
|
19655363 |
2010 |
|
rs386747134
|
|
Alzheimer's Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
A recent study identified a polymorphism (Pro86Leu) in the Calcium homeostasis modulator 1 (CALHM1) gene whose minor Leucine allele showed a higher frequency in Alzheimer's disease (AD) patients compared to controls (29% in AD and 22% in controls).
|
20164602 |
2010 |
|
rs386747134
|
|
Alzheimer's Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
Our results indicate that the CALHM1 P86L polymorphism is likely not a genetic determinant of AD but may modulate age of onset by interacting with the effect of the ε4 allele of the APOE gene.
|
20847397 |
2010 |
|
rs386747134
|
|
Alzheimer's Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
Recently, the P86L alteration in CALHM1 (calcium homeostasis modulator-1) was reported to be associated with Alzheimer's disease (AD).
|
20005921 |
2010 |
|
rs386747134
|
|
Alzheimer's Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
Importantly, we found that adjusted mean age at AD onset in P86L homozygous LOAD patients was significantly earlier that in the rest of patients (77.01 +/- 6.1 for P86L homozygous carriers versus 79.0 +/- 6.0 for the rest of patients, p=0.002).
|
20164592 |
2010 |
|
rs386747134
|
|
Alzheimer's Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
Its mutated channel P86L-CALHM1 has been associated to Alzheimer's disease (AD).
|
19944073 |
2010 |
|
rs386747134
|
|
Alzheimer's Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
Our study indicates that the CALHM1-P86L polymorphism is associated with AD in the ethnic Chinese Han.
|
20061624 |
2010 |
|
rs386747134
|
|
Alzheimer's Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
A non-synonymous polymorphism, rs2986017 (p.P86L), in the newly characterized calcium homeostasis modulator 1 (CALHM1) gene located in the Alzheimer dementia (AD) linkage region on 10q24.33, was reported to increase risk of AD, and affect calcium homeostasis and amyloid beta accumulation.
|
19191332 |
2009 |
|
rs386747134
|
|
Alzheimer's Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
Importantly, we determined that the CALHM1 P86L polymorphism (rs2986017) is significantly associated with AD in independent case-control studies of 3404 participants (allele-specific OR = 1.44, p = 2 x 10(-10)).
|
18585350 |
2008 |